大阪大学蛋白質研究所
　
Division of Matrixome Research and Application
Institute for Protein Research, Osaka Univ.　　
　Original Papers

2022

Adachi, H., Morizane, A., Torikoshi, S., Raudzus, F., Taniguchi, Y., Miyamoto, S., Sekiguchi, K., Takahashi, J.
Pretreatment with perlecan-conjugated laminin-E8 fragment enhances maturation of grafted dopaminergic progenitors in Parkinson's disease model.
Stem Cells Transl. Med., Jul 20; 11(7): 767-777, 2022
Hayakawa, T., Fujita, F., Okada, F., Sekiguchi, K.
Establishment and characterization of immortalized sweat gland myoepithelial cells.
Sci. Rep., Jan 7; 12(1): 7. doi:10.1038/s41598-021-03991-5., 2022

2021

Sougawa, N., Miyagawa, S., Kawamura, T., Matsuura, R., Harada, A., Sakaim Y., Mochizuki-Oda, N., Sato-Nishiuchi, R., Sekiguchi, K., Sawa, Y.
Combined administration of laminin-221 and prostacyclin agonist enhances endogenous cardiac repair in and acute rat heart.
Sci. Rep., Nov 15; 11(1): 22243. doi:10.1038/s41598-021-00918-y., 2021
Taniguchi, Y., Nagano, C., Sekiguchi, K., Tashiro, A., Sugawara, N., Sakaguchi, H., Umeda, C., Aoto, Y., Ishiko, S., Rossanti, R., Sakakibara, N., Horinouchi, T., Yamamura, T., Kondo, A., Nagai, S., Nagase, H., Miner, J.H., Iijima, K., Nozu, K.
Clear evidence of LAMA5 gene biallelic truncationg variants cause infantile nephrotic syndrome.
Kidney360, Oct 15; 2(12): 1968-1978. doi:10.34067/KID.0004952021., 2021
Arimori, T., Miyazaki, N., Mihara, E., Takizawa, M., Taniguchi, Y., Cabanas, C., Sekiguchi, K., Takagi, J.
Structural mechanism of laminin recognition by integrin.
Nature Commun., Jun 29; 12 (1): doi: 10.1038/s41467-021-24184-8., 2021
Tsutsui, K., Machida, H., Nakagawa, A., Ahn, K., Morita, R., Sekiguchi, K., Miner, J.H., Fujiwara, H.
Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions.
Nat. Commun., May 10; 12 (1): 2557. doi: 10.1038/s41467-021-22881-y., 2021
Kiyozumi, D., Yaguchi, S., Yaguchi, J., Yamazaki, A., Sekiguchi, K.
Human disease-associated extracellular matrix orthologs ECM3 and QBRICK regulate primary mesenchymal cell migration in sea urchin embryos.
Exp. Anim., Apr 6; doi: 10.1538/expanim.21-0001., 2021
Yuzuriha, A., Nakamura, S., Sugimoto, N., Kihara, S., Nakagawa, M., Yamamoto, T., Sekiguchi, K., Eto, K.
Extracellular laminin regulates hepatopoietic potential of pluripotent stem cells through integrin beta1-ILK-beta-catenin-JUN axis.
Stem Cell Res., Mar 16; 53:102287. doi: 10.1016/j.scr.2021.1002287., 2021

2020

Elbitar, S., Renard,M., Arnaud, P., Hanna, N., Jacob, MP., Guo, DC., Tsutsui, K., Gross, MS., Kessler, K., Tosolini, L., Dattilo, V., Dupont, S., Jonquet, J., Langeois, M., Benarroch, L., Aubart, M., Ghaleb, Y., Abou Khalil, Y., Varret, M., El Khoury, P., Ho-Tin-Noe, B., Alembik, Y., Gaertner, S., Isidor, B., Gouya, L., Milleron, O., Sekiguchi, K., Milewicz, D., De Backer, J., Le Goff, C., Michel, JB., Jondeau, G., Sakai, LY., Boileau, C., Abifadel, M.
Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm.
Genet. Med., Aug 28; doi: 10.1038/s41436-020-00947-4, in press
Samura, T., Miyagawa, S., Kawamura, T., Fukushima, S., Yokoyama, JY., Takeda, M., Harada, A., Ohashi, F., Sato-Nishiuchi, R., Toyofuku, T., Toda, K., Sekiguchi, K., Sawa, Y.
Laminin-221 Enhances Therapeutic Effects of Human-Induced Pluripotent Stem Cell-Derived 3-Dimensional Engineered Cardiac Tissue Transplantation in a Rat Ischemic Cardiomyopathy Model.
J. Am. Heart Assoc., Aug 18; 9 (16): e015841, 2020
Shibata, S., Hayashi, R., Kudo, Y., Okubo, T., Imaizumi, T., Katayama, T., Ishikawa, Y., Kobayashi, Y., Toga, J., Taniguchi, Y., Honma, Y., Sekiguchi, K., Nishida, K.
Cell-Type Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium.
Stem Cell Reports, Apr 14; 14 (4): 663-676, 2020
Chanthra, N., Abe, T., Miyamoto, M., Sekiguchi, K., Kwon, C., Hanazono, Y., Uosaki, H.
A Novel Fluorescent Reporter System Identifies Laminin-511/521 as Potent Regulators of Cardiomyocyte Maturation.
Sci. Rep., Mar 6; 10 (1): 4249, 2020
Kiyozumi, D., Nakano, I., Sato-Nishiuchi, R., Tanaka, S., Sekiguchi, K.
Laminin is the ECM niche for trophoblast stem cells.
Life Sci. Alliance, Jan 14; 3 (2). pii: e201900515., 2020
Taniguchi, Y., Takizawa, M., Li, S., Sekiguchi, K.
Biparate mechanism for laminin-integrin interactions: Identification of the integrin-binding site in LG domains of the laminin alpha chain.
Matrix Biol., May; 87: 66-76, 2020

2019

Futaki, S., Nakano, I., Kawasaki, M., Sanzen, N., Sekiguchi, K.
Molecular profiling of the basement membrane of pluripotent epiblast cells in post-implantation stage mouse embryos.
Regenerative Therapy, May 10; 12: 55-65, 2019
Suzuki, N., Hyodo, M., Hayashi, C., Mabuchi, Y., Sekimoto, K., Onchi, C., Sekiguchi, K., Akazawa, C.
Laminin alpha2, alpha4, and alpha5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precurseor Cells.
Sci. Rep., Dec 27; 9 (1): 19882., 2019
Kamitani, T., Murota, H., Arase, N., Wataya-Kaneda, M., Sato-Nishiuchi, R., Sekiguchi, K., Okuzaki, D., Motooka, D., Katayama, I.
Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen's disease.
J. Dermatol. Sci., Nov; 96 (2): 73-80, 2019
Sougawa, N., Miyagawa, S., Fukushima, S., Yokoyama, J., Kitahara, M., Harada, A., Mochizuki-Oda, N., Sato-Nishiuchi, R., Sekiguchi, K., Sawa, Y.
Laminin-511 Supplementation Enhances Stem Cell Localization with Suppression in the Decline of Cardiac Function in Acute Intarct Rats.
Transplantation, May; 103 (5): e119-e127. doi: 10.1097/TP.0000000000002653., 2019
Sato, Y., Kiyozumi, D., Futaki, S., Nakano, I., Shimono, C., Kaneko, N., Ikawa, M., Okabe, M., Sawamoto, K., Sekiguchi, K.
Ventricular-subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche.
Mol. Biol. Cell, Jan 1; 30 (1): 56-68, 2019 
 

2018

Shibata, S., Hayashi, R., Okubo, T., Kudo, Y., Katayama, T., Ishikawa, Y., Toga, J., Yagi, E., Honma, Y., Quantock, A.J., Sekiguchi, K., Nishida, K.
Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages.
Cell Rep., Nov 6; 25(6): 1668-1679.e5. doi: 10.1016/j.celrep. 2018.10.032., 2018
Kiyozumi, D., Taniguchi, Y., Nakano, I., Toga, J., Yagi, E., Hasuwa, H, Ikawa, M., Sekiguchi, K.
Laminin gamma1 C-terminal Glu to Gln mutation induces early postimplantation lethality.
Life Sci. Alliance, Sep 10, 1 (5): e201800064, 2018
Shiokawa, M., Kodama, Y., Sekiguchi, K., Kuwada, T., Tomono, T., Kuriyama, K., Yamazaki, H., Morita, T., Marui, S., Sogabe, Y., Kakiuchi, N., Matsumori, T., Mima, A., Nishikawa, Y., Ueda, T., Tsuda, M., Yamauchi, Y., Sakuma, Y., Maruno, T., Uza, N., Tsuruyama, T., Mimori, T., Seno, H., Chiba, T.
Laminin 511 is a target antigen in autoimmune pancreatitis.
Sci. Transl. Med., Aug 8, 10 (453), pii:eaaq0997, doi: 10.1126/scitranslmed.aaq0997., 2018
Fujisaki, H., Futaki, S., Yamada, M., Sekiguchi, K., Hayashi, T., Ikejima, T., Hattori S.
Respective optimal calcium concentrations for proliferation on type I collagen fibrils in two keratinocyte line cells, HaCaT and FEPE1L-8.
Regenerative Therapy, Jun, 8, 73-79, 2018
Takayama, K., Hagihara, Y., Toba, Y., Sekiguchi, K., Sakurai, F., Mizuguchi, H.
Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.
Biomaterials, Apr, 161, 24-32, doi: 10.1016/j.biomaterials.2018.01.019., 2018
Yoshida, S., Hasegawa, T., Suzuki, M., Sugeno, N., Kobayashi, J., Ueyama, M., Fukuda, M., Ido-Fujibayashi, A., Sekiguchi, K., Ezura, M., Kikuchi, A., Baba, A., Takeda, A., Mochizuki, H., Nagai, Y., Aoki, M.
Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.
Hum. Mol. Genet., Mar 1, 27 (5), 823-836, doi: 10.1093/hmg/ddy003., 2018
Ishii, K., Sakurai, H., Suzuki, N., Mabuchi, Y., Sekiya, I., Sekiguchi, K., Akazawa, C.
Recepitulation of Extracellular LAMININ Environment Maintains Stemness of Satelite Cells In Vitro.
Stem Cell Reports, Feb 13, 10 (2), 568-582, doi: 10.1016/j.stemcr.2017.12.013, 2018
Sato-Nishiuchi, R., Li, S., Ebisu, F., Sekiguchi, K.
Recombinant laminin fragments endowed with collagen-binding activity: A tool for conferring laminin-like cell-adhesive activity to collagen matrices.
Matrix Biol., Jan, 65, 75-90, doi: 10.1016/j.matbio.2017.08.001, 2018

2017

Takayama, K., Akita, N., Mimura, N., Akahira, R., Taniguchi, Y., Ikeda, M., Sakurai, F., Ohara, O., Morio, T., Sekiguchi, K., Mizuguchi, H.
Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.
Hepatology Communications, Oct 12, Vol: 1, 1058-1069, 2017
Takizawa, M., Arimori, T., Taniguchi, Y., Kitago, Y., Yamashita, E., Takagi, J., Sekiguchi, K.
Mechanistic basis for the recognition of laminin-511 by alpha6beta1 integrin.
Science Advances, Sep 1, E1701497, 2017
Kurata, R., Futaki, S., Nakano, I., Fujita, F., Tanemura, A., Murota, H., Katayama, I., Okada, F., Sekiguchi, K.
Three-dimentional cell shapes and arrangements in human sweat glands as revealed by whole-mount immunostaining.
PLoS One, Jun 21, 12(6): e0178709. doi: 10.1371/journal.pone.0178709. eCollection, 2017
Taniguchi, Y., Li, S., Takizawa, M., Oonishi, E., Toga, J., Yagi, E., Sekiguchi, K.
Probing the acidic residue within the integrin binding site of laminin-511 that interacts with the metal ion-dependent adhesion site of alpha6beta1 integrin.
Biochem. Biophys. Res. Commun., Jun 3, 487(3): 525-531, 2017
Hayashi, R., Ishikawa, Y., Katori, R., Sasamoto, Y., Taniwaki, Y., Takayanagi, H., Tsujikawa, M., Sekiguchi, K., Quantock, A.J., Nishida, K.
Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells.
Nat. Protoc., Apr;12(4) 683-696, 2017
Morooka, N., Futaki, S., Sato-Nishiuchi, R., Nishino, M., Totani, Y., Shimono, C., Nakano, I., Nakajima, H., Mochizuki, N., Sekiguchi, K.
Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.
Circ. Res., Apr 14, 120 (8):1276-1288, 2017
Karpanen, T., Padberg, Y., van de Pavert, S.A., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., Schulte-Merker, S.
An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation.
Circ. Res., Apr 14, 120 (8):1263-1275, 2017
Fujioka, T., Kaneko, N., Ajioka, I., Nakaguchi, K., Omata, T., Ohba, H., Fassler, R., Garcia-Verdugo, J.M., Sekiguchi, K., Matsukawa, N., Sawamoto, K.
Beta1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain.
EBioMedicine, Feb; 16: 195-203, 2017

2016

Ohta, A.,  Niwa, A., Taniguchi, Y., Suzuki, N.M., Toga, J., Yagi, E., Saiki, N., Nishinaka-Arai, Y., Okada, C., Watanabe, A., Nakahata, T., Sekiguchi, K., Saito, M.K.
Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.
Sci. Rep., Nov 2; 6:35680. doi:10.1038/srep35680., 2016
Qiao, Y.,  Tam, J.K., Tan, S.S., Tai, Y.K., Chin, C.Y., Stewart, A.G., Ashman, L., Sekiguchi, K., Langenbach, S.Y., Stelmack, G., Halayko, A.J., Tran, T.
CD151, a laminin receptor showing increased expression in athsmatic patients, contributes to airway hyperresponsiveness through calcium signaling.
J. Allergy Clin. Immunol., Apr 27; pii:S0091-6749(16)30164-6. doi:10.1016/j.jaci.2016.03.029, 2016
Takayama, K., Mitani, S., Nagamoto, Y., Sakurai, F., Tachibana, M., Taniguchi, Y., Sekiguchi, K., Mizuguchi, H.
Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells.
Biochem. Biophys. Res. Commun., May 20; 474 (1) : 91-96, 2016
Ozawa, A., Sato, Y., Imabayashi, T., Uemura, T., Takagi, J., Sekiguchi, K.
Molecular Basis of the Ligand-binding Specificity of alphavbeta8 Integrin.
J. Biol. Chem., May 27; 291 (22) : 11551-11565, 2016
Hayashi, R., Ishikawa, Y., Sasamoto, Y., Katori, R., Nomura, N., Ichikawa, T., Araki, S., Soma, T., Kawasaki, S., Sekiguchi, K., Quantock, A.J., Tsujikawa, M., Nishida, K.
Co-ordinated ocular development from human iPS cells and recovery of corneal function.
Nature, Mar 17; 531: 376-380, 2016

2015

 Yamada, M., Sekiguchi, K.
Molecular Basis of Laminin-Integrin Interactions.
Curr. Top Membr, 76: 197-229, 2015 
 Sasaki, K., Yokobayashi, S., Nakamura, T., Okamoto, I., Yabuta, Y., Kurimoto, K., Ohta, H., Moritoki, Y., Iwatani, C., Tsuchiya, H., Nakamura, S., Sekiguchi, K., Sakuma, T., Yamamoto, T., Mori, T., Woltjen, K., Nakagawa, M., Yamamoto, T., Takahashi, K., Yamanaka, S., Saitou, M.
Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
Cell Stem Cell, 17(2): 178-194, 2015
 Nakamura, T., Yabuta, Y., Okamoto, I., Aramaki, S., Yokobayashi, S., Kurimoto, K., Sekiguchi, K., Nakagawa, M., Yamamoto, T., and Saitou, M.
SC3-seq: a method for highly parallel and quintitative measurement of single-cell gene expression.
Nucleic Acids Res., 43(9): e60. doi: 10.1093/nar/gkv134, 2015
Li, X., Qian, H., Takizawa, M., Koga, H., Tsuchisaka, A., Ishii, N., Hayakawa, T., Ohara, K., Shitaru, C., Zillikens, D., Sekiguchi, K., and Hashimoto, T.
N-linked glycosylation on laminin gamma1 influences recognition of anti-laminin gamma1 pemphigoid autoantibodies.
J. Dermatol. Sci., 77(2): 125-129, 2015
Shinde, A.V., Kelsh, R., Peters, J.H., Sekiguchi, K., Van De Water, L., and McKewon-Longo, P.J.
The alpha4beta1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts.
Matrix Biol., 41: 26-35, 2015

2014

 Kiyozumi, D., Sato-Nishiuchi, R., and Sekiguchi, K.
In situ detection of integrin ligands.
Curr. Protoc. Cell Biol., 65:10.19.1-10.19.17, 2014
 Kurata, R., Futaki, S., Nakano, I., Tanemura, A., Murota, H., Katayama, I., and Sekiguchi, K.
Isolation and characterization of sweat gland myoepithelial cells from human skin.
Cell Struct. Funct., 39:101-112, 2014
 Yoshino, T., Saito, D., Atsuta, Y., Uchiyama, C., Ueda, S., Sekiguchi, K., and Takahashi, Y.
Interepithelial signaling with nephric duct is required for the formation of overlying coelomic epithelial cell sheet.
Proc. Natl. Acad. Sci. USA., 111:6660-6665, 2014.
Doi, D., Samata, B., Katsukawa, M., Kikuchi, T., Morizane, A., Ono, Y., Sekiguchi, K., Nakagawa, M., Parmar, M., Takahashi, J.
Isolation of human induced pluripotent stem cell-derived dopaminergic progenitors by cell sorting for successful transplantation.
Stem Cell Reports,　Mar 6; 2(3): 337-350, 2014
Nakagawa, M., Taniguchi, Y., Senda, S., Takizawa, N., Ichikawa, T., Asano, K., Morizane, A., Doi, D., Takahashi, J., Nishizawa, M., Yoshida, Y., Toyoda, T., Osafune, K., Sekiguchi, K., and Yamanaka, S.
A novel efficietnt feeder-free culture system for the derivation of human induced pluripotent stem cells.
Scientific Reports,　Jan 8; 4: 3594, 2014

2013

Yamada, M., and Sekiguchi, K.
Disease-associated single amino acid mutation in the calf-1 domain of integrin alpha3 leads to defects in its processing and cell surface expression.
Biochem. Biophys. Res. Commun., 441: 988-993, 2013
Jeoug, SJ., Luo, R., Singer, K., Giera, S., Kreidberg, J., Kiyozumi, D., Shimono, C., Sekiguchi, K., and Piao, X.
GPR56 functions together with akoha3beta1 integrin in regulating cerebral cortical development.
PLos One., 8: e68781. doi: 10.1371/journal.pone.0068781, 2013
Yamada, M., Mugnai, G., Serada, S., Yagi, Y., and Sekiguchi, K.
Substrate-attached materials are enriched with tetraspanins and are analogous to the structures associated with rear-end retraction in migrating cells.
Cell Adh. Migr., 7: 304-314, 2013
Inagaki, F. F., Tanaka, M., Inagaki, N. F., Yagai, T., Sato, Y., Sekiguchi, K., Oyaizu, N., Kokudo, N., and Miyajima, A.
Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells.
Biochem. Biophys. Res. Commun., 430:751-756, 2013.
Sato, Y., Shimono, C., Li, S., Nakano, I., Norioka, N., Sugiura, N., Kimata, K., Yamada, M., and Sekiguchi, K.
Nephronectin binds to heparan sulfate proteoglycans via its MAM domain.
Matrix Biol., 32: 188-195, 2013.
Song, X., Sato, Y., Sekiguchi, K. Tanaka, H., and Ohta, K.
Equarin is involved in cell adhesion via heparan sulfate proteoglycan during lens development.
Dev. Dyn., 242:23-29, 2013.
Sotiropoulou, P. A., Karambelas, A. E., Debaugnies, M., Candi, A., Bouwman, P., Moers, V., Rocha, A. S., Sekiguchi, K., Jonkers, J. and Blanpain, C.
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Genes Dev., 27:39-51, 2013

2012

Miyazaki, T., Futaki, S., Suemori, H., Taniguchi, Y., Yamada, M., Kawasaki, M., Hayashi, M., Kumagai, H., Nakatsuji, N., Sekiguchi, K., and Kawase, E.
Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells.
Nature Commun. 3:1236. doi: 10.1038/ncomms223, 2012.
Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, and Sasai Y.
Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture.
PLoS One. 7:e53024. doi: 10.1371/journal.pone.0053024, 2012.
McKee, K. K., Yang, D. H., Patel, R., Chen, Z. L., Strickland, S., Takagi, J., Sekiguchi, K., and Yurchenco, P. D.
Schwann cell myelination requires integration of laminin activities.
J. Cell Sci.,125: 4609-4619, 2012.
Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., and Sasai, Y.
Self-formation of optic cups and storable stratified neural retina from human ESCs.
Cell Stem Cell, 10:771-785, 2012.
Kiyozumi, D., Takeichi, M., Nakano, I., Sato, Y., Fukuda, T., and Sekiguchi, K.
Basement membrane assembly of the integrin a8b1 ligand nephronectin requires Fraser syndrome-associated proteins.
J. Cell Biol., 197:677-689, 2012.
Fujita, M., Ieguchi, K., Davari, P., Yamaji, S., Taniguchi, Y., Sekiguchi, K., Takada, Y. K., and Takada, Y.
Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.
J. Biol. Chem., 287:12491-12500, 2012.
Sengle, G., Tsutsui, K., Keene, D. R., Tufa, S. F., Carlson, E. J., Charbonneau, N. L., Ono, R. N., Sasaki, T., Wirtz, M. K., Samples, J. R., Fessler, L. I., Fessler. J. H., Sekiguchi, K., Hayflick, S. J., and Sakai, L. Y.
Microenvironmental regulation by fibrillin-1.
PLoS Genet., e1002425, 2012.
Song, X., Sato, Y., Felemban, A., Ito, A., Hossain, M., Ochiai, H., Yamamoto, T., Sekiguchi, K. Tanaka, H., and Ohta, K.
Equarin is involved as an FGF signaling modulator in chick lens differentiation.
Dev. Biol., 368:109-117, 2012.
Sato-Nishiuchi, R., Nakano, I., Ozawa, A., Sato, Y., Takeichi, M., Kiyozumi, D., Yamazaki, K., Yasunaga, T., Futaki, S. and Sekiguchi, K.
Polydom/SVEP1 is a ligand for integrin a9b1.
J. Biol. Chem., 287:25615-25630, 2012.

2011

Fusaoka-Nishioka, E., Shimono, C., Taniguchi, Y., Togawa, A., Yamada, A., Inoue, E., Onodera, H., Sekiguchi, K., and Imai, T.
Differential effects of laminin isoforms on axon and dendrite development in hippocampal neurons.
Neurosci. Res., 71:421-426, 2011.
Saito, M., Kurokawa, M., Oda, M., Oshima, M., Tsutsui, K., Kosaka, K., Nakao, K., Ogawa, M., Manabe, R., Suda, N., Ganjargal, G., Hada, Y., Noguchi, T., Teranaka, T., Sekiguchi, K., Yoneda, T., and Tsuji, T.
ADAMTSL6b rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.
J. Biol. Chem., 286:38602-38613, 2011.
Vissers, L. E. L. M., Cox, T. C., Maga, M., Short, K., Wiradjaja, F., Janssen I. M., Jehee, F., Bertola, D., Liu, J., Yagnik, G., Sekiguchi, K., Kiyozumi, D., van Bokhoven H., Marcelis, C., Cunningham, M. L., Anderson, P. J., Boyadjiev, S., Passos-Bueno, M. R., Veltman, J. A., Smyth, I., Buckley, M. F., and Roscioli, T.
Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
PLos Genet., e1002278, 2011.
Kiyozumi, D., Nakano, I., Takahashi, K. L., Hojo, H., Aoyama, H., and Sekiguchi, K.
Fused pulmonary lobes is a rat model of human Fraser syndrome.
Biochem. Biophys. Res. Commun., 411:440-444, 2011.
Goyal, A., Pal, N., Concannon, M., Paul, M., Doran, M., Poluzzi, C., Sekiguchi, K., Whitelock, J. M., Neill, T., and Iozzo, R. V.
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
J. Biol. Chem., 286:25947-25962, 2011.
Kiyozumi, D., Osada, A., Sugimoto N., Weber, C. N., Ono, Y., Imai, T., Okada, A., and Sekiguchi, K.
Identification of genes expressed during hair follicle induction.
J. Dermatol., 38:674-679, 2011.
Xhabija, B., Taylor, G. S., Fujibayashi, A., Sekiguchi, K., and Vacratsis, P. O.
Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2.
FEBS Lett., 585:1722-1728, 2011.
Mori, T., Kariya, Y., Komiya, E., Higashi, S., Miyagi, Y., Sekiguchi, K., and Miyazaki, K.
Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers.
Cancer Sci., 102:1095-1100, 2011.
Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T., and Sasai, Y.
Self-organizing optic-cup morphogenesis in three-dimensional culture.
Nature, 472:51-56, 2011.
Fujiwara, H., Ferreira, M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L. F., and Watt, F. M.
The basement membrane of hair follicle stem cells is a muscle cell niche.
Cell, 144:577-589, 2011.

2010

Li, S., Shimono, C., Norioka, N., Nakano, I., Okubo, T., Yagi, Y., Hayashi, M., Sato, Y., Fujisaki H., Hattori, S., Sugiura, N., Kimata, K., and Sekiguchi, K.
Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate-binding activity.
J. Biol. Chem., 285:36645-36655, 2010.
Ieguchi, K., Fujita, M., Ma, Z., Davari, P., Taniguchi, Y., Sekiguchi, K., Wang, B., Takada, Y., and Takada, Y.
Direct binding of the EGF-like domain of neuregulin-1 to integrins avb3 and a6b4 is involved in neuregulin-1/ErbB signaling.
J. Biol. Chem., 285:31388-31398, 2010.
Uchiyama, Y., Sakaguchi, M., Terabayashi, T., Inenaga, T., Inoue, S., Kobayashi, C., Oshima, N., Kiyonari, H., Nakagata, N., Sato, Y., Sekiguchi, K., Miki, H., Fujimura, S., Tanaka, S., and Nishinakamura, R.
Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme.
Proc. Natl. Acad. Sci. USA., 107:9240-9245, 2010.
Carney, T. J., Feitosa, N. M., Sonntag, C., Slanche, K., Kluger, J., Kiyozumi, D., Gebauer, J., Talbot, J. C., Kimmel, C. B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P. W., and Hammerschmidt, M.
Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser syndrome disease genes.
PloS Genetics, 15, e1000907, 2010.
Shimono, C., Manabe, R., Yamada, T., Fukuda, S., Kawai, J., Furutani, Y., Tsutsui, K., Ikenaka, K., Hayashizaki, Y., and Sekiguchi, K.
Identification and characterization of nCLP2, a novel Clq family protein expressed in the central nervous system.
J. Biochem., 151:565-579, 2010.
Miura, S., Mitsui, K., Heishi, T., Shukunami, C., Sekiguchi, K., Kondo, J., Sato, Y., and Hiraki, Y.
Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor.
Exp. Cell Res., 316:775-788, 2010.
Tsutsui, K., Manabe, R., Yamada, T., Nakano, I., Oguri, Y., Keene, D. R., Sengle G., Sakai, L. Y., and Sekiguchi, K.
ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation.
J. Biol. Chem., 285:4870-4882, 2010.

2009

Vuoristo, S., Virtanen, I., Takkunen, M., Palgi, J., Kikkawa, Y., Rousselle, P., Sekiguchi, K., Tuuri, T., and Otonkoski, T.
Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support.
J. Cell Mol. Med., 13:2622-2633, 2009.
Sato, Y., Uemura, T., Morimitsu, K., Sato-Nishiuchi, R., Manabe, R., Takagi, J., Yamada, M., and Sekiguchi, K.
Molecular basis of the recognition of nephronectin by integrin a8b1.
J. Biol. Chem., 284:14524-14536, 2009.
Taniguchi, Y., Ido, H., Sanzen, N., Hayashi, M., Sato-Nishiuchi, R., Futaki, S., and Sekiguchi, K.
The C-terminal region of laminin b chains modulates the integrin binding affinities of laminins.
J. Biol. Chem., 284:7820-7831, 2009.
Dainichi, T., Kurono, S., Ohyama, B., Ishii, N., Sanzen, N., Hayashi, M., Shimono, C., Taniguchi, Y., Koga, H., Karashima, T., Yasumoto, S., Zillikens, D., Sekiguchi, K., and Hashimoto, T.
Anti-laminin gamma-1 pemphigoid.
Proc. Natl. Acad. Sci. USA., 106:2800-2805, 2009.
Katayama, M., Ishizaka, A., Sakamoto, M., Fujishima, S., Sekiguchi, K., Asano, K., Betsuyaku, T., Kotani, T., Ware, L. B., Matthay, M. A., Hashimoto, S.
Laminin g2 fragments are increased in the circulation of patients with early phase acute lung injury.
Intensive Care Med., 36:479-486, 2009.

2008

Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K.
Transcriptome-based systematic identification of extracellular matrix proteins.
Proc. Natl. Acad. Sci. USA, in press.
Ido H, Ito S, Taniguchi Y, Hayashi M, Sato-Nishiuchi R, Sanzen N, Hayashi Y, Futaki S, Sekiguchi K.
Laminin isoforms containing the gamma 3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the carboxyl-terminal regions of the gamma 1 and gamma 2 chains.
J. Biol. Chem., in press.
Gao J, DeRouen MC, Chen CH, Nguyen M, Nguyen NT, Ido H, Harada K, Sekiguchi K, Morgan BA, Miner JH, Oro AE, Marinkovich MP.
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.
Genes Dev. 22:2111-2124, 2008.
Miyazaki T, Futaki S, Hasegawa K, Kawasaki M, Sanzen N, Hayashi M, Kawase E, Sekiguchi K, Nakatsuji N, Suemori H.
Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells.
Biochem. Biophys. Res. Commun. 375:27-35, 2008.
Yamada M, Tamura Y, Sanzen N, Sato-Nishiuchi R, Hasegawa H, Ashman LK, Rubinstein E, Yáñez-Mó M, Sánchez-Madrid F, Sekiguchi K.
Probing the interaction of tetraspanin CD151 with integrin alpha3beta1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha3beta1 complex.
Biochem. J., 415:417-427, 2008.
Kariya, Y., Kato, R., Itoh, S., Fukuda, T., Shibukawa, Y., Sanzen, N., Sekiguchi, K., Wada, Y., Kawasaki, N., and Gu, J.　　
N-Glycosylation of Laminin-332 regulates its biological functions: a novel function of the bisecting GlcNAc.
J. Biol. Chem., 283:33036-33045, 2008.
Yamada M, Sumida Y, Fujibayashi A, Fukaguchi K, Sanzen N, Nishiuchi R, Sekiguchi K.
The tetraspanin CD151 regulates cell morphology and intracellular signaling on laminin-511.
FEBS J. 275:3335-3351, 2008.
Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, Kikkawa Y, Sekiguchi K, Hukkanen M, Konttinen YT, Otonkoski T.
Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia51: 1181-1191, 2008.
Takashima S, Yasuo M, Sanzen N, Sekiguchi K, Okabe M, Yoshida T, Toda A, Nikaido T.
Characterization of laminin isoforms in human amnion.
Tissue Cell 40:75-81, 2008.
Torikai K, Otsuka Y, Nishimura M, Sumida M, Kawai T, Sekiguchi K, Ueda I.
Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes.
Bioorg Med Chem. 16:5441-51, 2008.
Fujibayashi A, Taguchi T, Misaki R, Ohtani M, Dohmae N, Takio K, Yamada M, Gu J, Yamakami M, Fukuda M, Waguri S, Uchiyama Y, Yoshimori T, Sekiguchi K.
Human RME-8 is involved in membrane trafficking through early endosomes.
Cell Struct Funct. 33:35-50, 2008.

2007

Ido, H., Nakamura, A., Kobayashi, R., Ito, S., Li, S., Futaki, S., and Sekiguchi, K.

The requirement of the glutamic acid residue at the third position from the carboxyl termini of the laminin γ chains in integrin binding by laminins. J. Biol. Chem., 282:11144-11154, 2007.
Kiyozumi, D., Sugimoto, N., Nakano, I., and Sekiguchi, K.

Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue destribution patterns distinct from those of Fras 1, Frem2, and QBRICK/Frem1. Matrix Biol., 26: 456-462, 2007.

Fujiwara, H., Hayashi, Y., Sanzen, N., Weber, C. N., Emoto, T., Futaki, S., Niwa, H., Murray, P., Edgar, D., and Sekiguchi, K.

Regulation of mesodermal differentiation of mouse embryonic stem cells by basement membranes. J. Biol. Chem., 282:29701-29711, 2007.
Jaana Willberg, Marketta Hormia, Minna Takunen, Yamato Kikkawa, Kiyotoshi Sekiguchi and Virtanen, I.

Lutheran blood group antigen as receptor for alpha5-laminins in gingival epithelia.  J. Periodontol., 78:1810-1818, 2007.
2006
Nishiuchi, R., Takagi, J., Hayashi, M., Ido, H., Yagi, Y., Sanzen, N., Tsuji, T., Yamada, M., and Sekiguchi, K.
Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant [alpha]3[beta]1, [alpha]6[beta]1, [alpha]7[beta]1 and [alpha]6[beta]4 integrins. Matrix Biol., 25:189-197, 2006.
Ido, H., Harada, K., Yagi, Y., and Sekiguchi, K.
Probing the integrin-binding site within the globular domain of laminin-511 with the function-blocking monoclonal antibody 4C7. Matrix Biol., 25:112-117, 2006.
Hayashi, Y., Weber, C.N., Emoto, T., Fujiwara, H., Sanzen, N., Futaki, S., and Sekiguchi, K.
A novel large-scale production system for modified basement membrane matrices using gene-swapped parietal endoderm cells. Matrix Biol., 25:85-88, 2006.
Kiyozumi, D., Sugimoto, N., and Sekiguchi, K.

Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.  Proc. Natl. Acad. Sci. USA, 103:11981-11986, 2006.
Irving-Rogers, H.F., Friden, B.E., Mason, H.D., Brannstrom, M., Sekiguchi, K., Sanzen, N., Sorokin, L.M., Sado, Y., Ninomiya, Y., and Rodgers, R.J.
Extracellular matrix of the human cyclic corpus luteum.  Mol. Human Reproduct., 12:525-534, 2006.
McDearmon, E. L., Combs, A. C., Sekiguchi, K., Fujiwara, H., and Ervasti, J.
Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11.  FEBS lett., 580:3381-3385, 2006
Namba, F., Kitajima, H., Tabata, A., Nakayama, M., Suehara, N., Matsunami, K., Yanagihara, K., Nishihara, M., Morita, A., Yamada, M., Kimoto, A., Hirano, S., Sekiguchi, K., Fujimura, M., Whitsett, J. A., and Yanagihara, I.
Anti-annexin A2 antibody in preterm infants: its association with chorioammnionitis.  Pediatric Res., 60:699-704, 2006.
Niimi, T., Hayashi, Y., Sekiguchi, K., and Kitagawa, Y.

The Sp family of transcription factors regulates the human laminin alpha1 gene in JAR choriocarcinoma cells.Biochim. Biophys. Acta, 1759:573-579, 2006.
2005
Nagato, S., Nakagawa, K., Harada, H., Kohno, S., Fujiwara, H., Sekiguchi, K., Ohue, S., Iwata, S., and Ohnishi, T.
Downregulation of laminin[alpha]4-chain expression inhibits glioma invasion in vitro and in vivo. Int. J. Cancer, 117, 41-50, 2005.
Bair, B. L., Chen, M. L., McDaniel, K., Sekiguchi, K., Cress, A. E., Nagle, R. B., and Bowden, G. T.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration. Neoplasia, 7, 380-389, 2005.
Aumailley, M., Bruckner-Tuerman, L., Carter, W. G., deutzumann, R., Edgar, D., Ekblom, P., Engel, J., Engvall, E., Hohenester, E., Jones, J. C. R., Kleinmann, H. K., Marinkovich, M. P., Martin, G. R., Mayer, U., Megeguzzi, G., Miner, J. H., Miyazaki, K., Patarroyo, M., Paulsson, M., Quaranta, V., Sasaki, T., Sekiguchi, K., Sorokin, L. M., Talts, J. F., Tryggvason, K., Uitto, J., Virtanen, I., von der Mark, K., Wewer, U. M., Yamada, Y., and Yurchenko, P. D.
A simplified laminin nomenclature. Matrix Biol., 24, 326-332, 2005.
Furutani, Y., Manabe, R., Tsutsui, K., Yamada, T., Sugimoto, N., Fukuda, S., Kawai, J., Sugiura, N., Kimata, K., Hayashizaki, Y., Sekiguchi, K.
Identification and characterization of photomedins, novel olfactomedin domain-containing proteins with chondroitin sulfate-E binding activity. Biochem. J., 389, 675-684, 2005.
Iwasaki, K., Mitsuoka, K., Fujiyoshi, Y., Fujisawa, Y., Kikuchi, M., Sekiguchi, K., and Yamada, T.
Electron tomography reveals deiverse conformations of integrin [alpha]IIb[beta]3 in the active state. J. Struct. Biol., 150, 259-267, 2005.
Fujita, M., Khazenzon, N. M., Bose, S., Sekiguchi, K., Sasaki, T., Carter, W. G., Ljubimov, A. V., Black, K. L., and Ljubimova, J. Y.
Overexpression of [beta]1 chain-containing laminins in capillary basement membranes of human breast cancer and its metastasis. Breast Cancer Res., 7, R411-421, 2005.
Kiyozumi, D., Osada, A., Sugimoto, N., Weber, C. N., Ono, Y., Imai, T., Okada, A., and Sekiguchi, K.
Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp. Cell Res., 306, 9-23, 2005
Nishiuchi, R., Sanzen, N., Nada, S., Sumida, Y.,, Wada, Y., Takagi, J., Okada, M., Hasegawa, H., and Sekiguchi, K.
Potentiation of the ligand-binding activity of integrin a3b1 via association with tetraspanin CD151. Proc. Natl. Acad. Sci. USA., 102,1939-1944, 2005.
Katayama, M., Funakoshi, A., Sumii, T., Sanzen, N., and Sekiguchi, K.
Laminin [gamma]2-chain fragment circulating level increases in patients with metastatic pancreatic ductal cell adenocarcinomas. Cancer lett., 225, 167-176.
Osada, A., Kiyozumi, D., Tsutsui, K., Ono, Y., Weber, C. N., Sugimoto, N., Imai, T., Okada, A., and Sekiguchi, K.
Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis. Exp. Cell Res., 303,148-159, 2005.
2004
Futaki, S., Hayashi, Y., Emoto, T., Weber, C. N., and Sekiguchi, K.
Sox7 plays crucial roles in parietal endoderm differentiation of F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression. Mol. Cell Biol., 24, 10492-10503, 2004.
Astrof, S., Crowley, D., George, E. L., Fukuda, T., Sekiguchi, K., Hanahan, D., and Hynes, R. O.
Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Mol. Cell Biol., 24, 8662-8670, 2004.
Kikkawa, Y., Talts, J. F., Genersch, E., Sanzen, N., Sekiguchi, K., Fassler, R., Campbell, K. P., and Ekblom, P.
Laminin isoforms differentially regulate cell adhesion, spreading, proliferation and ERK activation of [beta]1-null cells. Exp. Cell Res., 300, 94-108, 2004.
Niimi, T., Hayashi, Y., Futaki, S., and Sekiguchi, K.
Sox7 and Sox17 regulate the parietal endoderm-specific enhancer activity of mouse laminin [alpha]1 gene. J. Biol. Chem., 278, 38055-38061, 2004.
Ljubimova, J. Y., Fugita, M., Khazenzon, N. M., Das, A., Pikul, B. B., Newman, D., Sekiguchi, K., Sorokin, L. M., Sasaki, T., and Black, K. L.
Laminin-8 association with glial tumor grade, recurrence and patient survival. Cancer, 101, 604-612, 2004.
Saito, J., Morishige, N., Chikama, T., Gu, J., Sekiguchi, K., and Nishida, T.
Differential regulations of phosphorylation of focal adhesion kinase and paxillin by the small GTP-binding protein Rho in human corneal epithelial cells. Jpn. J. Ophthalmol., 48, 199-207, 2004.
Katayama, M., and Sekiguchi, K.
Laminin-5 in epithelial tumor invasion. J. Mol. Histol., 35, 277-286, 2004.
Isaji, T., Gu, J., Nishiuchi, R., Zhao, Y., Takahashi, M., Miyoshi, E., Konke, K., Sekiguchi, K., and Taniguchi, N.
Introduction of bisecting GlcNAc into integrin [alpha]5[beta]1 reduces ligand binding and down-regulates cell adhesion and cell mibration. J. Biol. Chem., 279, 19747-19754, 2004.
Hayashi, Y., Emoto, T., Futaki, S., and Sekiguchi, K.
Establishment and characterization of a parietal-endoderm like cell line derived from Engelbreth-Holm-Swarm tumor (EHSPEL), a possible resource for an engineered basement membrane matrix. Matrix Biol., 23, 47-62, 2004.
Ido, H., Harada, K., Futaki, S., Hayashi, Y., Nishiuchi, R., Natsuka, Y., Li, S., Wada, Y., Combs, A. C., Ervasti, J. M., and Sekiguchi, K.
Molecular dissection of the [alpha]-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10. J. Biol. Chem., 279, 10946-10954, 2004.
Fujiwara, H., Gu, J., and Sekiguchi, K.
Rac regulates integrin-mediated endothelial cell adhesion and migration on laminin-8. Exp. Cell Res., 292, 67-77, 2004.
2003
Futaki, S., Hayashi, Y., Yamashita, M., Yagi, K., Bono, H., Hayashizaki, Y., Okazaki, Y., and Sekiguchi, K.
Molecular basis of constitutive production of basement membrane components: gene expression profiles of Engelbreth-Holm-Swarm tumor and F9 embryonal carcinoma cells. J. Biol. Chem., 278, 50691-50701, 2003.
Kozaki, T., Matui, Y., Gu, J., Nishiuchi, R., Sugiura, N., Kimata, K., Ozono, K., Yoshikawa, H., and Sekiguchi, K.
Recombinant expression and characterization of a novel fibronectin isoform expressed in cartilaginous tissues. J. Biol. Chem., 278, 50546-50553, 2003.
Shigeta, M., Sanzen, N., Gu, J., Hasegawa, H., and Sekiguchi, K.
CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization. J. Cell Biol., 163, 165-176, 2003.
Khazenzon, N. M., Ljubimov, A. V., Lakhter, A. J., Fujita, M., Fujiwara, H., Sekiguchi, K., Sorokin, L. M., Petajanieme, N., Virtanen, I., Black, K. L., and Ljubimova, J. Y.
Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro. Molecular Cancer Therapeutics, 2, 985-994, 2003.
Nishiuchi, R., Murayama, O., Fujiwara, H., Gu, J., Kawakami, T., Aimoto, S., Wada, Y., and Sekiguchi, K.
Characterization of ligand binding specificities of integrin a3b1 and a6b1 using a panel of purified laminin isoforms containing distinct a chains. J. Biochem., 134, 497-504, 2003.
Hattori, K., Mabuchi, R., Fujiwara, H., Sanzen, N., Sekiguchi, K., Kawai, K., and Akaza, H.
Laminin expression patterns in human ureteral tissue. J. Urol., 170, 2040-2043, 2003.
Nagakubo, D., Murai, T., Tanaka, T., Usui, T., Matsumoto, M., Sekiguchi, K., and Miyasaka, M.
A high endothelial venule secretory protein, Mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines. J. Immunol., 171:553-561, 2003.
Gu, J., Nada, S., Okada, M., and Sekiguchi, K.
Csk regulates integrin-mediated signals: involvement of differential activation of ERK and Akt. Biochem. Biophys. Res. Commun., 303:973-977, 2003.
Niimi, T., Hayashi, Y., and Sekiguchi, K.
Identification of an upstream enhancer in the mouse laminin α1 gene
defining its high level of expression in parietal endoderm cells. J. Biol. Chem., 278:9332-9338, 2003.
Katayama, M., Sanzen, N., Funakoshi, A., and Sekiguchi, K
Laminin γ2-chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion. Cancer Res., 63:222-229, 2003.
2002
Hayashi, Y., Kim, K.H., Fujiwara, H., Shimono, C., Yamashita, M., Sanzen, N., Futaki, S., and Sekiguchi. K.
Identification and recombinant production of human laminin a4 subunit splice variants. Biochem. Biophys. Res. Commun., 299:498-504, 2002.
Tomohiko Fukuda, Nobuaki Yoshida, Yuki Kataoka, Ri-ichiroh Manabe , Yoko Mizuno-Horikawa, Motohiko Sato, Kouji Kuriyama, Natsuo Yasui, and Kiyotoshi Sekiguchi
Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res., 62:5603-5610, 2002.
Jianguo Gu, Ryoko Nishiuchi, and Kiyotoshi Sekiguchi
Matrix metalloproteinase-2 is involved in A549 cell migratioin on laminin-10/11. Biochem. Biophys. Res. Commun., 296:73-77, 2002.
N. Petajaniemi, M. Korhonen, J. Kortesmaa, K. Tryggvasion, K. Sekiguchi , H. Fujiwara, L. Sorokin, L.-E. Thornell, Z. Wondimu, D. Assefa, M. Patarroyo, and I. Virtanen
Localizatiion of laminin a4-chain in developing and adult huma tissues and laminin-8 in the adhesion of endothelial cells. J. Histochem. Cytochem., 50:1113-1130, 2002.
Jianguo Gu, Akemi Fujibayashi, Kenneth M. Yamada, and Kiyotoshi Sekiguchi
Laminin-10/11 and Fibronectin differentially prevent apoptosis induced by serum removal via PI3-kinase/Akt- and MEK1/ERK-dependent pathways. J. Biol. Chem., 272, 19922-19928, 2002.
Kentaro Shiraki, Shigemi Norioka, Shaoliang Li, and Fumio Sakiyama
Contribution of an imidazole-indol stack to high catalytic potency of a lysine-specific serine protease, Achromobacter protease I. J. Biochem.131, 213-218(2002)
2001
Jianguo Gu, Yasuhiro Sumida, Noriko Sanzen, and Kiyotoshi Sekiguchi
Laminin-10/11 and Fibronectin Differentially Regulate Integrin-dependent Rho and Rac Activation Via p130cas-CrkⅡ-Dock180 Pathway. J. Biol. Chem 276:29,27090-27097 .2001
Matsui, Y., Nakata, K., Araki, N., Ozono, K., Fujita, Y., Tsumaki, N., Kawabata, H., Yasui, N.,Sekiguchi, K., and Yoshikawa, H.
Alternative splicing of fibronectin transcripts in osteochondrogenic tumors. Anticancer Res. 21(2A):1103-1106, 2001.
Fujiwara, H., Kikkawa, Y., Sanzen, N., and Sekiguchi, K.
Purification and characterization of human laminin-8: laminin-8 stimulates cell adhesion and migration through a3b1 and a6b1 integrins. J. Biol. Chem. 276:17550-17558, 2001.
2000
Satoi, S., Kitabe, H., Hiramatsu, Y., Kwon, A-H., Yakahashi, H., Sekiguchi, K., Uehara, M., Oda, M., Yanagimoto, Y., Miyashita, K., Sakashita, E., and Kamiyama, Y.
Increased extra domain-A containing fibronectin and hepatic dysfunction during septic response: an in vivo and in vitro study. SHOCK 13:492-496, 2000.
Fleischmajor, R., Kuroda, K., Utani, A., MacDonald, E. D., Perlish, J. S., Arikawa-Hirasawa, E., Sekiguchi, K., Sanzen, N., Timpl, R., and Yamada, Y.
Differential expression of laminin a chains during proliferative and differentiation stages of skin morphogenesis. Matrix Biol. 19:637-647, 2000.
Naito, M., Fukuda, T., Sekiguchi, K., and Yamada, T.
The domains of human fibronectin mediating the binding of a antigen, the most immuno-potent antigen of mycobacteria that induces protective immunity against mycobacterial infection. Biochem. J. 347:725-731, 2000.
Kikkawa, Y., Sanzen, N., Fujiwara, H., and Sekiguchi, K.
Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by a3b1, a6b1, and a6b4 integrins. J. Cell Sci. 113: 869-876, 2000.
Shaoliang Li, Shigemi Norioka, and Fumio Sakiyama
Purification, characterization and primary structure of a novel cell wall hydrolytic amidase, CwhA, from Achromobacter lyticus. J. Biochem. 127, 1033-1039, 2000.
1999
Satoi, S., Hiramatsu, Y., Kitade, H., Kwon, A.-H., Matsui, K., Miyashita, K., Sakashita, E., Sekiguchi, K., Takahashi, H., & Kamiyama, Y.
Different responses to surgical stress between extra domain A+ and plasma fibronectin. Clin. Exp. Pharmocol. Physiol. 26:225-229, 1999.
Tanaka, M., Tamaki, T., Kawamura, A., Yokota, N., Hayashi, T., Konoeda, Y., Yonekasa, M., Sanzen, N., & Sekiguchi, K.
A novel monitoring of kidney allograft rejection with plasma EDA(+) fibronectin. Transplantation Proc. 31:310-311, 1999.
Manabe, R., Oh-e, N., and Sekiguchi, K.
The alternatively spliced EDA segment regulates fibronectin-dependent cell cycle progression and mitogenic signal transduction.J. Biol. Chem. 274:5919-5924, 1999.
1998
Taylor, G.A., Jeffers, M., Webb, C.P., Koo, H., Anver, M., Sekiguchi, K. and Van de Woude, G.F.
Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. Oncogene 17: 1179-1183, 1998.
Kikkawa, Y., Sanzen, N., and Sekiguchi, K.
Isolation and characterization of laminin-10/11 secreted by huaman lung carcinoma cells Laminin-10/11 mediates cell adhesion through integrin a3b1. J. Biol. Chem. 273:15854-15860, 1998.
Fukushima, Y., Ohnishi, T., Arita, N., Hayakawa, T., and Sekiguchi, K
Integrin a3b1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells. Int. J. Cancer 76:63-72, 1998.
Shaoliang Li, Shigemi Norioka, and Fumio Sakiyama
Bacteriolytic activity and specificity of Achromobacter b-lytic protease. (1998) J. Biochem. 124, 332-339
　日本語の総説・著書など

2015年

藤田和将、関口清俊：II. 臨床応用を目指した基礎研究　再生医療を進めるための技術開発　“幹細胞培養基質の開発”
日本臨牀　73巻　増刊号5　＜再生医療－新たな医療を求めて－＞, 日本臨牀社, 342-346, 2015

2014年

関口清俊：再生医療普及のための基盤技術　“ヒト多能性幹細胞培養基質の開発”
最新医学・2014年・3月増刊号　＜再生医療の最新の進歩　（前篇）次世代再生医療に向けた基盤研究＞, 最新医学社, 685-697, 2014
谿口征雅、関口清俊：幹細胞培養基質の開発：現状と課題
生物工学会誌　第92巻　第9号, 468-499, 2014
2013年
川瀬栄八郎、宮崎隆道、関口清俊：“ラミニンE8を用いた安全で効率的なヒト多能性幹細胞培養法の開発”
実験医学 31, 918-922, 2013
関口清俊：“多能性幹細胞フィーダーフリー培養基材の開発”
臨床評価、41, 124-127、2013
佐藤祐哉、関口清俊：“神経－血管相互作用と細胞外マトリックス”
血管医学、14, 51-58, 2013
2012年
筒井仰、二木杉子、関口清俊：“細胞外マトリックスと幹細胞ニッチ”
再生医療 11, 220-238, 2012
2008年
藤原裕展、関口清俊：“細胞外マトリックスによるEMTの制御”
細胞工学　27, 321-325, 2008
関口清俊：“特集「細胞外基質―研究の新たな展開」に寄せて”
生体の科学 59, 82-83, 2008
藤原裕展、関口清俊：“初期胚細胞分化における基底膜の役割”
生体の科学 59, 111-117, 2008
2007年
関口清俊：“細胞間認識・接着”
生物物理学ハンドブック（石渡信一、桂　勲、桐野豊、三宅成樹　編）、第4章-IV 4.13, 朝倉書店、2007
関口清俊：“再生医療・細胞組織工学のためのマトリックス生物学入門”
再生医療のための細胞生物学、コロナ社、1-25, 2007
山田雅司、関口清俊：“細胞外マトリックスと増殖因子：細胞を制御するシグナル伝達の分子機構”
再生医療のための細胞生物学、コロナ社、76-98, 2007
眞鍋理一郎、関口清俊：“マトリックス組込型増殖因子とマトリックス工学”
再生医療のための細胞生物学、コロナ社、158-172, 2007
西内涼子、関口清俊：“細胞接着因子の生物学”
ティッシュエンジニアリング（田畑泰彦、岡野光夫）、日本医学館、88-95, 2007
浄住大慈、関口清俊：“基底膜のカスタマイゼーションとその器官形成における役割”
THE LUNG Perspectives 15, 80-84, 2007
佐藤（西内）涼子、関口清俊：“インテグリンを中心としたタンパク質間相互作用”
生体の科学（増大特集号　タンパク-タンパク相互作用）　58, 426-427, 2007
二木杉子、関口清俊：“細胞外環境による形態形成の制御：新しい生物学の胎動、基底膜の多様性と形態形成の制御”
細胞工学　26, 1113-1117, 2007
2005年
二木　杉子、関口清俊：“細胞外微小環境─幹細胞のニッチを支える細胞外マトリックス”
BIOINDUSTRY 22, 52-55, 2005
浄住大慈、関口清俊：“最適化された細胞外環境を提供する細胞外マトリックス”
実験医学（増刊） 22, 52-55, 2005
井戸寛之、関口清俊：“ティッシュエンジニアリングと基底膜”
ティッシュエンジニアリング2005（田畑康彦、岡野光夫編）、日本医学館 pp.37-44, 2005.
関口清俊：“細胞外マトリックスとその実験法”
細胞生物学実験法（大熊勝治編）、広川書店、47-71, 2005.
2004年
眞鍋理一郎、関口清俊：“ティシュエンジニアリング・再生医療のためのテーラーメイド環境設計”
再生医療 3, 13-21, 2004.
福田友彦、関口清俊：“インテグリン連関キナーゼ”
生体の科学 55, 432-433, 2004.
林　良敬、三千典子、関口清俊：“再生医療工学のためのテーラーメイド環境設計”
高分子 53, 134-139, 2004.
2002年
関口清俊：“細胞外マトリックスの多様性とインテグリンシグナリング”
実験医学（増刊「蛋白質研究の最前線」）20, 124-132, 2002.
2001年
顧　建国、李　紹良、関口清俊：“ラミニン結合性インテグリンを介するシグナル伝達とその制御”
生化学、73:1207-1214, 2001.
西内涼子、関口清俊：“フィブロネクチンIII型モジュール”
生体の科学、52:468-469, 2001.
西内涼子、関口清俊：“RGD細胞接着モチーフ”
生体の科学、52:464-465, 2001.
関口清俊・鈴木信太郎（編）：”「多細胞体の構築と細胞接着システム」”
（シリーズバイオサイエンスの新世紀　第８巻）、共立出版、2001.
関口清俊：“細胞-基質間接着分子機構とシグナル伝達”
「多細胞体の構築と細胞接着システム」　　（シリーズバイオサイエンスの新世紀　第８巻、関口清俊・鈴木信太郎編）、pp.00-123,共立出版、　2001.
顧　建国、関口清俊：“プロテインチロシンホスファターゼと癌抑制遺伝子PTEN”
（医学研究のため　のテクニカルダイダンス、谷口直之編）、pp.131-139, メディカルビュー社、2000.
関口清俊：“細胞外マトリックス接着機構：基礎知識”
（細胞外マトリックス実験法、第５巻、畑　隆一郎・服部俊治・新井克彦編）、pp.5-8、コラーゲン技術研修会、1999
福田友彦、関口清俊：“フィブロネクチン”
「ノックアウトマウスデータブック」（黒川清・野口　茂・笹月健彦・平井久丸編）、pp.174-175、中山書店、1997
関口清俊： “フィブロネクチン”
「バイオサイエンス用語ライブラリー：細胞接着」（宮坂昌之・矢原一郎編）、pp.62-63、羊土社、1996.
関口清俊：“インテグリン”
「バイオサイエンス用語ライブラリー：細胞内シグナル伝達」（山本雅　編）、PP.54-55、羊土社、1995
前田利長、関口清俊：“接着タンパク質の構造と機能：フィブロネクチン，ビトロネクチン，トロンボ　スポンディン，インテグリン”
「血栓、止血、線溶」（松田道生・鈴木宏治編）、PP.26-32,中外医　学社、1994
関口清俊：“細胞の接着と癌化”
「タンパク質は変化する：癌・老化・糖尿病に挑戦する生命科学」　（第７回大学と科学　公開シンポジウム講演集）、pp.143-155, クバプロ、1993.
2000年
福田友彦、関口清俊：“Integrin-linked kinase”
生体の科学、51:614-615, 2000.
福田友彦、関口清俊：“フィブロネクチンと疾患”
病理と臨床、18:358-363, 2000.
関口清俊：“細胞・組織レベルでの機構を理解する”
化学 55:24, 2000.
顧　建国、関口清俊：“プロテインチロシンホスファターゼと癌抑制遺伝子PTEN”
The Lung Perspectives 8:106-111, 2000.
1998年
真鍋理一郎、関口清俊：“マトリックス工学--新規細胞外マトリックス分子の創出と細胞の機能制御”
結合組織 30:57-62, 1998.
新井浩和、関口清俊：“胎児肺の発達とフィブロネクチン”
大阪府立母子医療センター雑誌 14:71-76, 1998.


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