大阪大学 蛋白質研究所 機能・発現プロテオミクス研究室
Institute for Protein Research, Osaka University
Laboratory of Protein Profiling and Functional Proteomics



  1. Takada R, Satomi Y, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T,and Takada S. Mono-unsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion. Dev. Cell, 11, 791-801, 2006.

  2. Ichimura, Y., Kirisako, T., Takao T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Ishii, T., Ohsumi, M., Noda, T., and Ohsumi, Y. Ubiquitination-like system mediates novel protein-lipidation. Nature 408, 488-492, 2000.

  3. Shimizu, T., Hozumi, K., Horiike, S., Nunomura, K., Ikegami, S., Takao T., and Shimonishi, Y.: A Covalently Cross-Linked Histone Heterodimer in Starfish. Nature 380, 32, 1996.

  4. Kokame, K., Fukada, Y., Yoshizawa, T., Takao T., and Shimonishi, Y.: Lipid Modification at the N Terminus of Photoreceptor G-Protein α-Subunit. Nature 359, 749-751, 1992.

  5. Takao T., Gonzalez, J., Yoshidome, K., Sato, K., Asada, T., Kammei, Y., and Shimonishi, Y.: Automatic Precursor-Ion Switching in a Four-Sector Tandem Mass Spectrometer and Its Application to Acquisition of the MS/MS Product Ions Derived from a Partially 18O-Labeled Peptide for Their Facile Assignments. Anal. Chem. 65, 2394-2399, 1993.

  6. Fukada, Y., Takao T., Ohguro, H., Yoshizawa, T., Akino, T., and Shimonishi, Y.: Farnesylated γ-Subunit of Photoreceptor G Protein Indispensable for GTP-Binding. Nature 346, 658-660, 1990.


  1. Wang Y, Nakajima E, Okamura Y , Wang D , Okumura N, Takao T. Metastable decomposition at the peptide C‐terminus: Possible use in protein identification . Rapid Communications in Mass Spectrometry, 07 February 2020 .

  2. Wang Q, Shimizu K, Maehata K, Pan Y, Sakurai K, Hikida T, Fukada Y, Takao T. Lithium ion adduction enables UPLC-MS/MS based analysis of multi-class, 3-hydroxyl group containing keto-steroids. Journal of Lipid Research, in press.

  3. Takei T, Ando h T, Takao T,Hojo H: One-pot four-segment ligation using seleno- and thioester and its application to the synthesis of superoxide dismutase. Angew Chem Int Ed Engl. 56, 15708-15711 (2017).

  4. Okumura N & Takao T: The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form. Biochem. Biophys. Res. Commun. 494, 484-490 (2017).

  5. Kobayashi S, Lee J, Takao T,Fujii J: Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice. Biochem Biophys Res Commun. 491 (3):649-655 (2017).

  6. Harada T, Yamamoto H, Kishida S, Kishida M, Awada C, Takao T,Kikuchi A: Wnt5b-associated exosomes promote cancer cell migration and proliferation. Cancer Sci. doi: 10.1111/cas.13109 (2016).

  7. Katano T, Fukuda M, Furue H, Yamazaki M, Abe M, Watanabe M, Nishida K,Yao I, YamadaA, Hata Y, Okumura N, Nakazawa T, Yamamoto T, SakimuraT, Takao T,Ito S: Involvement of brain-enriched guanylate kinase-associated protein (BEGAIN) in chronic pain after peripheral nerve injury. eNeuro, 3 (5). 0110-16 (2016).

  8. Kaimori JY, Maehara K, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T,Ohkawa Y, Kimura H, Isaka Y: Histone H4 lysine 20 acetylation is associated with gene repression in human cells. Sci Rep. 6: 24318 doi: 10.1038/srep24318 (2016).

  9. Okumura N, Tamura J, Takao T: Evidence for an Essential Role of Intradimer Interaction in Catalytic Function of Carnosine Dipeptidase II Using Electrospray-Ionization Mass Spectrometry. Protein Sci. Feb; 25 (2): 511-22 doi: 10.1002/pro.2842 (2016).

  10. Pereira D.C, Minamino N, Takao T: Free Thiol of Transthyretin in Human Plasma Most Accessible to Modification/Oxidation. Anal. Chem. 87 (21):10785-91 (2015).

  11. Sakakibara K, Eiyama A, Suzuki SW, Sakoh-Nakatogawa M, Okumura N, Tani M, Hashimoto A, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T,Ohsumi Y, Okamoto K (2015) Functional Link between Atg32-mediated Mitophagy and Phospholipid Methylation. EMBO J, 34 (21):2703-19 (2015).

  12. Asahina Y , Komiya S, Ohagi A, Fujimoto R, Tamagaki H, Nakagawa K, Sato T, Akira S, Takao T,Ishii A, Nakahara Y, Hojo H: Chemical Synthesis of O-Glycosylated Human Interleukin-2 by the Reverse Polarity Protection Strategy. Angewandte Chemie, International Edition in English, 54, 8226-8230 (2015).

  13. Yamamoto H, Awada C, Matsumoto S, Kaneiwa T, Sugimoto T, Takao T,and Kikuchi A: Basolateral secretion of Wnt5a in polarized epithelial cells is required for apical lumen formation. Journal of Cell Science, 129, 1051-1063 (2015).

  14. Iwasa C, Tonozuka T, Shinoda M , Sagane Y, Niwa K, Watanabe T, Yoshida H, Kamitori S, Takao T,Oguma K, and Nishikawa A. (2014) Purification, crystallization and preliminary X-ray analysis of an HA17-HA70 (HA2-HA3) complex from Clostridium botulinum type C progenitor toxin. Acta Crystallographica F. Structural Biology and Crystallization Communications, 70, 64-67

  15. Okumura N, Tsujihara M , Momohara C , Yoshioka I , Suto K , Nonomura N , Okuyama A , Takao T. (2013) Diversity in protein profiles of individual calcium oxalate kidney stones. PLoS One. 8, e68624

  16. Asahina Y , Kamitori S , Takao T, Nishi N , Hojo H (2013) Chemoenzymatic Synthesis of the Immunoglobulin Domain of Tim-3 Carrying a Complex-Type N-Glycan by Using a One-pot Ligation. Angew Chem Int Ed Engl. 52 (37):9733-9737.

  17. Kimura M , Okumura N , Kose S , Takao T, Imamoto N (2013) Identification of cargo proteins specific for importin-β with importin-α applying a stable isotope labeling by amino acids in cell culture (SILAC)-based in vitro transport system. J Biol Chem 288:24540-24549

  18. Yamamoto H, Awada C, Hanaki H , Sakane H , Tsujimoto I , Takahashi Y , Takao T, and Kikuchi A (2013) The apical and basolateral secretion of Wnt11 and Wnt3a in polarized epithelial cells is regulated by different mechanisms. Journal of Cell Science, 126, 2931-2943

  19. Yasui H , Yamazaki CM , Nose H , Awada C , Takao T, Koide T (2013) Potential of collagen-like triple helical peptides as drug carriers: Their in vivo distribution, metabolism and excretion profiles in rodents. Biopolymers doi: 10.1002/bip.22234

  20. Kimura M , Kose S , Okumura N , Imai K , Furuta M , Sakiyama N , Tomii K , Horton P, Takao T, Imamoto N. (2013) Identification of cargo proteins specific for the nucleocytoplasmic transport carrier transportin by combination of an in vitro transport system and stable isotope labeling by amino acids in cell culture (SILAC)-based quantitative proteomics. Mol Cell Proteomics 12,145-157.

  21. Aoki M , Suto K , Komastu M , Kamimura A , Morishita K , Yamasaki M , Takao T. (2012) Increasing effect of an oral intake of L-hydroxyproline on the soluble collagen content of skin and collagen fragments in rat serum. Biosci Biotechnol Biochem. 76, 1242-1244

  22. Fukuda M, Takao T (2012) Quantitative Analysis of Deamidation and Isomerization in β2-Microglobulin by 18O Labeling. Anal. Chem. 84, 10388-10394

  23. Lahiri S, Takao T,Devi PG, Ghosh S, Ghosh A, Dasgupta A, Dasgupta D. (2012) Association of aureolic acid antibiotic, chromomycin A3 with Cu (2+) and its negative effect upon DNA binding property of the antibiotic. Biometals. 25, 435-450

  24. Kim C, Aono S, Marubashi S, Wada H, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Okumura N, Takao T,Doki Y, Mori M, Nagano H. (2012) Significance of Alanine Aminopeptidase N (APN) in Bile in the Diagnosis of Acute Cellular Rejection After Liver Transplantation. J Surg Res. 175, 138-148.

  25. Charge state-selective separation of peptides by reversible modification of amino groups and strong cation-exchange chromatography: Evaluation in proteomic studies using peptide-centric database searches, Betancourt LH, Sánchez A, Pérez Y, Fernandez de Cossio J, Gil J, Toledo P, Iguchi S, Aimoto S, González LJ, Padrón G, Takao T,Besada V. , JOURNAL OF PROTEOMICS, 74 (10), 2210-2213, 2011年09月, 学術論文

  26. Affinity-Trap Polyacrylamide Gel Electrophoresis: A Novel Method of Capturing Specific Proteins by Electro-Transfer, Awada, C., Sato, T., Takao, T., 82, 755-761, 2010年02月, 学術論文

  27. CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock, Isojima Y, Nakajima M, Ukai H, Fujishima H, Yamada RG, Masumoto KH, Kiuchi R, Ishida M, Ukai-Tadenuma M, Minami Y, Kito R, Nakao K, Kishimoto W, Yoo SH, Shimomura K, Takao T,Takano A, Kojima T, Nagai K, Sakaki Y, Takahashi JS, Ueda HR., Proc Natl Acad Sci U S A., 106, 15744-9, 2009年05月, 学術論文

  28. Snapshot peptidomics of the regulated secretory pathway., Sasaki K. Satomi Y. Takao T. Minamino N., Mol Cell Proteomics, 8, 1638-1647, 2009年03月, 学術論文

  29. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation., Tokunaga F. Sakata S. Saeki Y. Satomi Y. Kirisako T. Kamei K. Nakagawa T. Kato M. Murata S. Yamaoka S. Yamamoto M. Akira S. Takao T. Tanaka K. Iwai K., Nat Cell Biol., 11, 123-132, 2009年02月, 学術論文

  30. Involvement of linear polyubiquitylation of NEMO in NF-κB activation, Fuminori Tokunaga, Shin-ichi Sakata, Yasushi Saeki, Yoshinori Satomi, Takayoshi Kirisako, Kiyoko Kamei, Tomoko Nakagawa, Michiko Kato, Shigeo Murata, Shoji Yamaoka, Masahiro Yamamoto, Shizuo Akira, Toshifumi Takao, Keiji Tanaka, Kazuiro Iwai, Nature Cell Biol., 11, 123-132, 2009年02月, http://www.nature.com/ncb/journal/v11/n2/abs/ncb1821.html, 学術論文

  31. Metalation States versus Enzyme Activities of Cu, Zn-Superoxide Dismutase Probed by Electrpspray Ionization Mass Spectrometry, Yamazaki Y., Takao T., Anal. Chem. 2008, 80, 8246-8252, 2008年08月, 学術論文

  32. Selective isolation of N-blocked peptides by isocyanate-coupled resin, T MIKAMI, T TAKAO, Ana. Chem., 79, 7910-7915, 2007年12月, 学術論文

  33. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy, T HANADA, NN NODA, Y SATOMI, Y ICHIMURA, Y FUJIOKA, T TAKAO, F INAGAKI, Y OHSUMI, J Biol Chem., 282, 37298-37302, 2007年11月, 学術論文

  34. Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2, H YAMAGUCHI, K SASAKI, Y SATOMI, T SHIMBARA, H KAGEYAMA, MS MONDAL, K TOSHINAI, Y DATE, LJ GONZALEZ, S SHIODA, T TAKAO, M NAKAZATO, N MINAMINO, J Biol Chem., 282, 26354-26360, 2007年08月, 学術論文

  35. A sequential program of dual phosphorylation of KaiC as a basis for circadian rhythm in cyanobacteria, T NISHIWAKI*, Y SATOMI*, Y KITAYAMA, K TERAUCHI, R KIYOHARA, T TAKAO, T KONDO, EMBO J., 26, 4029-4037, 2007年08月, 学術論文

  36. DNA binding and partial nucleoid localization of the chloroplast stromal enzyme ferredoxin:sulfite reductase., Sekine K., Fujiwara M., Nakayama M., Takao T., Hase T. and Sato N., FEBS Journal, 274, 2054-2069, 2007年04月, 学術論文

  37. Mono-unsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion, Takada R, Yoshimori S, Kurata T, Ueno N, Norioka S, Kondoh H, Takao T, Takada S, Developmental Cell, Vol. 11 No. 6 pp791-801, 2006年12月, 学術論文

  38. Farnesylation of Retinal Transducin Underlies Its Translocation during Light Adaptation, Kassai H, Aiba A, Nakao K, Nakamura K, Katsuki M, Xiong WH, Yau KW, Imai H, Shichida Y, Satomi Y, Takao T, Okano T, Fukada Y., Neuron, Aug 18;47 (4):529-39, 2005年09月, 学術論文

  39. Top-Down Analysis of Protein Isoprenylation by Electrospray Ionization Hybrid Quadrupole-TOF Tandem Mass Spectrometry, Kassai H., Satomi Y., Fukada Y., Takao T., Rapid Commun. Mass Spectrom., 19, 269-274, 2005年04月, 学術論文

  40. Accurate Mass Measurement in Nanoflow Electrospray Ionization Mass Spectrometry by Alternately Potentiating Sample and Reference Sprayers, Satomi Y., Kudo Y., Sasaki K., Hase T., Takao T., Rapid Commun. Mass Spectrom., 19, 540-546, 2005年04月, 学術論文

  41. Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin., Wada A, Wang AP, Isomoto H, Satomi Y, Takao T,Takahashi A, Awata S, Nomura T, Fujii Y, Kohno S, Okamoto K, Moss J, Millan JL, Hirayama T., Int J Med Microbiol, 294, 427-35, 2005年04月, 学術論文

  42. Isotopica: a tool for the calculation and viewing of complex isotopic envelopes., Fernandez-de-Cossio J, Gonzalez LJ, Satomi Y, Betancourt L, Ramos Y, Huerta V, Amaro A, Besada V, Padron G, Minamino N, Takao T., Nucleic Acid Research, 15:123, 173-9, 2004年07月, 学術論文

  43. Determination of endogenous peptides in the porcine brain: possible construction of peptidome, a fact database for endogenous peptides., Minamino N, Tanaka J, Kuwahara H, Kihara T, Satomi Y, Matsubae M, Takao T., Journal of Chromatography B, 792, 33-48, 2003年07月, 学術論文

  44. Mouse Apg16L, a novel WD-repeatprotein, target to the autophagic isolation membrane with the Apg12-Apg5conjugate., Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., Yoshimori T., Journal of Cell Science, 16, 1679-1688, 2003年04月, 学術論文

  45. Molecular cloning and characterization of TPP36 and itsisoform TPP32, novel substrates of Abl tyrosine Kinase., Tsuchiya, K., Kawano, Y., Kojima, T., Nagata, K., Takao, T., Okada, M.,Shinohara, H., Maki, K., Toyama-Sorimachi, N., Miyasaka, N., Watanabe, M.,Karasuyama, H., FEBS Letters, 537, 203-209, 2003年04月, 学術論文

  46. Involvement of Histone H1.2 in Apoptosis Induced by DNA Double-StrandBreaks., Konishi, A., Shimizu, S., Hirota, J., Takao, T., Fan, Y., Matsuoka, Y.Zhang, L., Yoneda, Y., Fujii, Y., Skoultchi, A.I., Tsujimoto, Y.:, Cell, 114, 673-688, 2003年04月, 学術論文

  47. Epsilon -N,N,N-trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry., Hirota J, Satomi Y, Yoshikawa K, Takao T., Rapid Communication in Mass Spectrometry, 17, 371-376, 2003年03月, 学術論文

  48. Association of Pasteurella multocida toxin with vimentin, Hiroaki Shime, Takahiro Ohnishi, Kaori Nagao, Kiyomasa Oka, Toshifumi Takao, Yasuhiko Horiguchi, Infect. Immun., 70, 6460-3, 2002年11月, 学術論文

  49. Analysis of themolecular construction of xylogalacturonan isolated from soluble soybeanpolysaccharides., Nakamura A, Furuta H, Maeda H, Takao T,Nagamatsu Y., Biosci. Biotechnol. Biochem., 66, 1155-1158, 2002年04月, 学術論文

  50. Interaction of the SH2 domain of Fyn with a cytoskeletal protein, b-adducin., Shima T., Okumura N., Takao T., Satomi Y., Okada M., Nagai K, Journal of Biological Chemistry, 276, 42233-42240, 2001年08月, 学術論文

  51. プロテオミクスに向けた質量分析法, 高尾敏文, Chromatography, 2001年04月, 学術論文

  52. Mousehomologue of coq7/clk-1, longevity gene in Caenorhabditis elegans, isessential for coenzyme Q synthesis, maintenance of mitochondrial integrity,and neurogenesis., Nakai, D., Yuasa, S., Takahashi M., Shimizu T., Asaumi S., Isono K., Takao T., Suzuki Y., Kuroyanagi H., Hirokawa K., Koseki H., Shirsawa T., Biochem. Biophys. Res. Commun., 289, 463-71, 2001年04月, 学術論文

  53. Dextranase (α-1,6glucan-6-glucanohydrolase) from Penicillium minioluteum expressed in Pichiapastoris: two host cells with minor differences in N-glycosylation., Betancourt, L., Garcia, R.., Gonzalez, L.J., Montesino, R., Quintero, O.,Takao, T., & Shimonishi, Y., Cremata, J., FEMS Yeast Res., 1, 151-160, 2001年04月, 学術論文

  54. O-Glycosylation of G-protein-coupled receptor, octopusrhodopsin, Direct analysis by FAB mass spectrometry., Nakagawa, M., Miyamoto, T., Kusakabe, R., Takasaki, S., Takao, T., Shichida,Y., Tsuda, M., FEBS Lett., 496, 19-24, 2001年04月, 学術論文

  55. Selective Isolation and identification of N-terminalblocked peptides from tryptic protein digests., Betancourt, L., Besada, V., Gonzalez, L.J., Morera, V., Padron, G., Takao, T., & Shimonishi, Y., J. Peptide Res., 57, 345-353, 2001年04月, 学術論文

  56. Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediatedby Toll-like receptor 2: Role of N-terminal hydrophobic portion in itsmultiple functions., Nishiguchi, M., Matsumoto, M., Takao, T., Hoshino, M., Shimonishi, Y.,Tsuji, S., Begum, N.A., Takeuchi, O., Akira, S., Toyoshima, K., & Seya, T., J. Immunology, 166, 2610-2616, 2001年04月, 学術論文

  57. Automated interpretation of low-energy collision-induced dissociation spectra by SeqMS, a software aid for de novo sequencing by tandem mass spectrometry., Fernandez-de-Cossio J, Gonzalez J, Satomi Y, Shima T, Okumura N, Besada V, Betancourt L, Padron G, Shimonishi Y, Takao T., Electrophoresis, 2000年05月, 学術論文

  58. Novel rearranged ions observed for protonated peptides via metastable decomposition in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry., Fang S, Takao T,Satomi Y, Mo W, Shimonishi Y., Journal of American society for mass spectrometry, 2000年04月, 学術論文

  59. Differentiaing α- and β-Aspartic Acids by Low-Energy Electrospray IonizationMass Spectrometry., Gonzalez, J., Shimizu, T., Satomi, T., Shirasawa, T., Betancourt, L.,Besada, V., Padron, G., Orlando, R., Shimonishi, Y., & Takao, T., Rapid Commun. Mass Spectrom., 2000年04月, 学術論文

  60. Sequencing of OxidizedMethionine-Containing Peptides for Protein Identification. Rapid Commun.Mass Spectrom., Mo, W., Ma, Y., Takao, T., & Neubert, T.A., Rapid Commun.Mass Spectrom., 2000年04月, 学術論文

  61. Chemical Structure of NuclearProteins Which Are Phosphorylated during Meiotic Maturation of StarfishOocytes., Matoba, K., Matsumoto, Y., Hongo, T., Nagamatsu, Y., Sugino, H., Shimizu,T., Takao, T., Shimonishi, Y., & Ikegami, S., Biochemistry, 2000年04月, 学術論文

  62. The reversible modification regulatesthe membrane-binding state of Apg8/Aut7 essential for autophagy and thecytoplasm to vacuole targetting pathway., Kirisako, T., Ichimura, Y., Ishihara, N., Mizushima, N., Takao, T., Ishii,T., Ohsumi, M.,Noda, T., & Ohsumi, Y., J. Cell Biol., 2000年04月, 学術論文

  63. Differentiating alpha- and beta-aspartic acids by electrospray ionization and low-energy tandem mass spectrometry, Gonzalez LJ, Shimizu T, Satomi Y, Betancourt L, Besada V, Padron G, Orlando R, Shirasawa T, Shimonishi Y, Takao T., Rapid Communication in Mass Spectrometry, 2000年04月, 学術論文

  64. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases., Kawabuchi M, Satomi Y, Takao T,Shimonishi Y, Nada S, Nagai K, Tarakhovsky A, Okada M., Nature, 2000年04月, 学術論文

  65. Novel Rearranged Ions Observed for Protonated Peptides via Metastable Decomposition in Matrix-Assisted laser Desorption/Ionization Time-of-Flight Mass Spectrometry. (共著), 高尾敏文, 11/,345-351, 11/,345-351, 2000年, 学術論文

  66. Transmembrane Phosphoprotein Cbp Regulates the Activities of Src-Family Tyrosine Kinases. (共著), 高尾敏文, 404/,999-1003, 404/,999-1003, 2000年, 学術論文

  67. Activation of Rho through a Cross-link with Polyamines Catalyzed by Bordetella Dermonecrotizing Toxin. (共著), 高尾敏文, 19/,521-530, 19/,521-530, 2000年, 学術論文

  68. Structural Characterization of Acetobacter Diazotropicus Levansucrase byMatrix-assisted Laser Desorption/Ionization Mass Spectrometry:Identification of an N-Terminal Blocking Group and a Free-thiol CysteineResidue., Betancourt, L., Takao, T., Hernandez, L., Padron, G., & Shimonishi, Y., J. Mass Spectrom., 1999年04月, 学術論文

  69. Metastable Decomposition of a Peptide Containing anOxidized Methionine (s) in Matrix-Assisted Laser Desorption IonizationTime-of-Flight Mass Spectrometry., Betancourt, L., Takao, T., Gonzalez, J., Reyes, O., Besada, V., Padron, G.,& Shimonishi, Y.:, Rapid Commun. Mass Spectrom., 1999年04月, 学術論文

  70. Structural Characterization of Chemically Derivatized Oligosaccharides byNanoflow Electrospray Ionization Mass Spectrometry., Mo, W., Sakamoto, H., Kagi, N., Nishikawa, A., Shimonishi, Y., & Takao, T., Anal. Chem., 1999年04月, 学術論文

  71. Structural Characterization of Chemically Derivatized Oligosaccharides byNanoflow Electrospray Ionization Mass Spectrometry., Mo, W., Sakamoto, H., Kagi, N., Nishikawa, A., Shimonishi, Y., & Takao, T., Anal. Chem., 1999年04月, 学術論文

  72. Complementary DNA Cloning and characterization of Ferredoxin Localized in bundle-sheath cells of maize leaves, Tomohiro Matsumura, Yoko Kimata-ariga, Hitoshi Sakakibara, Tatsuo Sugiyama, Hiroshi Murata, Toshifumi Takao, Yasutsugu Shimonishi, Toshiharu Hase, 119/,481-488, 119/,481-488, 1999年02月, 学術論文

  73. Keramamides M and N,Two New Cyclic Peptides with a Sulfate Ester from Theonella Sponge. (共著), 高尾敏文, 55/,12543-12548, 55/,12543-12548, 1999年, 学術論文

  74. Chloroplast Cpn20 Forms a Tetrameric Structure in Arabidopsis thaliana., 高尾敏文, 17/,467-477, 17/,467-477, 1999年, 学術論文

  75. Complementary DNA Cloning and Characterization of Ferredoxin Localized in Bundle-Sheath Cells of Maize Leaves., 高尾敏文, 119/,481-488, 119/,481-488, 1999年, 学術論文

  76. A Novel Endogeneous Inhibitor of Phenoloxidase from Musca domestica Has a Cystine Motif Commonly Found in Snail and Spider Toxins., 高尾敏文, 38/,2179-2188, 38/,2179-2188, 1999年, 学術論文

  77. Structural Characterization of Acetobacter Diazotropicus Levansucrase by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry : Identification of an N-Terminal Bloking Group and a Free-thiol Cysteine Residue., 高尾敏文, 34/,169-174, 34/,169-174, 1999年, 学術論文

  78. Metastable Decomposition of a Peptide Containing an Oxidized Methionine (s) in Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry., 高尾敏文, 13/,1075-1076, 13/,1075-1076, 1999年, 学術論文

  79. Structural Characterization of Chemically Derivatized Oligosaccharides by Nanoflow Electrospray Ionization Mass Spectrometry., 高尾敏文, 71/,4100-4106, 71/,4100-4106, 1999年, 学術論文

  80. Keramamides K, and L, New Cyclic Peptides Containing Unusual Tryptophan Residue from Theonella Sponge., 高尾敏文, 54/,6719-6724, 54/,6719-6724, 1998年, 学術論文

  81. Specific Isoprenyl Group Linked to Transducin gamma-Subunit is a Determinant of Its Unique Signaling Properties among G-Proteins., 高尾敏文, 37/,9843-9850, 37/,9843-9850, 1998年, 学術論文

  82. Structural Analysis of Oligosaccharides Derivatized with 4-Aminobenzoic Acid 2- (Diethylamino)ethyl Ester by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry., 高尾敏文, 70/,4520-4526, 70/,4520-4526, 1998年, 学術論文

  83. Automated Interpretation of High-Energy Collision-Induced Dissociation Spectra of Singly Protonated Peptides by SeqMS, a Software Aid for De Novo Sequencing by Tandem Mass Spectrometry., 高尾敏文, 12/,1867-1878, 12/,1867-1878, 1998年, 学術論文

  84. Keramamides K, and L, New Cyclic Peptides Containing Unusual Tryptophan Residue from Theonella Sponge, 高尾敏文, 54/,6719-6724, 54/,6719-6724, 1998年, その他

  85. Specific Isoprenyl Group Linked to Transducin gamma-Subunit is a Determinant of Its Unique Signaling Properties among G-Proteins, 高尾敏文, 37/,9843-9850, 37/,9843-9850, 1998年, その他

  86. The Use of Capillary Liquid Chromatograph/Electrospray Mass Spectrometry to Identify a Specific Cysteine Residue Susceptible to S-Thiolation in Recombinant Human Cu, Zn Superoxide Dismutase, 高尾敏文, 1/,205-217, 1/,205-217, 1997年, その他

  87. Accurate Peptide Sequencing by Post-Source Decay Matrix-Assisted Laser desorption/Ionization time-of-Flight Mass Spectrometry, 高尾敏文, 11/,1829-1834, 11/,1829-1834, 1997年, その他

  88. Structure of a Covalently Cross-linked Form of Core Histone Present in the Starfish Sperm, 高尾敏文, 36/,12071-12079, 36/,12071-12079, 1997年, その他

  89. Isolation of Bioactive Compounds from Helix aspersa Nerve Tissue and the Effect of pQPPLPRYamide on Heart, Esophagus and Central Neurons of H. aspersa and Rectum of Anodonta woodiana, 高尾敏文, 29/,103-111, 29/,103-111, 1997年, その他

  90. A Novel Modification of the Lysine Residue at Position 12 of Histone H4 in Starfish Sperm, 高尾敏文, 61/,2151-2152, 61/,2151-2152, 1997年, その他

  91. Arachidonate 12-lipoxygenases. Catalytic properties and regulation of the enzyme gene, 高尾敏文, 407/,191-196, 407/,191-196, 1997年, その他

  92. The Oxidation of Selenocysteine is Involved in the Inactivation of Glutathione Peroxidase by Nitric oxide Donor, 高尾敏文, 272/,19152-19157, 272/,19152-19157, 1997年, 学術論文

  93. High-Sensitivity Mass Spectrometry for Analysis of Post-translatinal Modifications (共著), 高尾敏文, 16/,409-413, 16/,409-413, 1997年, 学術論文

  94. Identification of Two Palmityl Groups in Octopus Rhodopsin (共著), 高尾敏文, 65/,187-191, 65/,187-191, 1997年, 学術論文

  95. Identification of the Functional Region on the Superantigen Yersinia pseudotuberculosis-derived Mitogen Responsible for Induction of Lymphocyte Proliferation by Using Synthetic Peptides (共著), 高尾敏文, 390/,196-198, 390/,196-198, 1996年, 学術論文

  96. Molecular Identification and Characterization of Cytosolic Isoforms of Glutamine Synthetase in Maize Roots (共著), 高尾敏文, 271/,29561-29568, 271/,29561-29568, 1996年, 学術論文

  97. 質量分析による蛋白質の構造解析, 高尾敏文, 68/,1-13, 68/,1-13, 1996年, 学術論文

  98. 磁場型質量分析計を用いた蛋白質のキャピラリーHPLC/ エレクトロスプレーイオン化質量分析, 高尾敏文, /36,1-6, /36,1-6, 1996年, その他

  99. Effect of the Position of a Basic Amino Acid on C-Terminal Rearrangement of Protonated Peptides Upon Collision-induced Dissociation (共著), 高尾敏文, 31/,150-158, 31/,150-158, 1996年, 学術論文

  100. Suicide Inactivation of Porcine Leukocyte 12-Lipoxygenase Associated with Its Incorporation of 15-Hydroperoxy-5, 8, 11, 13-eicosatetraenoic Acid Derivative (共著), 高尾敏文, 1300/,56-62, 1300/,56-62, 1996年, 学術論文

  101. Sensitive Analysis of Oligosaccharides Derivatized with 4-Aminobenzoic Acid 2- (Diethylamino)ethyl Ester by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry (共著), 高尾敏文, 10/,637-640, 10/,637-640, 1996年, 学術論文

  102. Preparation and Characterization of Monoclonal Antibodies Specific for Lauroylated Isoform of Bivube Transducin α-Subunit : Immunohistochemical Analysis of Bovine Retinas (共著), 高尾敏文, 66/,2811-2196, 66/,2811-2196, 1996年, 学術論文

  103. Keramides E, G, H, and J, New Cyclic Peptides Containing an Oxazole or a Thiazole Ring from a Theonella Sponge (共著), 高尾敏文, 51/,2525-2532, 51/,2525-2532, 1995年, 学術論文

  104. Role of Heterogeneous N-Terminal Acylation of Recover in in Rhodops in Phosphorylation (共著), 高尾敏文, 270/,15459-15462, 270/,15459-15462, 1995年, 学術論文

  105. The Nuclear Pore-Targeting Complex Binds to Nuclear Pores after Association with a Karyophi (共著), 高尾敏文, 368/,415-419, 368/,415-419, 1995年, 学術論文

  106. O-Glycosylation of the Thr┣D170┫D1 Residue of Cell Adhesive Lysozyme in Yeast (共著), 高尾敏文, 230/,965-970, 230/,965-970, 1995年, 学術論文

  107. In Vivo Evidence for Involvement of a 58 kDa Component of Nuclear Pore-Targeting Complex in Nuclear Protein Import (共著), 高尾敏文, 14/,3617-3626, 14/,3617-3626, 1995年, 学術論文

  108. Use of the Derivatizing Agent, 4-Aminobenzoic Acid 2- (Diethylation)ethyl Ester of High-Sensitivity Detection of Oligosaccharides by Electrospray Lonization Mass Spectrometry (共著), 高尾敏文, 67/,4028-4031, 67/,4028-4031, 1995年, 学術論文

  109. Primary Structure of a Novel Potent Endogenous DOPA-Containing Inhibitor of Phenoloxidase from Musca domestica., 高尾敏文, 92/,2964-2968, 92/,2964-2968, 1995年, その他

  110. Characterization of a Highly Toxic, Large Molecular Size Heat-Stable Enterotoxin Produced by a Clinical Isolate of Yersinia enterocolitica., 高尾敏文, 362/,319-322, 362/,319-322, 1995年, 学術論文

  111. Purification and Characterization of a Novel Superantigen Produced by a Clinical Isolate of Yersinia pseudotuberculosis., 高尾敏文, 356/,141-144, 356/,141-144, 1994年, 学術論文

  112. Positive-Ion Fast Atom Bombardment Tandem Mass Spectrometry of Peptide Nucleic Acids., 高尾敏文, 8/,925-928, 8/,925-928, 1994年, 学術論文

  113. Characterization of Interactions between Transducin α/βγ-Subunits and Lipid Membranes., 高尾敏文, 269/,30358-30363, 269/,30358-30363, 1994年, 学術論文

  114. Activation Peptide of Human Factor IX Has Oligosaccharides O-Glycosidically Linked to Threonine residues at 159 and 169., 高尾敏文, 33/,5167-5171, 33/,5167-5171, 1994年, 学術論文

  115. Optimization of Skimmer Voltages of an Electrospray Ion Source Coupled with a Magnetic Sector Instrument., 高尾敏文, 8/,205-210, 8/,205-210, 1994年, 学術論文

  116. Effects of Carboxyl Methylation of Photoreceptor G Protein γ-Subunit in Visual Transduction., 高尾敏文, 269/,5163-5170, 269/,5163-5170, 1994年, 学術論文

  117. On-Line Membrane Blotting of Peptides and Proteins from a Capillary Column. (共著), 高尾敏文, 210,206-8, 210,206-8, 1993年, 学術論文

  118. A New Lipopeptide Biosurfactant Produced by Arthrobacter sp. Strain MIS38. (共著), 高尾敏文, 175,6459-6466, 175,6459-6466, 1993年, 学術論文

  119. Primary Structure of Microbial Transglutaminase from Streptoverticilliumsp. Strain S-8112. (共著), 高尾敏文, 268,11565-11572, 268,11565-11572, 1993年, 学術論文

  120. Purification and Sequence Determination of Heat-Stable Enterotoxin elabolated by a Cholera Toxin-Producing Strain of Vibrio cholerae 01. (共著), 高尾敏文, 326,83-86, 326,83-86, 1993年, 学術論文

  121. Human Factor IX Has a Tetrasaccharide 0-Glycosidically Linked to Serine 61 through the Fucose Residue., 高尾敏文, 267,17520-17525, 267,17520-17525, 1992年, 学術論文

  122. A Method for Determination of N-Glycosylation Sites in Glycoproteins by Collision-Induced Dissociation Analysis in Fast Atom Bombardment Mass Spectrometry : Identification of the Positions of Carbohydrate-Linked Asn in a Recombinant α-Amylase by Treatment with Peptide : N-Glycosidase F in 180-Labeled Water. (共著), 高尾敏文, 205,151-158, 205,151-158, 1992年, 学術論文

  123. FAB質量分析の実際とペプチド・蛋白質一次構造解析への応用, 高尾敏文, 32/179, 32/179, 1992年, 学術論文

  124. Facile Assignment of Sequence Ions of a Peptide Labelled with ┣D118┫D10 at the Carboxyl Terminus. (共著), 高尾敏文, 5,312-315, 5,312-315, 1991年, 学術論文

  125. Identification of a Novel Amino Acid, o-Bromo-L-Phenylalanine, in Egg-Associated Peptides that Activate Spermatozoa. (共著), 高尾敏文, 30,6203-6209, 30,6203-6209, 1991年, 学術論文

  126. Carboxyl Methylation and Farnesylation of Transducin Gamma-Subunit Synergistically Enhance Its Coupling with Metarhodopsin II, 高尾敏文, 10/12, 10/12, 1991年, 学術論文

  127. Analysis of Post-Translational Modifications of Proteins by Accurate Mass Measurement in Fast Atom Bombardment Mass Spectrometry, 高尾敏文, 19, 19, 1990年, 学術論文

  128. Identification of a Disaccharide (Xyl-Glc) and a Trisaccharide (Xyl2-Glc)0-Glycosidically Linked to a Serine Residue in the First Epidermal Growth Factor-Like Domain of Human Factors VII and IX and Protein Z and Bovine Protein Z. (共著), 高尾敏文, 264/20320-20325, 264/20320-20325, 1989年, 学術論文

  129. CHEMICAL CHARACTERIZATION OF HAET-STABLE ENTEROTOXIN ORIGINATED FROM YERSINIA ENTEROCOLITICA, Toshifumi Takao, Noriko Tominaga, Shoko Yoshimura, Saburo Aomoto, Yasutsugu Shimonishi, Takashi Inoue, and Akio Miyama, Advances in Research on Cholera and Related Diarrheas,4,291-303 (1988), 4,291-303, 1988年04月, 学術論文

  130. 質量分析によるタンパク質の一次構造解析, 高尾敏文, 41, 41, 1988年, 学術論文

  131. Chemical Characterization of Recombinant Human Leukocyte Interferon A Using Fast Atom Bombardment Mass Spectrometry, 高尾敏文, 262, 262, 1987年, 学術論文

  132. Isolation, primary structure and synthesis of heat-stable enterotoxin produced by Yersinia enterocolitica, Toshifumi Takao, Noriko TOMINAGA, Shoko YOSHIMURA, Yasutsugu SHIMONISHI, Saburo HARA, Takashi INOUE and Akio MIYAMA, Eur.J.Biochem.152 199-206 (1985), 199-206, 1985年01月, 学術論文

  133. Verification by Mass Spectrometry of the Primary Structure of Human Interleukin-2, 高尾敏文, 260, 260, 1985年, 学術論文

  134. Chemical Synthesis of Fully Active and Heat-stable Fragments of Heat-stable Enterotoxin of Enterotoxigenic Escherichia coli Strain 18D, S. Yoshimura, T. Takao, H. Ikemura, S. Aimoto, Y. Shimonishi, S. Hara, T. Takeda, Y. Takeda and T. Miwatani, Bull. Chem. Soc. Jpn., 57, 1381-1387 (1984), 57, 1381-1387, 1984年05月, 学術論文

  135. Verification of Protein Sequence by Fast Atom Bombardment Mass Spectrometry (Amino Acid Sequence of Protein S, A Development-Specific Protein), 高尾敏文, 259, 259, 1984年, 学術論文

  136. Neutralization of Activity of Two Different Heat-stable Enterotoxins (STh and STp) of Enterotoxigenic Escherichia coli by Homologous and Heterologous Antisera, T. Takeda, Y. Takeda, S. Aimoto, T. Takao, H. Ikemura, Y. Shimonishi and T. Miwatani, FEMS Microbiology Letters, 20, 357-359 (1983), 20, 357-359, 1983年12月, 学術論文

  137. Simultaneous Analysis of C-Terminal Amino Acid Residues of Peptide Mixtures by Combination of Field Desorption Mass Spectrometry and Carboxypeptidase Digestion, Y. -M. Hong, T. Takao, S. Aimoto and Y. Shimonishi, Biomedical Mass Spectrometry, 10, 450-457 (1983), 10, 450-457, 1983年08月, 学術論文

  138. Amino-Acid Sequence of a Heat-stable Enterotoxin Produced by Human Enterotoxigenic Escherichia coli, S. Aimoto, T. Takao, Y. Shimonishi, S. Hara, T. Takeda, Y. Takeda and T. Miwatani, Eur. J. Biochem. 129, 257-263 (1982), 129, 257-263, 1982年12月, 学術論文

  139. Computation of Amino Acid Sequences of Polypeptides from Masses of Their Constituent Peptide Fragments and Amino Acid Residues Released in Edman-Degradation, T. Kitagishi, Y. -M. Hong, T. Takao, S. Aimoto and Y. Shimonishi, Bull. Chem. Soc. Jpn., 55, 575-580 (1982), 55, 575-580, 1982年02月, 学術論文

  140. A New Method for Carboxyl-Terminal Sequence Analysis of a Peptide Using Carboxypeptidases and Field-Desorption Mass Spectrometry, Y. Shimonishi, Y. -M. Hong, T. Takao, S. Aimoto, H. Matsuda and Y. Izumi, Proc. Jpn. Acad.,57B, 304-308 (1981), 304-308, 1981年08月, 学術論文