Laboratories & Administration Office
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- Laboratories & Administration Office
- Division of Integrated Protein Functions
Laboratory of Homeostatic Integration
member
| 准教授 | Nobuaki OKUMURA |
|---|
連絡先
| Tel | 81-6-6879-4312 |
|---|---|
| Fax | 81-6-6879-4312 |
研究概要
Living organisms have to adopt environmental conditions that are fluctuating hour by hour and day by day. A key environmental factor for an organism is the day/night cycle. In mammals, the hypothalamus produces 24h rhythms of physiology and behavior and organizes homeostatic regulation of blood glucose, energy expenditure, etc. through the autonomic and the endocrine systems. We are studying how the central circadian clock works and how the hypothalamus organizes the homeostatic regulation.
<Fig.1>
Homeostatic regulation by the hypothalamus. Homeostasis of internal body
conditions such as blood glucose, body temperature, and energy
expenditure are regulated by the autonomic nervous system and the
endocrine systems under the control of the hypothalamus.
<Fig.2>
Localization of carnosinase CN2 in the hypothalamus.We have found that a
dipeptide L-carnosine reduces blood glucose and sympathetic nerve activity.
More recently, a carnosine-degrading enzyme, CN2, was cloned and was
found to be localized in histaminergic neurons of the hypothalamic
tuberomammillary nucleus.
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