１．ペプチド・蛋白質の合成法に関する研究
Toru Kawakami, Saburo Aimoto, The Use of a Cysteinyl Prolyl Ester (CPE) Autoactivating Unit in Peptide Ligation Reactions, Tetrahedron, 65, 3871-3877 (2009)
T. Hara, A. Tainosho, K. Nakamura, T. Sato, T. Kawakami, and S. Aimoto, Peptide purification by affinity chromatography based on α-ketoacyl group chemistry, J. Peptide Sci., 15, 369-376 (2009)
Y. Inaba, T. Kawakami, S. Aimoto, T. Ikegami, T. Takeuchi, T. Nakazawa, S.Yano, and Y. Mikata, Preparation and conformational analysis of C-glycosyl beta(2)- and beta/beta(2)-peptides, Carbohydrate Res., 344(5), 613-26 (2009)
T. Kawakami, S. Aimoto, Sequential peptide ligation by using a controlled cysteinyl prolyl ester (CPE) autoactivating unit, Tetrahedron Lett., 48, 1903-1905 (2007)
K. Nakamura, H. Mori, T. Kawakami, H. Hojo, Y.Nakahara, S. Aimoto, Peptide Thioester Synthesis via an Auxiliary-Mediated N-S Acyl Shift Reaction in Solution, Int. J. Peptide Res. Therapeutics, 13, 191-202 (2007)
T. Kawakami, S. Aimoto, Peptide Ligation Using the Cysteinyl Prolyl Ester (CPE) Activating Unit at the Carboxy Terminus, Chem. Lett., 36, 76-77 (2007)
K. Nakamura, M. Sumida, T. Kawakami, T. Vorherr, S. Aimoto, Generation of an S-Peptide via an N-S Acyl Shift Reaction in TFA Solution, Bull Chem Soc. Jpn., 79, 1773-1780 (2006)
T. Kawakami, M. Sumida, K. Nakamura, T. Vorherr, S. Aimoto, Peptide Thioester Preparation Based on an N-S Acyl Shift Reaction Mediated by a Thiol Ligation Auxiliary, Tetrahedron Lett., 46, 8805-8807 (2005)
T. Kawakami, M. Tsuchiya, K. Nakamura, S. Aimoto, Sequential Peptide Chemical Ligation by the Thioester Method and Extended Chemical Ligation, Tetrahedron Lett., 46, 5533-5536 (2005)
T. Sato, Y. Saito, S. Aimoto, Synthesis of the C-terminal Region of Opioid Receptor Like 1 in an SDS Micelle by the Native Chemical Ligation: Effect of Thiol Additive and SDS Concentration on Ligation Efficiency, J. Peptide Sci. 11: 410-416 (2005)
Takeshi Sato and Saburo Aimoto, Use of thiosulfonate for the protection of thiol groups in peptide ligation by the thioester method. Tetrahedron Lett., 44, 8085-8087 (2003)
Toru Kawakami and Saburo Aimoto, A photoremovable ligation auxiliary for use in polypeptide synthesis. Tetrahedron Lett., 44, 6059-6061 (2003)
Koki Hasegawa, Yin Lin Sha, Jeong Kyu Bang, Toru Kawakami, Kenichi Akaji & Saburo Aimoto, Preparation of phosphopeptide thioesters by Fmoc- and Fmoc(2-F)-solid phase synthesis. Lett. Pept. Sci., 8 (3-5): 277-284 2001
Kenta Teruya, Toru Kawakami, Kenichi Akaji, and Saburo Aimoto, Total synthesis of [L40I, C90A, C109A]-human T-cell leukemia virus-type 1 protease, Tetrahedron Lett., 43, (8), 1487-1490 (2002)
Takeshi Sato, Toru Kawakami, Kenichi Akaji, Hiroki Konishi, Koji Mochizuki, Toshimichi Fujiwara, Hideo Akutsu, and Saburo Aimoto, Synthesis of a membrane protein with two transmembrane regions, J. Pept. Sci., 8, 172-180 (2002)
T. Kawakami, K. Hasegawa, K. Teruya, K. Akaji, M. Horiuchi, F. Inagaki, Y. Kurihara, S. Uesugi, and S. Aimoto, Polypeptide Synthesis Using an Expressed Peptide as a Building Block for the Condensation with a Peptide Thioester: Application to Synthesis of Phosphorylated p21Max Protein(1-101).J. Peptide Science, 7, 474-487 (2001)
Toru Kawakami, Kenichi Akaji, and Saburo Aimoto, Peptide Bond Formation Mediated by 4,5-Dimethoxy-2-mercaptobenzylamine after Periodate Oxidation of the N-Terminal Serine Residue, Org. Lett., 3 (9), 1403-1405 (2001).
T. Kawakami, K. Hasegawa, K. Teruya, K. Akaji, M. Horiuchi, F. Inagaki, Y. Kurihara, S. Uesugi, and S. Aimoto, Polypeptide synthesis using an expressed peptide as a building block via the thioester method. Tetrahedron Lett., 41, 2625-2628 (2000).
Toru Kawakami, Koki Hasegawa, and Saburo Aimoto, Synthesis of a Phosphorylated Polypeptide by a Thioester Method. Bull. Chem. Soc. Jpn., 73, 197-203 (2000)
Saburo Aimoto, Polypeptide synthesis by the thioester method, Biopolymers (Peptide science), 51, 247-265 (1999)
Mamoru Mizuno, Katsuji Haneda, Reiko Iguchi, Ikuyo Muramoto, Toru Kawakami, Saburo Aimoto, Kenji Yamamoto, and Toshiyuki Inazu, Synthesis of a Glycopeptide Containing Oligosaccharides: Chemoenzymatic Synthesis of Eel Calcitonin Analogues Having Natural N-Linked Oligosaccharides. J. American Chemical Society, 121 (2), 284-290 (1999)
Xiangqun Li, Toru Kawakami, and Saburo Aimoto, Direct preparation of peptide thioesters using an Fmoc solid-phase method. Tetrahedron Lett., 39, 8669-8672 (1998).
Toru Kawakami, Shoko Yoshimura, and Saburo Aimoto, Synthesis of Reaper, a Cysteine-Containing Polypeptide, Using a Peptide Thioester in the Presence of Silver Chloride as an Activator. Tetrahedron Lett., 39, (43) 7901-7904 (1998).
Katsuji Haneda, Toshiyuki Inazu, Mamoru Mizuno, Reiko Iguchi, Kenji Yamamoto, Hidehiko Kumagai, Saburo Aimoto, Hiroaki Suzuki and Toshiharu Noda, Chemo-enzymatic synthesis of calcitonin derivatives containing N-linked origosaccharides. Bioorganic & Medicinal Chemistry Letters 8 (1998) 1303-1306
Mamoru Mizuno, Ikuyo Muramoto, Toru Kawakami, Makoto Seike, Saburo Aimoto, Katsuji Haneda, and Toshiyuki Inazu, A Synthesis of a Glycopeptide Analogue of Eel Calcitonin. Tetrahedron Letters, 39, No. 1/2, 55-58 (1998)
Toru Kawakami and Saburo Aimoto, Condensation of Cys(Acm)-Containing Peptide Segments with Silver Chloride as an Activator of Peptide Thioesters. Chemistry Letters, 1157-1158 (1997)
Toru Kawakami, Shuji Kogure, and Saburo Aimoto, Synthesis of Cysteine-Containing Polypeptide Using a Peptide Thioester Containing a Cys(Acm) Residue. Bull. Chem. Soc. Jpn., 69, 3331-3338 (1996)
Hisakazu Mihara, Shuko Maeda, Ryo Kurosaki, Satoko Ueno, Seiji Sakamoto, Takuro Niidome, Hironobu Hojo, Saburo Aimoto, and Haruhiko Aoyagi, Peptide Synthesis Mediated by Thiolsubtilisin Using Peptide Thioester as Building Block. Chemistry Letters, 5, 397-398 (1995)
H. Hojo, S. Yoshimura, M. Go, and S. Aimoto, Preparation of S-Protected Cysteine-Containing Peptide Thioester and Its Use for the Synthesis of the Barnase-Like Domain in DNA-Directed RNA Polymerase II of Saccharomyces cerevisiae. Bull. Chem. Soc. Jpn., 68, 330-336 (1995)
H. Hojo and S. Aimoto, Synthesis of Barnase Site-Specifically Labelled with Two 13C Atoms Using Partially Protected Peptide Thioester Building Blocks. Bull. Chem. Soc. Jpn., 66, 3004-3008 (1993).
H. Hojo, Y. Kwon, Y. Kakuta, S. Tsuda, I. Tanaka, K. Hikichi, and S. Aimoto, Development of a Linker with an Enhanced Stability for the Preparation of Peptide Thioesters and Its Application to the Synthesis of Stable-Isotope-Labelled HU-Type DNA-Binding Protein. Bull. Chem. Soc. Jpn., 66, 2700-2706(1993).
Y. Kwon, R. Zhang, M. P. Bemquerer, M. Tominaga, H. Hojo, and S. Aimoto, Preparation of Partially Protected Peptide Thioester Containing a Cysteine Residue and Their Segment Condensation. Chemistry Letters, 881-884 (1993)
H. Hojo and S. Aimoto, Protein Synthesis Using S-Alkyl Thioester of a Partially Protected Peptide Segments. Synthesis of DNA-Binding Protein of Bacillus stearothermophilus. Bull. Chem. Soc. Jpn., 65, 3055-3063 (1992).
H. Hojo and S. Aimoto, Polypeptide Synthesis Using the S-Alkyl Thioester of a Partially Protected Peptide Segment. Synthesis of the DNA-Binding Domain of c-Myb Protein(142-193)-NH2. Bull. Chem. Soc. Jpn., 64, 111-117 (1991).
S. Aimoto, S. Yoshimura, N. Mizoguchi and H. Hojo, Development of a Facile Method for Polypeptide Synthesis. Synthesis of Bovine Pancreatic Trypsin Inhibitor (BPTI). Bull. Chem. Soc. Jpn., 62, 524-531 (1989).
S. Aimoto, The Synthesis of a Heavy Atom Derivative of Gramicidin S (GS), [D-Phe(4-Br)4,4']-GS, by a Novel Method. Bull. Chem. Soc. Jpn.,61, 2220-2222 (1988).
２．機能性ペプチドのデザイン・合成に関する研究
無脊椎動物の神経ペプチドに関する研究
M. Ohtani, H. Minakata, S. Aimoto,Potent antagonistic action of synthetic analogues of APGWGNamide, an antagonist of molluscan neuropeptide APGWamide, Peptides. 23, 843-52 (2002).
M. Ohtani, S. Aimoto, and Y. Muneoka, Development of an antagonist of molluscan neuropeptide APGWamide with a peptide library. Peptides, 21, 1193-1201 (2000).
M. Ohtani, Y. Muneoka, N. Kanemoto, K. Ogino, Y. Masui and S. Aimoto, Structure and Action of MIP (Mytilus Inhibitory Peptide)-Related Tetrapeptides Synthesized with a Multiple Synthesizer. Acta Biologica Hungaria , 46 , 445-448 (1995)
M. Ohtani, Y. Muneoka, N. Kanemoto, K. Ogino, Y. Masui and S. Aimoto, Structure and Action of MIP (Mytilus Inhibitory Peptide)-Related Tetrapeptides Synthesized with a Multiple Synthesizer. Acta Biologica Hungaria , 46 (2-4), 445-448 (1995)
甲殻類の脱皮抑制ホルモンに関する研究
H. Sonobe, T. Nishimura, M. Sonobe, T. Nakatsuji, R. Yanagihara, T. Kawakami, and S. Aimoto, The Molt-Inhibiting Hormone in the American Crayfish Procambarus clarkii: Its Chemical Synthesis and Biological Activity. Gen Comp Endocrinol., 121, 196-204 (2001)
MT. Nakatsuji, H. Keino, K. Tamura, S. Yoshimura, T. Kawakami, S. Aimoto, and H. Sonobe, Changes in the amounts of the molt-inhibiting hormone in the sinus glands during the molt cycle of the American crayfish, Procambarus clarkii. Zool. Sci. 17, 1129-1136 (2000)
Toru Kawakami, Chikako Toda, Kenichi Akaji, Takayuki Nishimura, Teruaki Nakatsuji, Kazuki Ueno, Maki Sonobe, Haruyuki Sonobe, and Saburo Aimoto, Synthesis of a Molt-Inhibiting Hormone of the American Crayfish, Procambarus clarkii, and Determination of the Location of Its Disulfide Linkages. J. Biochem. Vol. 128, pp. 455-461 (2000)
ヒトT細胞白血病ウイルス(HTLV)由来プロテアーゼに対する阻害剤の合成に関する研究
J. K. Bang, K. Teruya, S. Aimoto, H. Konno, K. Nosaka, T. Tatsumi, K. Akaji, Studies on substrate specificity at PR/p3 cleavage site of HTLV-1 protease, Int. J. Peptide Res. Therapeutics, 13, 173-179 (2007)
H. Naka, K. Teruya, J. K. Bang, S. Aimoto, T. Tatsumi, H. Konno, K. Nosaka, K. Akaji, Evaluations of Substrate Specificity and Inhibition at PR/p3 Cleavage Site of HTLV-1 Protease, Bioorg. Med. Chem. Lett., 16, 3761-3764,(2006)
J. K. Bang, H. Naka, K. Teruya, S. Aimoto, H. Konno, K. Nosaka, T. Tatsumi, K. Akaji, Solid-Phase Syntheses of Olefin-Containing Inhibitors for HTLV-1 Protease Using the Horner-Emmons Reaction, J. Org. Chem., 70, 10596-10599 (2005)
Jeong Kyu Bang, Koki Hasegawa, Toru, Kawakami, Saburo Aimoto, Kenichi Akaji Synthesis of an olefin-containing cyclic peptide using the solid-phase Honer-Emmons reaction, Tetrahedron Lett., 45, 99-102 (2004)
K. Akaji, K. Teruya, S. Aimoto, Solid-phase synthesis of HTLV-1 protease inhibitors containing hydroxyethylamine dipeptide isostere. J. Org. Chem., 68, 4755-4763 (2003)
Kenta Teruya, Toru Kawakami, Kenichi Akaji, and Saburo Aimoto, Total synthesis of [L40I, C90A, C109A]-human T-cell leukemia virus-type 1 protease, Tetrahedron Lett., 43, (8), 1487-1490 (2002)
３．膜蛋白質の構造解析に関する研究
T. Sato, T.-C.Tang, G. Reubins, J.Z. Fei, T. Fujimoto, P. Kienlen-Campard, S. N. Constantinescu, J.-N. Octave, S. Aimoto and S. O. Smith, Structure of the transmembrane dimer of the amyloid precursor protein: Implications for proteolysis by g-secretase, Proc. Natl Acad. Sci. USA, 106, 1421-1426 (2009)
M. Tanaka, T. Tanaka, S. Ohta, T. Kawakami, H. Konno, K. Akaji, S. Aimoto, and H. Saito, Evaluation of Lipid-Binding Properties of the N-Terminal Helical Segments in Human Apolipoprotein A-I Using Fragment Peptides, J. Peptide Sci., 15, 36-42 (2009)
S. Ujihara, T. Oishi, K. Torikai, K. Konoki, N. Matsumori, M. Murata and S. Aimoto, Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by surface plasmon resonance and saturation transfer difference NMR, Bioorg. Med. Chem. Lett., 18, 6115-8 (2008)
K. Torikai, T. Oishi, S. Ujihara, N. Matsumori, K. Konoki, M. Murata, and S. Aimoto, Design and Synthesis of Ladder-shaped Tetracyclic, Heptacyclic, and Decacyclic Ethers and Evaluation of the Interaction with Transmembrane Proteins, J. Am. Chem. Soc. 130, 10217-26 (2008)
N. Morsy, K. Konoki, T. Houdai, N. Matsumori, T. Oishi, M. Murata, and S. Aimoto, Roles of integral protein in membrane permeabilization by amphidinols, Biochim Biophys Acta. 1778, 1453-1459 (2008)
P. Kienlen-Campard, B. Tasiaux, J. Van Hees, M. Li, S. Huysseune, T. Sato, J. Z. Fei, S. Aimoto, P. J. Courtoy, S. O. Smith, S. N. Constantinescu, J. N. Octave, Amyloidogenic processing but not aicd production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs, J. Biol. Chem. 283, 7733-44 (2008)
T. Sato, P. Kienlen-Campard, M. Ahmed, W. Liu, H. Li, J. I. Elliott, S. Aimoto, S. N. Constantinescu, J. N. Octave, S. O. Smith, Inhibitors of amyloid toxicity based on β-sheet packing of Aβ40 and Aβ42, Biochemistry, 45, 5503-16 (2006)
M. Mori, T. Oishi, S. Matsuoka, S. Ujihara, N. Matsumori, M. Murata, M. Satake, Y. Oshima, N. Matsushita, S. Aimoto, Ladder-shaped polyether compound, desulfated yessotoxin, interacts with membrane-integral a-helix peptides, Bioorg. Med. Chem., 13, 5099-5103 (2005)
W. Liu, E. Crocker , W. Zhang, J. I. Elliott, B. Luy, H. Li, S. Aimoto, S. O. Smith, Structural Role of Glycine in Amyloid Fibrils Formed from Transmembrane α-Helices, Biochemistry, 44, 3591-3597 (2005)
S.O. Smith, C. Smith, S. Shekar, O. Peersen, M. Ziliox, S. Aimoto, Transmembrane interactions in the activation of the Neu receptor tyrosine kinase. Biochemistry. 41, 9321-32(2002).
S.O. Smith, M. Eilers, D. Song, E. Crocker, W. Ying, M. Groesbeek, G. Metz, M. Ziliox, S. Aimoto, Implications of threonine hydrogen bonding in the glycophorin A transmembrane helix dimer. Biophys. J., 82, 2476-86 (2002)
S.O. Smith, T. Kawakami, W. Liu, M. Ziliox, S. Aimoto, Helical Structure of Phopholamban in Membrane Bilayers. Journal of Molecular Biology 313(5): 1139-1148 (2001)
Steven O. Smith, David Song, Srinivasan Shekar, Michel Groesbeek, Martine Ziliox, and Saburo Aimoto, Structure of the transmembrane Dimer Interface of Glycophorin A in Membrane Bilayers. Biochemistry, 40, 6553-6558 (2001)
I.T. Arkin, P.D. Adams, A.T. Brunger, S. Aimoto, D.M. Engelman, S.O. Smith, Structure of the Transmembrane Cysteine Residues in Phospholamban. Journal of Membrane Biology, 115, 199-206 (1997)
Isaiah T. Arkin, Kevin R. MacKenzie, Lillian Fisher, Saburo Aimoto, Donald M. Engelman and Steven O. Smith, Mapping the Lipid-Exposed Surfaces of Membrane Proteins. Nature Structural Biology 3, No.3 240-243 (1996)
Ludlam-CF; Arkin-IT; Liu-XM; Rothman-MS; Rath-P; Aimoto-S; Smith-SO; Engelman-DM; Rothschild-KJ, Fourier transform infrared spectroscopy and site-directed isotope labeling as a probe of local secondary structure in the transmembrane domain of phospholamban. Biophysical Journal, 70, 1728-36 (1996)
Olve B. Peersen, Michel Groesbeek, Saburo Aimoto, and Steven O. Smith, Analysis of Rotational Resonance Magnitization Exchange Curves from Crystalline Peptides. J. Am. Chem. Soc., 117, 7228-7237(1995)
I.T. Arkin, M. Rothman, C.F.C. Ludlam, S. Aimoto, D.M. Engelman, K.J. Rothschild and S.O.Smith, Structural Model of the Phospholamban Ion Channel Complex in Phospholipid Membranes. J. Mol. Biol., 248,(4). 824-834 (1995)
４．合成ペプチド・蛋白質を用いた構造解析・構造形成に関する研究
T. Takai T. Takaya, M. Nakano, H. Akutsu, A. Nakagawa, S. Aimoto, K. Nagai, T. Ikegami,Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor, J. Pept. Sci.,. 12, 443-454 (2006)
Hanaoka S, Nagadoi A, Yoshimura S, Aimoto S, Li B, de Lange T, Nishimura Y. NMR Structure of the hRap1 Myb Motif Reveals a Canonical Three-helix Bundle Lacking the Positive Surface Charge Typical of Myb DNA-Binding Domains. J Mol Biol. 2001 Sep 7;312(1):167-75.
Andreas Detken, Edme H. Hardy, Matthias Ernst, Masatsune Kainosho, Toru Kawakami, Saburo Aimoto, Beat H. Meier. Methods for sequential resonance assignment in solid, uniformly 13C, 15N labelled peptides: quantification and application to antamanide. J. Biomolecular NMR, 20, 203-221 (2001)
Takahashi Ki, Noguti T, Hojo H, Yamauchi K, Kinoshita M, Aimoto S, Ohkubo T, Go M, A mini-protein designed by removing a module from barnase: molecular modeling and NMR measurements of the conformation. Protein Eng 1999 Aug;12(8):673-80
Tsuchiya S, Ogura K, Hatanaka H, Nagata K, Terasawa H, Mandiyan V, Schlessinger J, Aimoto S, Ohta H, Inagaki F, Solution structure of the SH2 domain of Grb2/Ash complexed with EGF receptor-derived phosphotyrosine-containing peptide. J Biochem (Tokyo) 1999 Jun 1;125(6):1151-1159
Daizo Hamada, Yutaka Kuroda, Mikio kataoka, Saburo Aimoto, Tetsuro Yoshimura and Yuji Goto, Role of Heme Axial Ligands in the Conformational Stability of the Native and Molten Globule States of Horse Cytochrome C. J. Mol. Biol., 256, 172-186 (1996)
L.Chothia, S. Aimoto, T. Johnson, and M. Suzuki, A-physico-Chemical Study of the DNA-binding Domain of GATA 1. Proceeding of the Japan Academy, Series B, 314-318(1995)
Jurgen M. Schmidt, Richard R. Ernst, Saburo Aimoto and Masatsune Kainosho, Detemination of Heteronuclear Three-Bond J-Coupling Constants in Peptides by a Simple Heteronuclear Relayed E.COSY Experiment. Journal of Biomolecular NMR, 5,95-105 (1995)
Kazuhiro Ogata, Souichi Morikawa, Haruki Nakamura, Hironobu Hojo, Shoko Yoshimura, Ruoheng Zhang, Saburo Aimoto, Yuko Ametani, Zenzo Hirata, Akinori Sarai, Shunsuke Ishii and Yoshifumi Nishimura, Comparison of the Free and DNA-Complexed Forms of the DNA-Binding Domain from c-Myb. Nature Structural Biology, 2, 309-320(1995)
Yoshimitsu Kakuta, Hironobu Hojo, Saburo Aimoto, Isao Tanaka, and Kunio Kikuchi, 13C-NMR Relaxation Study on Mobility of the DNA-Binding Arm of HU. J. Biochemistry, 116, 1153-1155(1994)
M. Suzuki, D. Neuhaus, M. gerstein, and S. Aimoto, Solution Structure of the DNA Binding Octapeptide Repeat of the K10 Gene Product. Protein Eng., 7, (4), 461-470(1994)
S. Ohki, U. Iwamoto, S. Aimoto, M. Yazawa, and K. Hikichi, Mg2+ Inhibits Formation of 4Ca2+-Calmodulin-Enzyme Complex at Lower Ca2+ Concentration. J. Biol. Chem., 268, 12388-12392(1993).
Y. Hagihara, S. Aimoto, A. L. Fink and Y. Goto, Guanidine Hydrochloride-Induced Folding of Protein. J. Mol. Biol., 231, 180-184(1993).
Y. Hagihara, M. Kataoka, S. Aimoto, and Y. Goto, Charge Repulsion in the Conformational Stability of Melittin. Biochemistry, 31, 11908-11914(1992).
K. Ramalingam, S. Aimoto and J. Bello, Conformational Studies of Anionic Melittin Analogues. Effect of Peptide Concentration, pH, Ionic Strength, and Temperature. Models for Protein Folding and Halophilic Proteins. Biopolymers, 32, 981-992 (1992)
S. Tsuda, S. Aimoto, and K. Hikichi, 1H-NMR Study of Ca++- and Mg++-Dependent Interaction between Troponin C and Troponin I Inhibitory Peptide(96-116). J. Biochem. (Tokyo), 112, 665-670(1992).
K. Ogata, H. Hojo, S. Aimoto, T. Nakai, H. Nakamura, A. Sarai, S. Ishii and Y. Nishimura, Solution Structure of a DNA-Binding Unit of Myb: A Helix-Turn-Helix-Related Motif with Conserved Tryptophans Forming a Hydrophobic Core. Proc. Natl. Acad. Sci. USA, 89, 6428-6432 (1992)
C. Kanei-Ishii, E. M. MacMillan, T. Nomura, A. Sarai, R. G. Ramsay, S. Aimoto, S. Ishii, and T. J. Gonda, Transactivation and Transformation by Myb Are Negatively Regulated by a Leucine-Zipper Structure. Proc. Natl. Acad. Sci. USA, 89, 3088-3092 (1992)
K. Ramalingam, S. Aimoto, J. Bello, Conformational Stdues of Anionic Melittin Analogs-Effect of Peptide Concentration, Ph, Ionic-Strength, and Tempeerature-Models for Protein Folding and Halophilic Proteins Biopolymers 32(8): 981-992 (1992)
K. Ramalingam, J. Bello and S. Aimoto, Conformational Change in Melittin upon Complexation with an Anionic Melittin Analog. FEBS Lett., 295, 200-202(1991).
Y. Goto, N. Okamura and S. Aimoto, ATP-Induced Conformational Transition of Denatured Proteins. J. Biochem., 109, 746-750(1991).
Y. Ohta, H. Hojo, S. Aimoto, T. Kobayashi, X. Zhu, F. Jordan and M. Inouye, Pro-Peptide as an Intermolecular Chaperone: Renaturation of Denatured Subtilisin-E withS. a Synthetic Pro-Peptide. Mol. Microbiol., 5, 1507-1510 (1991)
Y. Goto and S. Aimoto, Anion- and pH-dependent Conformational Transition of an Amphiphilic Polypeptide. J. Mol. Biol., 218, 387-396(1991).
