Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis
Hasegawa, K., Kawahara, T., Fujiwara, K., Shimpuku, M., Sasaki, T., Kitamura, T. & Yoshikawa, K.
J. Neurosci. 32: 5562-5572 (2012)
Dynamic expression of the pro-dopaminergic transcription factors Pax6 and Dlx2 during postnatal olfactory bulb neurogenesis.
de Chevigny, A., Core, N., Follert, P., Wild, S., Bosio, A., Yoshikawa, K., Cremer, H. & Beclin, C.
Front. Cell. Neurosci. 6:6 (2012)
Necdin controls proliferation of white adipocyte progenitor cells.
Fujiwara, K., Hasegawa, K., Ohkumo, T., Miyoshi, H., Tseng, Y-H. & Yoshikawa, K.
PLoS One 7(1): e30948 (2012)
Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis.
Tepavcevic, V., Lazarini, F., Alfaro-Cervello, C., Kerninon, C., Yoshikawa, K., Garcia-Verdugo, J. M., Lledo, P. M., Nait-Oumesmar, B. & Baron-Van Evercooren, A.
J. Clin. Invest. 121: 4722-4734 (2011)
The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.
Zhong, J., Kim, H. T., Lyu, J., Yoshikawa, K., Nakafuku, M. & Lu, W.
Development 138: 409-419 (2011)
Neural stem cell-like gene expression in a mouse ependymoma cell line transformed by human BK polyomavirus.
Aizawa, T., Hasegawa, K., Ohkumo, T., Haga, S., Ikeda, K. & Yoshikawa, K.
Cancer Sci. 102:122-129 (2011)
Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes.
Wu, H., Coskun, V., Tao, J., Xie, W., Ge, W., Yoshikawa, K., Li, E., Zhang, Y. & Sun, Y. E.
Science 329: 444-448 (2010)
Necdin promotes tangential migration of neocortical interneurons from basal forebrain.
Kuwajima, T., Hasegawa, K. & Yoshikawa, K.
J. Neurosci. 30: 3709-3714 (2010)
Extracerebellar progenitors grafted to the neurogenic milieu of the postnatal rat cerebellum adapt to the host environment but fail to acquire cerebellar identities.
Rolando, C., Gribaudo, S., Yoshikawa, K., Leto, K., De Marchis, S. & Rossi, F.
Eur. J. Neurosci. 31: 1340-1351(2010)
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.
Gajera, C. R., Emich, H., Lioubinski, O., Christ, A., Beckervordersandforth-Bonk, R., Yoshikawa, K., Bachmann, S., Christensen, E. I., Gotz, M., Kempermann, G., Peterson, A. S., Willnow, T. E. & Hammes, A.
J. Cell Sci. 123: 1922-1930 (2010)
Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration.
Kubota, Y., Osawa, M., Jakt, LM., Yoshikawa, K. & Nishikawa, S-I.
Blood 114: 4383-4392 (2009)
Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm.
Liu, X., Wang, Y., Zhang, Y., Zhu, W., Xu, X., Niinobe, M., Yoshikawa, K., Lu, C. & He, C.
Mol. Cell. Neurosci. 41: 51-61 (2009)
Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.
Hasegawa, K. & Yoshikawa, K.
J. Neurosci. 28: 8772-8784 (2008)
Drosophila MAGE controls neural precursor proliferation in postembryonic neurogenesis.
Nishimura, I., Sakoda, J-Y. & Yoshikawa, K.
Neuroscience 154:572-581(2008)
Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation.
Long, J. E., Garel, S., Alvarez-Dolado, M., Yoshikawa, K., Osumi, N., Alvarez-Buylla, A. & Rubenstein, J. L.
J. Neurosci. 27:3230-3243 (2007)
Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins.
Lopez-Sanchez, N., Gonzalez-Fernandez, Z., Niinobe, M., Yoshikawa, K. & Frade. J.M.
Physiol. Genomics 30:156-171(2007)
Expression of Drosophila MAGE gene encoding a necdin homologous protein in postembryonic neurogenesis.
Nishimura, I., Shimizu, S., Sakoda, J-Y. & Yoshikawa, K.
Gene Expr. Patterns 7:244-251(2007)Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.
Kuwajima, T., Nishimura, I. & Yoshikawa, K.
J. Neurosci. 26:5383-5392 (2006)Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue.
Goldfine, A.B., Crunkhorn, S., Costello, M., Gami, H., Landaker, E.J., Niinobe, M., Yoshikawa, K., Lo, D., Warren, A., Jimenez-Chillaron, J. & Patti, M.E.
Diabetes 55:640-650 (2006)Necdin downregulates Cdc2 expression to attenuate neuronal apoptosis.
Kurita, M., Kuwajima, T., Nishimura, I. & Yoshikawa, K.
J. Neurosci. 26:12003-12013 (2006)Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival.
Kuwako, K., Hosokawa, A., Nishimura, I., Uetsuki, T., Yamada, M., Nada, S., Okada, M. & Yoshikawa, K.
J. Neurosci. 25: 7090-7099 (2005)Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.
Tseng, Y. H., Butte, A. J., Kokkotou, E., Yechoor, V. K., Taniguchi, C. M.Kriauciunas, K. M., Cypess, A. M., Niinobe, M., Yoshikawa, K., Patti, M. E. & Kahn, C. R.
Nature Cell Biol. 7: 601-611 (2005)Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression.
Taniura, H., Kobayashi, M. & Yoshikawa, K.
J. Cell. Biochem. 94:804-815 (2005)Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor.
Kuwako, K., Taniura, H. & Yoshikawa, K.
J. Biol. Chem. 279:1703-1712 (2004)Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells.
Kuwajima, T., Taniura, H., Nishimura, I. & Yoshikawa, K.
J. Biol. Chem. 279:40484-40493 (2004)Msx2 and necdin combined activities are required for smooth muscle differentiation in mesoangioblast stem cells.
Brunelli, S., Tagliafico, E., De Angelis, F.G., Tonlorenzi, R., Baesso, S., Ferrari, S., Niinobe, M., Yoshikawa, K., Schwartz, R.J., Bozzoni. I. & Cossu, G.
Circ. Res. 94:1571-1578 (2004)Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas.
Hoek, K., Rimm, D.L., Williams, K.R., Zhao, H., Ariyan, S., Lin, A., Kluger, H.M., Berger, A.J., Cheng, E., Trombetta, E.S., Wu, T., Niinobe, M., Yoshikawa, K., Hannigan, G.E. & Halaban, R.
Cancer Res. 64:5270-5282 (2004)Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.
Taru, H., Yoshikawa, K. & Suzuki, T.
FEBS Lett. 567:248-252 (2004)Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons.
Nishimura, I., Takazaki, R., Kuwako, K., Enokido, Y. & Yoshikawa, K.
Exp. Cell Res. 286:241-251 (2003)Cell death induced by a caspase-cleaved transmembrane fragment of the Alzheimer amyloid precursor protein.
Nishimura, I., Uetsuki, T., Kuwako, K., Hara, T., Kawakami, T., Aimoto, S. & Yoshikawa, K.
Cell Death Differ. 9:199-208 (2002)Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein.
Kuwako, K., Nishimura, I., Uetsuki, T., Saido, T.C., & Yoshikawa, K.
Brain Res. Mol. Brain Res. 107:166-175 (2002)Necdin interacts with the ribonucleoprotein hnRNP U in the nuclear matrix.
Taniura, H. & Yoshikawa, K.
J. Cell. Biochem. 84:545-555 (2002)Necdin is required for terminal differentiation and survival of primary dorsal root ganglion neurons.
Takazaki, R., Nishimura, I. & Yoshikawa, K.
Exp. Cell Res. 277:220-232 (2002)Ectopic expression of necdin induces differentiation of mouse neuroblastoma cells.
Kobayashi, M., Taniura, H. & Yoshikawa, K.
J. Biol. Chem. 277:42128-42135 (2002)The p75 Neurotrophin Receptor Interacts with Multiple MAGE Proteins .
Tcherpakov, M., Bronfman, F. C., Conticello, S. G., Vaskovsky, A., Levy, Z., Niinobe, M., Yoshikawa, K., Arenas, E. & Fainzilber, M.
J. Biol. Chem. 277: 49101-49104 (2002)Necdin, a postmitotic growth suppressor (Review).
Taniura, H. & Yoshikawa, K.
Recent Research Developments in Neurochemistry 4: 67-79 (2002)
Necdin acts as a transcriptional repressor that interacts with multiple guanosine clusters.
Matsumoto, K., Taniura, H., Uetsuki, T. & Yoshikawa, K.
Gene 272:173-179 (2001)Neurotoxic and neuroprotective effects of glutamate are enhanced by introduction of amyloid precursor protein cDNA.
Tominaga-Yoshino, K., Uetsuki, T., Yoshikawa, K. & Ogura, A.
Brain Res. 918:121-130 (2001)The postmitotic growth suppressor necdin interacts with a calcium binding protein (NEFA) in neuronal cytoplasm .
Taniguchi, N., Taniura, H., Niinobe, N., Takayama, C., Tominaga-Yoshino, K., Ogura, A. & Yoshikawa, K.
J. Biol. Chem. 275: 31674-31681 (2000)Cellular and subcellular localization of necdin in fetal and adult mouse brain.
Niinobe, M., Koyama, K. & Yoshikawa, K.
Dev. Neurosci. 22:310-319 (2000)Characterization and chromosomal mapping of a human necdin pseudogene .
Nakada, Y., Taniura, H., Uetsuki, T. & Yoshikawa, K.
Gene 245:185-191 (2000)Caspase-3 activation and inflammatory responses in rat hippocampus inoculated with a recombinant adenovirus expressing the Alzheimer amyloid precursor protein.
Masumura, M., Hata, R., Nishimura, I., Uetsuki, T., Sawada, T. & Yoshikawa, K.
Mol. Brain Res. 80, 219-227 (2000)Cell cycle regulators in neural stem cells and postmitotic neurons (Review).
Yoshikawa, K.
Neurosci. Res. 37:1-14 (2000)Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein.
Uetsuki, T., Takemoto, K., Nishimura, I., Okamoto, M., Niinobe, M., Momoi, T., Miura, M. & Yoshikawa, K.
J. Neurosci. 19, 6955-6964 (1999)Physical and functional interactions of neuronal growth suppressor necdin with p53.
Taniura, H., Matsumoto, K. & Yoshikawa, K.
J. Biol. Chem., 274, 16242-16248 (1999)Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells.
Azuma-Hara, M., Taniura, H., Uetsuki, T., Niinobe, M. & Yoshikawa, K.
Exp. Cell Res. 251: 442-451(1999)Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.
Taniura, H., Taniguchi, N., Hara, M. & Yoshikawa, K.
J. Biol. Chem., 273:720-728 (1998)The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region.
Nakada, Y., Taniura, H., Uetsuki, T., Inazawa, J. & Yoshikawa,K.
Gene 213, 65-72 (1998)Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer.
Nishimura, I., Uetsuki, T., Dani, S.U., Ohsawa, Y., Saito, I., Okamura, H., Uchiyama, Y. & Yoshikawa, K.
J. Neurosci. 18:2387-2398 (1998)Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons.
Barnes, N.Y., Li, L., Yoshikawa, K., Schwartz, L.M., Oppenheim, R.W. & Milligan, C.E.
J. Neurosci. 18:5869-80 (1998)Glutamate responsiveness enhanced in neurons expressing amyloid precursor protein.
Tominaga, K., Uetsuki, T., Ogura, A. & Yoshikawa, K.
NeuroReport, 8:2067-2072 (1997)Internal disintegration of neurons by amyloid beta protein precursors (Book chapter).
Yoshikawa, K.
In: Principles of Neural Aging (Dani S. U., Hori A. and Walter G. F. eds), pp 115-125. Elsevier, Amsterdam, 1997Structure and expression of the mouse necdin gene: Identification of a postmitotic neuron-restrictive core promoter .
Uetsuki, T., Takagi, K., Sugiura, H. & Yoshikawa, K.
J. Biol. Chem. 271: 918-924 (1996)Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons.
Hayashi, Y., Matsuyama, K., Takagi, K., Sugiura, H. & Yoshikawa, K.
Biochem. Biophys. Res. Commun. 213:317-324 (1995)Determination of a necdin cis-acting element required for neuron specific expression by using zebra fish.
Kuo, C.-H., Uetsuki, T., Kim, C.-H., Tanaka, H., Li, B.-S., Taira, E., Higuchi, H., Okamoto, H., Yoshikawa, K. & Miki, N.
Biochem. Biophys. Res. Commun. 211, 438-446 (1995)Neurotoxicity of amyloid βprotein and the amyloid β-protein precursor (Book chapter).
Yoshikawa, K.
In "Pathobiology of Alzheimer's disease" (eds. Goate, A. & Ashall, F.) pp.145-165, Academic Press London, 1995Alzheimer amyloid protein precursor enhances proliferation of neural stem cells from fetal rat brain.
Hayashi, Y., Kashiwagi, K. & Yoshikawa, K.
Biochem. Biophys. Res. Commun. 205, 936-943 (1994)Neurotoxicity of beta amyloid (Scientific correspondence).
Yoshikawa, K.
Nature 361, 122-123 (1993)The characterization of 'Secretase', Alzheimer amyloid protein secreting enzyme.
Maruyama, K., Usami, M., Harigaya, W., Kametani, F., Tanaka, K. & Yoshikawa, K.
Advances in the Biosciences 87, 313-314 (1993)Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor.
Yoshikawa, K., Aizawa, T. & Hayashi, Y.
Nature 359, 64-67 (1992).Protease inhibitors generate cytotoxic fragments from Alzheimeramyloid protein precursor in cDNA-transfected glioma cells.
Hayashi, Y., Kashiwagi, K. & Yoshikawa, K.
Biochem. Biophys. Res. Commun. 187, 1249-1255 (1992)Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain.
Aizawa, T., Maruyama, K., Kondo, H. & Yoshikawa, K.
Dev. Brain Res. 68, 265-274 (1992)A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells .
Maruyama, K., Usami, M., Aizawa, T. & Yoshikawa, K.
Biochem. Biophys. Res. Commun. 178, 291-296 (1991)A DNA-transfected cell model for Alzheimer amyloidogenesis: Demonstration of primordial amyloid fibrils in COS cells (Book chapter).
Yoshikawa, K., Maruyama, K., Terakado, K., Usami, M. & Aizawa, T.
In "Frontiers of Alzheimer Research" (eds. Ishii T, Allsop D, Selkoe DJ)pp. 217-227 Excerpta Medica, Amsterdam, 1991Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells.
Yoshikawa, K., Aizawa, T. & Maruyama, K.
Biochem. Biophys. Res. Commun. 171, 204-209 (1990).Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor.
Maruyama, K., Terakado, K., Usami, M. & Yoshikawa, K.
Nature 347: 566-569 (1990).
Updated
4/19/12