Laboratories & Administration Office
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- Laboratories & Administration Office
- Division of Protein Chemistry
Laboratory of Extracellular Matrix Biochemistry
member
| Director | Kiyotoshi SEKIGUCHI |
|---|---|
| 助教 | Masashi YAMADA Sugiko FUTAKI |
| Technical Assistant | Naoko NORIOKA |
連絡先
| Tel | 81-6-6879-8617 |
|---|---|
| Fax | 81-6-6879-8619 |
研究概要
The goal of our laboratory is to understand the molecular basis of tissue architecture and cellular functions in multi-cellular organisms based on the cell-extracellular matrix interaction. Extracellular matrix is not a mere scaffold between cells but rather an information-rich supra-molecular structure that provide cells with signals that regulate cell growth, differentiation, and apoptosis. Cells read the barcode-like signals written in the matrix with a variety of cell surface receptors and determine whether they should grow or differentiate. Currently, we are focusing our efforts on the following research projects:
<Fig.1>
Regulation of cell growth, differentiation, and survival by extracellular matrix.
Cells have their own customized extarcellular matrix.
<Fig.2>
QBRICK family proteins characterized by 12 tandem CSPG repeats
are expressed at the basement membrane of developing hair follicles.
Defects in these proteins cause Fraser syndrome-like phenotypes.
Contact:
