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【Research Programs】 1) Development of chemical/analytical methods and software for analysis of protein primary structure 2) Development of chemical and analytical methods for proteomics and search for biomarkers 3) MS analysis of post-translational modifications 4) Development of a chemical derivatization method for high sensitive detection of sugar chains 5) Hardware development for high-sensitivity MS 6) Study on fragmentation of peptides and carbohydrates in MS
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Mass spectrometry (MS) is well accepted technique for the analyses of chemical structures of biological compounds. We have been working to develop methods for determining primary structures and post-translational modifications of proteins by using MS. In conjunction with accumulating protein and gene sequence databases, we are using state-of-the-art MS for large-scale protein identification which is indispensable for proteomics research. We also apply the above developed methods to the structural analysis of micro quantities of peptides, proteins, and their related substances.
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