Protein molecules spontaneously fold into unique three-dimensional
structures specified by their amino acid sequences from random coils
to carry out their functions. The protein sequence space is enormously
vast. Naturally occurring proteins represent only a tiny fraction of
this immense sequence space. In our laboratory, by using both
computational and experimental approaches, we aim to develop
fundamental principles and methodologies for designing protein
molecules. Our goal is to explore this vast, unexplored sequence space
and discover novel proteins within it.
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①Protein design often begins with a rough blueprint of the protein to be created.
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②Next, based on the blueprint, the three-dimensional structure of the protein is constructed on a computer.
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③The three-dimensional structure created by the computer is evaluated from various perspectives. If the structure differs from the expected structure, the blueprint is revised and the structure is constructed again.
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④Finally, we examine how the computationally designed protein behaves in the experiment.
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