Scientific Topics

  • HOME
  • Scientific Topics
  • Publications

Publications

Manufacturing of chemically defined and xeno-free substrates for cultivation of clinical-grade human iPS cells
2015/ 4/ 6

Outline Abstract:   Osaka University and Nippi Inc., a Japanese biotech company having an expertise in ...

Protein-4.1G-Mediated Membrane Trafficking Is Essential for Correct Rod Synaptic Location in the Retina and for Normal Visual Function.
2015/ 2/ 6

Outline •Protein 4.1G is essential for the arrangement of correct retinal synapse location
•4.1G contributes to membrane-trafficking system mediated by neuronal AP3
•Retinal synaptic location is important for establishing normal visual acuity
•Normal membrane trafficking is essential for synaptic integrity maintenance

Structural basis for amyloidogenic peptide recognition by ​sorLA
2015/ 2/ 3

Outline SorLA is a neuronal sorting receptor considered to be a major risk factor for Alzheimer's disease. We have recently reported that it directs lysosomal targeting of nascent neurotoxic ​amyloid-β (​Aβ) peptides by directly binding ​Aβ. Here, we determined the crystal structure of the human ​sorLA domain responsible for ​Aβ capture, Vps10p, in an unbound state and in complex with two ligands.

Grease matrix as a versatile carrier of proteins for serial crystallography
2014/11/ 6

Outline Michihiro Sugahara, Eiichi Mizohata, Eriko Nango, Mamoru Suzuki, Tomoyuki Tanaka, Tetsuya Masuda, Rie Tanaka, Tatsuro Shimamura, Yoshiki Tanaka, Chiyo Suno, Kentaro Ihara, Dongqing Pan, Keisuke Kakinouchi, Shigeru Sugiyama, Michio Murata, Tsuyoshi Inoue, Kensuke Tono, Changyong Song, Jaehyun Park, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, So Iwata, "Grease matrix as a versatile carrier of proteins for serial crystallography", Nature Methods, 2014, doi: 10.1038/nmeth.3172.

Canonical Non-homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-specific Phosphorylation of XRCC4.
2014/ 9/ 1

Outline Masahiro Terasawa, Akira Shinohara, Miki Shinohara

Cold Denaturation of Alpha-Synuclein Amyloid Fibrils.
2014/ 6/30

Outline Ikenoue T, Lee Y H, Kardos J, Saiki M, Yagi H, Kawata Y, Goto Y.,
Angew Chem Int Ed Engl. 2014 Jun 11. [doi: 10.1002/anie.201403815.]

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
2014/ 4/30

Outline Taro Chaya, Yoshihiro Omori, Ryusuke Kuwahara & Takahisa Furukawa,
EMBO J. 2014 Jun 2;33(11):1227-42. [doi: 10.1002/embj.201488175.]

Heat of supersaturation-limited amyloid burst directly monitored by isothermal titration calorimetry.
2014/ 4/22

Outline Tatsuya Ikenouea,d, Young-Ho Leea,d, József Kardosb, Hisashi Yagia, Takahisa Ikegamia, Hironobu Naikic and Yuji Goto. Proc Natl Acad Sci U S A. 2014

Profile conditional random fields for modeling protein families with structural information.
2009/ 6/ 8

Outline Kinjo AR BIOPHYSICS, 5:37-44(2009)   http://www.jstage.jst.go.jp/article/biophysics/5/0/5_37/_a...

Structure of the connexin 26 gap junction channel at 3.5 Å resolution
2009/ 4/ 9

Outline Shoji Maeda, So Nakagawa, Michihiro Suga, Eiki Yamashita, Atsunori Oshima, Yoshinori Fujiyoshi &am...

Intra- and Intermolecular Interaction Inducing Pyramidalization on both sides of a Proline Di-peptide during Isomerization: an ab Initio QM/MM Molecular Dynamics Simulation Study in explicit water.
2009/ 3/27

Outline Y. Yonezawa, K. Nakata, K. Sakakura, T. Takada, H. Nakamura   J. Ame. Chem. Soc. (2009) 131 (12...

Comprehensive structural classification of ligand binding motifs in proteins.
2009/ 3/27

Outline A. R. Kinjo, H. Nakamura   Structure (2009) 17 (2), 234-246   http://www.cell.com/structur...

Destruction of Amyloid Fibrils of beta2-Microglobulin Fragment by Laser Beam Irradiation
2009/ 1/20

Outline Ozawa D, Yagi H, Ban T, Kameda A, Kawakami T, Naiki H, Goto Y J. Biol. Chem. (2009) 284(2), 1009-101...

The Structure of Rat Liver Vault at 3.5 Angstrom Resolution
2009/ 1/16

Outline Hideaki Tanaka, Koji Kato, Eiki Yamashita Tomoyuki Sumizawa, Yong Zhou, Min Yao, Kenji Iwasaki, Masa...

Structural Evolution of Reoviridae Revealed by Oryzavirus in Acquiring the Second Capsid Shell.
2008/11/25

Outline Miyazaki N, Uehara-Ichiki T, Xing L, Bergman L, Higashiura A, Nakagawa A, Omura T, Cheng RH J. Virol...
1 | 2

↑ Page Top