H3-rules 2007: Identification of CDR-H3 structures in antibodies


Input an amino acid sequence of CDR-H3 from conserved Cys(-2) to Trp(n+1), which is coresponding to the Kabat numbering from 92 to 103, and the residues at the position of L36, L46 and L49.
Note: it is important for the basic residues to be located at the position of L46 or L49, and for Tyr at the position of L36.


CDR-H3 (Example: CASKYYNGDFDYW)


L36 (Y in general)


L46 (L in general)


L49 (Y in general)


Methods

Reference
  • Kuroda, D., Shirai, H., Kobori, M., Nakamura, H. (2008) PROTEINS. 73(3):608-620.
  • Shirai, H., Kidera, A., Nakamura, H. (1999) FEBS Lett. 455, 188-197.
  • Shirai, H., Kidera, A., Nakamura, H. (1996) FEBS Lett. 399, 1-8.

    Last updated 23-May-2011

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