Headline News

Publication: “Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis”

Nucleic Acids Research Breakthrough article describes the biological role of subtelomeric sequences in chromosome maintenance and chromatin structure.

Research teams led by Dr. Junko Kanoh at Osaka University and by Kunihiro Ohta at the University of Tokyo (Japan), have described a study of the biological function of subtelomeric homologous (SH) sequences (and of subtelomeres more generally) through phenotypic analysis of a Schizosaccharomyces pombe (fission yeast) mutant in which all SH sequences in the genome were deleted.





A paper by Dr. Gert-Jan Bekker has been published from Journal of Chemical Theory and Computation with its cover picture of the Issue 7, 2017.

A paper”Accurate Prediction of Complex Structure and Affinity for a Flexible Protein Receptor and its Inhibitor (http://pubs.acs.org/doi/abs/10.1021/acs.jctc.6b01127, DOI: 10.1021/acs.jctc.6b01127) by Dr. Gert-Jan Bekker, who is a Specially Appointed Assistant Professor in IPR, has been published from Journal of Chemical Theory and Computation (JCTC, IF=5.301) with its cover picture of the Issue 7, 2017.



A new portal site, JBI (Japan alliance for Bioscience Information), has started to support the integrated activities of biological basic databases in Japan

Protein Data Bank Japan (PDBj), Institute for Protein Research, Osaka University has launched the JBI (Japan alliance for Bioscience Information) portal site in collaboration with National Bioscience Database Center (NBDC), JST; Database Center for Life Science (DBCLS), Joint Support-Center for Data Science Research, ROIS; and DNA Data Bank of Japan (DDBJ), National Institute of Genetics, ROIS. This portal site provides one-stop service of databases and tools which are helpful in various scenes of the life science research.

Visit the website (http://jbioinfo.jp/) for more detail.

Press Release: Calredoxin, a novel protein for promoting efficient photosynthesis


A group of researchers reports on the structure and function of a novel protein named “Calredoxin”. Calredoxin binds calcium and catalyzes in dependence of its binding, redox reactions, particularly driving the detoxification of harmful oxygen species. The researchers are exploring how this protein functions at the crossroad of calcium- and redox-dependent reactions to promote efficient oxygenic photosynthesis.

Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing.

A chromosome is composed of structurally and functionally distinct domains. However, the molecular mechanisms underlying the formation of chromatin structure and the function of subtelomeres, the telomere-adjacent regions, remain obscure. Here we report the roles of the conserved centromeric protein Shugoshin 2 (Sgo2) in defining chromatin structure and functions of the subtelomeres in the fission yeast Schizosaccharomyces pombe.