Mass spectrometry is a well accepted technique for peptide sequencing and analysis of post-translational modification. In conjunction with accumulating protein and gene sequence databases, we are using state-of-the-art mass spectrometry for large-scale protein identification which is indispensable for proteomics research. We apply the following developed methods to the structural analysis of micro quantities of peptides, proteins, and their related substances.
Current Research Programs
- Development of chemical/analytical methods and software for analysis of protein primary structure by mass spectrometry
- Mass spectrometric analysis of post-translational modifications
- Development of chemical and analytical methods for proteomics
- Study on fragmentation in mass spectrometry of peptides and carbohydrates
- Development of a chemical derivatization method (4-aminobenzoic acid 2-(diethylamino)ethyl ester) for high sensitive detection of sugar chains of a glycoprotein
- Hardware development for high-sensitivity mass spectrometry