{"id":354,"date":"2015-04-08T21:51:21","date_gmt":"2015-04-08T12:51:21","guid":{"rendered":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/?page_id=354"},"modified":"2015-12-03T19:15:17","modified_gmt":"2015-12-03T10:15:17","slug":"kakuyusou","status":"publish","type":"page","link":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/research\/theme\/kakuyusou\/","title":{"rendered":"\u6838\u8f38\u9001\u8907\u5408\u4f53\u306e\u69cb\u9020\u751f\u547d\u79d1\u5b66\u7814\u7a76"},"content":{"rendered":"<p>\u7d30\u80de\u306e\u300c\u6838\uff08\u7d30\u80de\u6838\uff09\u300d\u306f\uff0c\u771f\u6838\u751f\u7269\u306b\u56fa\u6709\u306e\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u306e\u4e00\u3064\u3067\u907a\u4f1d\u60c5\u5831\u3092\u53f8\u308b\u5206\u5b50\u3067\u3042\u308b DNA \u3092\u542b\u3093\u3067\u3044\u307e\u3059\uff0e\u6838\u3068\u7d30\u80de\u8cea\u306e\u9593\u306f\u6838\u819c\u3067\u4ed5\u5207\u3089\u308c\u3066\u3044\u3066\uff0c\u6838\u819c\u5b54\u3068\u547c\u3070\u308c\u308b\u300c\u7a74\u300d\u3092\u901a\u3057\u3066\u86cb\u767d\u8cea\u3084 RNA \u306a\u3069\u304c\u79fb\u52d5\u3057\u307e\u3059\uff0e\u3053\u306e\u6642\uff0c\u30a4\u30f3\u30dd\u30fc\u30c1\u30f3\u3084\u30a8\u30af\u30b9\u30dd\u30fc\u30c1\u30f3\u3068\u3044\u3063\u305f\u8f38\u9001\u86cb\u767d\u8cea\u3068\u8907\u5408\u4f53\u3092\u4f5c\u308b\u3053\u3068\u3067\uff0c\u7279\u5b9a\u306e\u5206\u5b50\u304c\u904b\u3070\u308c\u307e\u3059\uff0e\u8f38\u9001\u86cb\u767d\u8cea\u304c\u7a4d\u307f\u8377\u3067\u3042\u308b\u86cb\u767d\u8cea\u3084\u6838\u9178\u3092\u3069\u306e\u3088\u3046\u306b\u8a8d\u8b58\u3059\u308b\u304b\u3068\u3044\u3046\u4ed5\u7d44\u307f\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\uff0e<\/p>\n<p><strong>RNA\u306e\u6838\u304b\u3089\u7d30\u80de\u8cea\u3078\u306e\u79fb\u52d5\u306b\u95a2\u3059\u308b\u69cb\u9020\u7814\u7a76<\/strong><\/p>\n<div style=\"width: 200px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-content\/uploads\/2015\/04\/fig1-862x1024.jpg\" alt=\"fig1\" width=\"190\" height=\"225\" \/><p class=\"wp-caption-text\">\u56f31. pre-microRNA\u3092\u3068\u3089\u3048\u305fexportin-5\/RanGTP\u306e\u30df\u30c3\u30c8\u69cb\u9020<\/p><\/div>\n<p>\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u306b\u5fc5\u9808\u306etRNA\u3084RNA\u5e72\u6e09\u306e\u4e3b\u5f79\u3067\u3042\u308bmicroRNA\u306a\u3069\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u304c\u751f\u547d\u306e\u7dad\u6301\u306b\u91cd\u8981\u306a\u50cd\u304d\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u306f\u6838\u5185\u3067\u8ee2\u5199\u3055\u308c\u3001\u6838\u304b\u3089\u305d\u308c\u305e\u308c\u306e\u50cd\u304d\u306e\u5834\u3067\u3042\u308b\u7d30\u80de\u8cea\u306b\u904b\u3070\u308c\u307e\u3059\u3002tRNA\u3084microRNA\u306e\u6838\u2014\u7d30\u80de\u8cea\u9593\u8f38\u9001\u3067\u8f38\u9001\u86cb\u767d\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u306e\u304c\u3001importin-\u03b2\u30d5\u30a1\u30df\u30ea\u30fc\u306eexportin-5\u3067\u3042\u308a\u307e\u3059\u3002exportin-5\u306f\u591a\u7a2e\u306e\u5c0f\u3055\u306a\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u3092\u8a8d\u8b58\u3057\u8f38\u9001\u3057\u307e\u3059\u3002\u3053\u306e\u8f38\u9001\u86cb\u767d\u8ceaexportin-5\u304c\u7a4d\u307f\u8377\u3067\u3042\u308b\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u3092\u3069\u306e\u3088\u3046\u306b\u8a8d\u8b58\u3059\u308b\u304b\u3068\u3044\u3046\u4ed5\u7d44\u307f\u3092\u69cb\u9020\u7684\u898b\u5730\u304b\u3089\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001\u7a4d\u307f\u8377\u5206\u5b50\u3068\u306e\u8907\u5408\u4f53\u306e\u7d50\u6676\u69cb\u9020\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306b\u3001RNA\u5e72\u6e09\u306e\u4e3b\u5f79\u3067\u3042\u308bmicroRNA\u3068\u306e\u8907\u5408\u4f53\u306e\u69cb\u9020\u89e3\u6790\u306b\u6210\u529f\u3057\u3001exportin-5\u304c\u3001pre-microRNA\u306e\u7279\u5fb4\u7684\u306a\u69cb\u9020\u3067\u3042\u308b3\u2019\u672b\u7aef\u306e\u7a81\u51fa\u3057\u305f\u5869\u57fa\u3092\u8a8d\u8b58\u3057\u3001\u30df\u30c3\u30c8\u69cb\u9020\u3067pre-microRNA\u3092\u7de9\u304f\u63b4\u3093\u3067\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><strong>\u8ee2\u5199\u56e0\u5b50\u306e\u7d30\u80de\u8cea\u304b\u3089\u6838\u3078\u306e\u79fb\u52d5\u306b\u95a2\u3059\u308b\u69cb\u9020\u7814\u7a76<\/strong><\/p>\n<div style=\"width: 200px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-content\/uploads\/2015\/12\/impb-srebp2.gif\" alt=\"\" width=\"190\" height=\"168\" \/><p class=\"wp-caption-text\">\u56f32. \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u8ee2\u5199\u56e0\u5b50SREBP-2\u3092\u3068\u3089\u3048\u305fimportin-beta\u306e\u69cb\u9020<\/p><\/div>\n<p>\u8ee2\u5199\u56e0\u5b50\u306f\u7d30\u80de\u8cea\u3067\u30ea\u30dc\u30bd\u30fc\u30e0\u306b\u3088\u3063\u3066\u5408\u6210\u3055\u308c\u307e\u3059\u3002\u5408\u6210\u3055\u308c\u305f\u8ee2\u5199\u56e0\u5b50\u306f\u3001\u6a5f\u80fd\u3059\u308b\u5834\u3067\u3042\u308b\u6838\u3078\u3068\u79fb\u52d5\u3057\u307e\u3059\u3002\u3053\u306e\u79fb\u52d5\u306b\u95a2\u308f\u308b\u306e\u304c\u3001importin-\u03b1\u53ca\u3073importin-\u03b2\u3067\u3042\u308a\u307e\u3059\u3002\u8ee2\u5199\u56e0\u5b50\u306fimportin-\u03b1\u306b\u3088\u308a\u8a8d\u8b58\u3055\u308c\u3001importin-\u03b2\u306b\u3088\u3063\u3066\u6838\u3078\u3068\u904b\u3070\u308c\u307e\u3059\u3002\u3053\u308c\u3089\u8f38\u9001\u86cb\u767d\u8cea\u304c\u6838\u3078\u306e\u8f38\u9001\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u7d30\u80de\u306e\u6a5f\u80fd\u304c\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304d\u3066\u3044\u307e\u3059\u3002importin-\u03b1\u3084importin-\u03b2\u304c\u7a4d\u307f\u8377\u3067\u3042\u308b\u8ee2\u5199\u56e0\u5b50\u3092\u3069\u306e\u3088\u3046\u306b\u8a8d\u8b58\u3057\u3001\u5fc5\u8981\u306a\u6642\u306b\u6838\u3078\u8f38\u9001\u3059\u308b\u306e\u304b\u3068\u3044\u3046\u4ed5\u7d44\u307f\u3092\u69cb\u9020\u7684\u898b\u5730\u304b\u3089\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u3001\u69d8\u3005\u306a\u8ee2\u5199\u56e0\u5b50\u3068\u306e\u8907\u5408\u4f53\u306e\u7d50\u6676\u69cb\u9020\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u307e\u3067\u306b\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee3\u8b1d\u306b\u95a2\u308f\u308b\u8ee2\u5199\u56e0\u5b50\u3068\u8f38\u9001\u62c5\u4f53importin-\u03b2\u3068\u306e\u8907\u5408\u4f53\u306eX\u7dda\u7d50\u6676\u69cb\u9020\u89e3\u6790\u306b\u6210\u529f\u3057\u3001\u8f38\u9001\u62c5\u4f53\u304c\u8ee2\u5199\u56e0\u5b50\u3092\u8a8d\u8b58\u3057\u52b9\u7387\u3088\u304f\u904b\u3076\u4ed5\u7d44\u307f\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<p><strong>Reference<\/strong><\/p>\n<ul>\n<li>C. Okada <em>et al.<\/em>, Science, <strong>326<\/strong>, 1275-1279 (2009).<\/li>\n<li>S. J. Lee <em>et al.<\/em>, Science, <strong>302<\/strong>, 1571-1575 (2003).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7d30\u80de\u306e\u300c\u6838\uff08\u7d30\u80de\u6838\uff09\u300d\u306f\uff0c\u771f\u6838\u751f\u7269\u306b\u56fa\u6709\u306e\u7d30\u80de\u5185\u5c0f\u5668\u5b98\u306e\u4e00\u3064\u3067\u907a\u4f1d\u60c5\u5831\u3092\u53f8\u308b\u5206\u5b50\u3067\u3042\u308b DNA \u3092\u542b\u3093\u3067\u3044\u307e\u3059\uff0e\u6838\u3068\u7d30\u80de\u8cea\u306e\u9593\u306f\u6838\u819c\u3067\u4ed5\u5207\u3089\u308c\u3066\u3044\u3066\uff0c\u6838\u819c\u5b54\u3068\u547c\u3070\u308c\u308b\u300c\u7a74\u300d\u3092\u901a\u3057\u3066\u86cb\u767d\u8cea\u3084 RNA \u306a\u3069\u304c\u79fb\u52d5\u3057\u307e\u3059\uff0e\u3053\u306e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"ja","_original_post":"354","footnotes":""},"class_list":["post-354","page","type-page","status-publish","hentry","ja"],"_links":{"self":[{"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/pages\/354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/comments?post=354"}],"version-history":[{"count":2,"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/pages\/354\/revisions"}],"predecessor-version":[{"id":635,"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/pages\/354\/revisions\/635"}],"up":[{"embeddable":true,"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"http:\/\/www.protein.osaka-u.ac.jp\/rcsfp\/supracryst\/wp-json\/wp\/v2\/media?parent=354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}