Laboratories & Administration Office
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- Laboratories & Administration Office
- Research Center for Structural and Functional Proteomics
Laboratory of Protein Synthesis and Expression
member
| Director | Junichi TAKAGI |
|---|---|
| 准教授 | Kenji IWASAKI |
| 助教 | Terukazu NOGI |
| Technical Assistant | Keiko KAWAKAMII |
連絡先
| Tel | 81-6-6879-8607 |
|---|---|
| Fax | 81-6-6879-8609 |
研究概要
Cellular response to the extracellular environment depends on the "sensing" the extracellular cues by use of the receptor-ligand system. Binding of ligands to the extracellular domain of the receptors transduce signals into cells that initiates various cellular events, ultimately changing the cell fate. Most of the "signal transduction researches" deal with cytoplasmic events such as phosphorylation/dephosphorylation of signaling molecules and subsequent recruitment of adapter molecules, but mechanism for the "signal transmission across the membrane", the very first step in the signaling pathway is poorly understood. Our study focuses on questions such as how receptors recognize their specific ligands, how this recognition leads to structural change in the receptor complex, and how the information cross the plasma membrane without transporting chemical entity. Using structural as well as chemical approach, we would tackle on this difficult problem to obtain insights into the mechanism of transmembrane signaling.
<Fig.1>
Structure of receptor-binding fragment of reelin determined by X-ray
crystallography(2.0 Å resolution). Two Zn2+-binding sites (insets) were identified
on the molecular surface.
<Fig.2>
Electron microscopy on an infectious tubule containing rice dwarf virus. A slice
image (left) and a segmented rendering (right) from the 3-D tomograms are shown.
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