タンパク質有機化学研究室

出版物リスト

北條 裕信

  • I. Suetake, K. Sato, T. Sugishita, Y. Mishima, T. Takei, T. Fujiwara, R. Mutoh, A. Shinohara, T. Takui, M. Miyata, H. Hojo, T. Arata, Dynamics of the HP1 Hinge Region with DNA Measured by Site-Directed Spin Labeling-EPR Spectroscopy, Applied Magnetic Resonance, 54, 119-141, 2023. doi: 10.1007/s00723-022-01519-2
  • T. Takei, H. Tanaka, L. Moroder, H. Hojo Chemical synthesis of per-selenocysteine human epidermal growth factor, J Pept Sci. 2022;e3464. DOI: 10.1002/psc.3464
  • S. Hanashima, M. Mito, Y. Umegawa M. Murata, H. Hojo, Lipid chain-driven interaction of a lipidated Src-family kinase Lyn with the bilayer membrane Org. Biomol Chem. 20, 6436-6444. DOI:/10.1039/D2OB01079H
  • Y. Asahina, T. Andoh, H. Hojo, Toward the Chemical Syntheses of Fucosylated Peptides: A Combination of Protecting Groups for the Hydroxy Groups of Fucose Bull. Chem. Soc. Jpn. 2022, 95, 1196–1208. DOI:10.1246/bcsj.20220037
  • Toru Kawakami, Eri Sasakura, Yohei Miyanoiri, Hironobu Hojo, Relative configuration of Cys-Pro ester peptides in thioester formation, J Pept Sci. 2022;e3406. DOI:10.1002/psc.3406
  • Takahiro Imanishi, Koji Nishikawa, Midori Taketa, Katsuhiro Higuchi, Hulin Tai, Shun Hirota, Hironobu Hojo, Toru Kawakami, Kiriko Hataguchi, Kayoko Matsumoto, Hideaki Ogata and Yoshiki Higuchi, Structural and spectroscopic characterization of CO inhibition of [NiFe]-hydrogenase from Citrobacter sp. S-77, Acta Cryst. (2022). F78, 66–74. DOI:10.1107/S2053230X22000188
  • M. Nakano, S. Hanashima, T. Hara, K. Kabayama, Y. Asahina, H. Hojo, N. Komura, H. Ando, T.K.M. Nyholm, J.P. Slotte, M. Murata, FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers, Biochim. Biophys. Acta- Biomembranes, 1863(8), 183623-183623 (2021). DOI:10.1016/j.bbamem.2021.183623
  • S. Ito, Y. Asahina, H. Hojo, Investigation of protecting group for sialic acid carboxy moiety toward sialylglycopeptide synthesis by the TFA-labile protection strategy, Tetrahedron, 2021, 97, 132423. DOI:10.1016/j.tet.2021.132423
  • I. Suetake, S. Nakazawa, K. Sato, R. Mutoh, Y. Mishima, T. Kawakami, T. Takei, M. Watanabe, N. Sakai, T. Fujiwara, T. Takui, M. Miyata, A. Shinohara, H. Hojo, T. Arata, Structural dynamics of the chromo-shadow domain and chromodomain of HP1 bound to histone H3K9 methylated peptide as measured by site-directed spin-labeling EPR spectroscopy, Biochem. Biophys. Res. Commun., 567 (2021) 42-48. DOI:10.1016/j.bbrc.2021.06.010
  • H. Hojo, T. Takei, Y. Asahina, N. Okumura, T. Takao, M. So, I. Suetake, T. Sato, A. Kawamoto, Y. Hirabayashi, Total synthesis and structural characterization of caveolin-1, Angewandte Chem. Int. Ed., 56, 14239-14242. DOI: 10.1002/anie.202100826
  • H. Hojo, I. Suetake, Chemical synthesis of palmitoylated histone H4, Arkivoc 2021, part iv, 186-197. DOI: 10.24820/ark.5550190.p011.361
  • T. Takei, T. Ando, T. Takao, Y. Ohnishi, G. Kurisu, M. Iwaoka, H. Hojo, Chemical synthesis of ferredoxin with 4 selenocysteine residues using a segment condensation method, Chem. Commun., 2020, 56, 14239-14242. DOI: 10.1039/d0cc06252a
  • E. J. Crooks, B. A. Irizarry, M. Ziliox, T. Kawakami, T. Victor, F. Xu, H. Hojo, K. Chiu, C. Simmerling, W. E. Van Nostrand, S. O. Smith, L. M. Miller, Copper stabilizes antiparallel b-sheet fibrils of the amyloid b40 (Ab40)-Iowa variant, J. Biol. Chem. 295(27) 8914–8927 (2020). DOI: 10.1074/jbc.RA119.011955
  • A. Nishiyama, C. B. Mulholland, S. Bultmann, S. Kori, A. Endo, Y. Saeki, W. Qin, C. Trummer, Y. Chiba, H. Yokoyama, S. Kumamoto, T. Kawakami, H. Hojo, G. Nagae, H. Aburatani, K. Tanaka, K. Arita, H. Leonhardt, M. Nakanishi, Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation, Nature Commun, 11, 1222 (2020). DOI: 10.1038/s41467-020-15006-4
  • C. P. R. Hackenberger, P.E. Dawson, Y.X. Chen, H Hojo, Modern Peptide and Protein Chemistry: Reaching New Heights, J. Org. Chem., 85, 1328-1330 (2020). DOI:10.1021/acs.joc.0c00104
  • Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, J. Otani, A. Shinohara, K. Takeshita, R.G. Garvilles, M. Watanabe, N. Sakai, H. Takeshima, C. Nachtegael, A. Nishiyama, M. Nakanishi, K. Arita, K. Nakashima, H. Hojo, I. Suetake, Enhanced processivity of Dnmt1 by monoubiquitinated histone H3, Genes Cells 25, 22-32 (2020). DOI: 10.1111/gtc.12732
  • G. Serra, L. Posada, H. Hojo, On-resin synthesis of cyclic peptides via tandem N-to-S acyl migration and intramolecular thiol additive-free native chemical ligation, Chem. Commun. 2020, 56, 956-959 DOI:10.1039/c9cc07783a
  • Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, J. Otani, A. Shinohara, K. Takeshita, R.G. Garvilles, M. Watanabe, N. Sakai, H. Takeshima, C. Nachtegael, A. Nishiyama, M. Nakanishi, K. Arita, K. Nakashima, H. Hojo, I. Suetake, Enhanced processivity of Dnmt1 by monoubiquitinated histone H3, Genes Cells. 2019. DOI:10.1111/gtc.12732
  • Y. Asahina, H. Hojo, One step synthesis of Fmoc-aminoacyl-N-alkylcysteine via the Ugi four-component condensation reaction, J. Org. Chem., 2019. DOI: 10.1021/acs.joc.9b02433
  • T Kawakami, Y, Mishima, M. Takazawa, H. Hojo, I. Suetake, Chemical synthesis of the ubiquitinated form of histone H3 and its effect on DNA methyltransferase 1, J. Pep Sci.2019;25:e3200. DOI: 10.1002/psc.3200
  • Y. Asahina, T. Kawakami, H. Hojo, Glycopeptide Synthesis Based on a TFA-Labile ProtectionStrategy and One-Pot Four-Segment Ligation for the Synthesis of O-Glycosylated Histone H2A, Eur. J. Org. Chem. 2019, 1915–1920 (2019). DOI: 10.1002/ejoc.201801885
  • S. Inouye, H. Hojo, Revalidation of recombinant aequorin as a light emission standard: Estimation of specific activity of Gaussia luciferase, DOI:10.1016/j.bbrc.2018.11.015
  • M. Noji, M. So, K. Yamaguchi, H. Hojo, M. Onda, Y. Akazawa-Ogawa, Y. Hagihara, Y. Goto, Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization, Biochemistry 2018, 57, 5415−5426. DOI:10.1021/acs.biochem.8b00619
  • S. Shimodira, T.Takei, H. Hojo, M. Iwaoka, Synthesis of selenocysteine-containing cyclic peptides via tandem N-to-S acyl migration and intramolecular selenocysteine-mediated native chemical ligation, Chem. Commun., 2018, 54, 11737-11740, DOI: 10.1039/c8cc06805d
  • K. Arai, T. Takei, R. Shinozaki, M. Noguchi, S. Fujisawa, H. Katayama, L. Moroder, S. Ando, M. Okumura, K. Inaba, H. Hojo, M. Iwaoka, Characterization and optimization of two-chain folding pathways of insulin via native chain assembly, COMMS CHEM (2018)1:26, DOI: 10.1038/s42004-018-0024-0
  • N. Takeda, T. Takei, Y. Asahina, and H. Hojo, Sialyl Tn Unit with TFA-Labile Protection Realizes Efficient Synthesis of Sialyl Glycoprotein Chem. Eur.J. 2018, 24,2593 2597, DOI: 10.1002/chem.201706127
  • Iwaoka M, Suzuki T, Shoji Y, Dedachi K, Shimosato T, Minezaki T, Hojo H, Onuki H, Hirota H. Development of SAAP3D force field and the application to replica-exchange Monte Carlo simulation for chignolin and C-peptide. J Comput Aided Mol Des. 2017, 31(12):1039-1052. DOI: 10.1007/s10822-017-0084-8.
  • H. Hojo, T. Kawakami, Y. Hiroyama, S. Aimoto, An N-protection free ligation of the peptide thioester and the peptide with N-alkoxy- or N-aryloxyamino group at its N-terminus, Tetrahedron Lett., 58, 4638-4641 (2017) doi.org/10.1016/j.tetlet.2017.10.074
  • S. Ishiyama, A. Nishiyama, Y. Saeki, K. Moritsugu, D. Morimoto, L. Yamaguchi, N. Arai, R. Matsumura, T. Kawakami, Y. Mishima, H. Hojo, S. Shimamura, F. Ishikawa, S. Tajima, K. Tanaka, M. Ariyoshi, M. Shirakawa, M. Ikeguchi, A. Kidera, I. Suetake, K. Arita, M. Nakanishi, Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance, Mol Cell 68, 350360, October 19, 2017. DOI: 10.1016/j.molcel.2017.09.037
  • T. Takei, T. Andoh, T. Takao, H. Hojo, One-Pot Four-Segment Ligation using Seleno- and Thioesters: Synthesis of Superoxide Dismutase, Angewandte Chem. Int. Ed. 56, 15708 15711 (2017). DOI: 10.1002/anie.201709418
  • Y. Mishima, L. Brueckner, S. Takahashi, T. Kawakami, K. Arita, S. Oka, J. Otani, H. Hojo, M. Shirakawa, A. Shinohara, M. Watanabe, I. Suetake, RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails, FEBS J. 284 (2017) 34553469. DOI: 10.1111/febs.14205
  • D. Kobayashi, M. Endo, H. Ochi, H. Hojo, M. Miyasaka, H. Hayasaka, Regulation of CCR7-dependent cell migration through CCR7 homodimer formation, Sci Rep, 7: 8536 2017. DOI: 10.1038/s41598-017-09113-4
  • A. Katsuyama, A. Paudel, S. Panthee, H. Hamamoto, T. Kawakami, H. Hojo, F. Yakushiji, S. Ichikawa, Total synthesis and antibacterial investigation of plusbacin A3, Org. Lett. 2017, 19, 37713774. DOI: 10.1021/acs.orglett.7b01629
  • T. Kawakami, Y. Mishima, H. Hojo, I. Suetake, Synthesis of ubiquitylated histone H3 using a thiirane linker for chemical ligation, J. Pept. Sci. 23: 532538 (2017). DOI: 10.1002/psc.2976
  • P. Gunasekaran, S.R. Lee, S.M. Jeong, J.W. Kwon, T. Takei, Y. Asahina, G. Bang, S. Kim, M. Ahn, E.K. Ryu, H.N. Kim, K.Y. Nam, S.Y. Shin, H. Hojo, S. Namgoong, N.H. Kim, J.K. Bang, Pyrrole-based macrocyclic small-molecule inhibitors that target oocyte maturation, ChemMedChem, 12, 580-589 (2017). DOI: 10.1002/cmdc.201700048
  • K. Arai, T. Takei, M. Okumura, S. Watanabe, Y. Amagai, Y. Asahina, L. Moroder, H. Hojo, K. Inaba, M. Iwaoka, Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue, Angewandte Chem. Int. Ed. 56, 5522-5526 (2017). DOI: 10.1002/anie.201701654
  • Y. Asahina, T. Kawakami, H. Hojo. One-pot native chemical ligation by combination of two orthogonal thioester precursors, Chem. Commun., 2017, 53, 2114-2117 DOI: 10.1039/c6cc10243c
  • S. Iida, T. Mashimo, T. Kurosawa, H. Hojo, H. Muta, Y. Goto, Y. Fukunishi, H. Nakamura, J. Higo. Variation of Free-Energy Landscape of the p53 C-Terminal Domain Induced by Acetylation: Enhanced Conformational Sampling, J Comput Chem 2016, 37, 2687-2700. DOI: 10.1002/jcc.24494
  • Y. Takechi-Haraya, R. Nadai, H. Kimura, K. Nishitsuji, K. Uchimura, K. Sakai-Kato, K. Kawakami, A. Shigenaga, T. Kawakami, A. Otaka , H. Hojo, N. Sakashita, H. Saito. Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides, Biochim Biophys Acta 1858 (2016) 1339-1349. DOI: 10.1016/j.bbamem.2016.03.021
  • Y. Mishima, C.D. Jayasinghe, K. Lu, J. Otani, M. Shirakawa, T. Kawakami, H. Kimura, H. Hojo, P. Carlton, S. Tajima, I. Suetake. Nucleosome compaction facilitates HP1 gamma binding to methylated H3K9, Nucleic Acids Res, 43, 10200-10212 (2015). DOI: 10.1093/nar/gkv841
  • A. Yoneshige, M. Muto, T. Watanabe, H. Hojo, J. Matsuda, The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase, Clin. Biochem., 48, 1177-1180, 2015. DOI: 10.1016/j.clinbiochem.2015.06.004
  • T. Kawakami, R. Yoshikawa, Y. Fujiyoshi, Y. Mishima, H. Hojo, S. Tajima, I. Suetake, Synthesis of Histone Proteins by CPE Ligation using a Recombinant Peptide as the C-Terminal Building Block. J. Biochem. 2015;158(5):403411, DOI: 10.1093/jb/mvv056
  • Y. Asahina, S. Komiya, A. Ohagi, R. Fujimoto, H. Tamagaki, K. Nakagawa, T. Sato, S. Akira, T. Takao, A. Ishii, Y. Nakahara, H. Hojo. Chemical Synthesis of O-glycosylated human interleukin-2 by the reverse polarity protection strategy. Angew. Chem. Int. Ed. 54, 8226-8230 (2015). DOI:10.1002/anie.201501847
  • Y. Asahina, K. Nabeshima, H. Hojo. Peptidyl N-alkylcysteine as a peptide thioester surrogate in the native chemical ligation. Tetrahedron Lett., 56, 1370-1373 (2015) . DOI:10.1016/j.tetlet.2015.01.095
  • Y. Asahina, K. Nabeshima, H. Hojo. Peptidyl N-alkylcysteine as a peptide thioester surrogate in the native chemical ligation. Tetrahedron Lett., 56, 1370-1373 (2015) . DOI:10.1016/j.tetlet.2015.01.095
  • A. Taguchi, K. Fukumoto, Y. Asahina, A. Kajiyama, S. Shimura, K. Hamada, K. Takayama, F. Yakushiji, H. Hojo and Y. Hayashi. 3-Nitro-2-pyridinesulfenyl-mediated solid-phase disulfide ligation in the synthesis of disulfide bond-containing cyclic peptides. Org. Biomol. Chem., 2015, 13, 3186-3189.DOI:10.1039/c5ob00030k
  • T. Hara, Y. Huang, A. Ito, T. Kawakami, H. Hojo, M. Murata. Trifluoroethanol-containing RP-HPLC mobile phases for the separation of transmembrane peptides human p24 : analysis and prevention of potential side reactions due to formic acid. J. Pept. Sci., 21, 61-70 (2015). DOI:10.1002/psc.2717
  • Y. Asahina, K. Nabeshima, H. Hojo. Peptidyl N-alkylcysteine as a peptide thioester surrogate in the native chemical ligation. Tetrahedron Lett., 56, 1370-1373 (2015) . DOI:10.1016/j.tetlet.2015.01.095
  • Y. Asahina, R. Fujimoto, A. Suzuki, H. Hojo. Synthesis of Fmoc-Thr Unit Carrying Core 1 O-Linked Sugar With Acid-Sensitive O-Protecting Group and Its Application to the Synthesis of Glycosylated Peptide Thioester. J. Carbohydr. Chem. 34, 12-27 (2015) . DOI:10.1080/07328303.2014.977909
  • T. Takei, Y. Urabe, Y. Asahina, H. Hojo, T. Nomura, K. Dedachi, K. Arai, M. Iwaoka. Model Study Using Designed Selenopeptides on the Importance of the Catalytic Triad for the Antioxidative Functions of Glutathione Peroxidase. J. Phys. Chem. B, 118, 492-500 (2014) . DOI:10.1021/jp4113975
  • T. Takenouchi, H. Katayama, Y. Nakahara, Y. Nakahara and H. Hojo. A novel post-ligation thioesterification device enables peptide ligation in the N to C direction: synthetic study of human glycodelin J. Pept. Sci., 20, 55-61 (2013).DOI:10.1002/psc.2592
  • Y. Asahina, M. Kanda, A. Suzuki, H. Katayama, Y. Nakahara, H. Hojo. Fast Preparation of an N-Acetylglucosaminylated Peptide Segment for the Chemoenzymatic Synthesis of a Glycoprotein. Org. Biomol. Chem., 11, 7199-7207 (2013). DOI:10.1039/c3ob41565a
  • Y. Asahina, S. Kamitori, T. Takao, N. Nishi, H. Hojo. Chemoenzymatic Synthesis of the Immunoglobulin Domain of Tim-3 Carrying a Complex-Type N-Glycan by Using a One-pot Ligation. Angew. Chem. Int. Ed., 52, 9733-9737 (2013). DOI:10.1002/anie.201303073
  • H. Katayama and H. Hojo The phenacyl group as an efficient thiol protecting group in a peptide condensation reaction by the thioester method. Org. Biomol. Chem., 11, 4405-4413 (2013).DOI:10.1039/c3ob40644j
  • A. Wada, P.-F. Wong, H. Hojo, M. Hasegawa, A. Ichinose, R. Llanes, Y. Kubo, M. Senba, Y. Ichinose Alarin but not its alternative-splicing form, GALP (Galanin-likepeptide) has antimicrobial activity. BBRC. , 434 , 223-227 (2013).DOI:10.1016/j.bbrc.2013.03.045
  • H. Hojo, H. Tanaka, M. Hagiwara, Y. Asahina, A. Ueki, H. Katayama, Y. Nakahara, A. Yoneshige, J. Matsuda, Y. Ito, Y. Nakahara. Chemoenzymatic Synthesis of Hydrophobic Glycoprotein. Synthesis of Saposin C Carrying Complex-type Carbohydrate. J. Org. Chem., 77, 9437-9446 (2012). DOI:10.1021/jo3010155
  • H. Katayama, K. Nozawa, O. Nureki, Y. Nakahara, H. Hojo Pyrrolysine Analogs as substrates for bacterial pyrrolysyl-tRNA synthetase in vitro and in vivo. Biosci. Biotechnol. Biochem., 76, 205-208 (2012).DOI:10.1016/j.bbrc.2013.03.045
  • Y. Sohma, H. Kitamura, H. Kawashima, H. Hojo, M. Yamashita, K. Akaji, Y. Kiso Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide. Tetrahedron Lett., 52, 7146-7148 (2011).DOI:10.1016/j.tetlet.2011.10.116
  • H. Katayama, Y. Asahina, H. Hojo. Chemical Synthesis of the S-Linked Glycopeptide, Sublancin. J. Pept. Sci. 17, 818-821 (2011). DOI:10.1002/psc.1406
  • T. Kawakami, T. Sameshima, H. Hojo, K. Koga, Y. Nakahara, B.P. Toole, J. Suzumiya, Y. Okada, A. Iwasaki, K. Nabeshima Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts. BMC Cancer, 11, 300 (2011)DOI:10.1186/1471-2407-11-300
  • H. Hojo, H. Kobayashi, R. Ubagai, Y. Asahina, Y. Nakahara, H. Katayama, Y. Ito, Y. Nakahara. Efficient Preparation of Fmoc-aminoacyl-N-ethylcysteine Unit, a Key Device for the Synthesis of Peptide Thioesters. Org. Biomol. Chem., 9, 6807-6813 (2011). DOI:10.1039/c1ob05831b
  • M. Hagiwara, M. Dohi, Y. Nakahara, K. Komatsu, Y. Asahina, A. Ueki, H. Hojo, Y. Nakahara, Y. Ito, Synthesis of Biantennary Complex-type Nonasaccharyl Asn Building Blocks for Solid-phase Glycopeptide Synthesis. J. Org. Chem., 76, 5229-5239 (2011). DOI:10.1021/jo200149d
  • H. Katayama, Y. Nakahara, H. Hojo N-Methyl-phenacyloxycarbamidomethyl (Pocam) group: a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions. Org. Biomol. Chem., 9, 4653-4661 (2011)DOI:10.1039/c1ob05253e
  • S. Yoshida, F. Kumakura, I. Komatsu, K. Arai, Y. Onuma, H. Hojo, B.G. Singh, I. Priyadarsini, M. Iwaoka Antioxidative Glutathione Peroxidase Activity of Selenoglutathione. Angew. Chem. Int. Ed., 50, 2125-2128 (2011).
  • DOI:10.1002/anie.201006939
  • H. Hojo, H. Katayama, C. Tano, Y. Nakahara, A. Yoneshige, J. Matsuda, Y. Sohma, Y. Kiso, Y. Nakahara, Synthesis of the sphingolipid activator protein, saposin C, using an azido-protected O-acyl isopeptide as an aggregation-disrupting element. Tetrahedron Lett., 52, 635?639 (2011).
  • H. Hojo, C. Ozawa, H. Katayama, A. Ueki, Y. Nakahara, Y. Nakahara The Mercaptomethyl Group Facilitates an Efficient One-Pot Ligation at Xaa-Ser/Thr for (Glyco)peptide Synthesis. Angew. Chem. Int. Ed. 49, 5318-5321 (2010).DOI:
  • H. Katayama, H. Hojo, I. Shimizu, Y. Nakahara, Y. Nakahara Chemical synthesis of mouse pro-opiomelanocortin(1-74) by azido-protected glycopeptide ligation via the thioester method. Org. Biomol. Chem., 8, 1966 ? 1972 (2010).
  • A. Wada, M. Hasegawa, P.-F. Wong, E Shirai, N. Shirai, L.J. Tan, R. Llanes, H. Hojo, E. Yamasaki, A. Ichinose, Y. Ichinose, M. Senba Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity. Glycobiology, 20, 668 - 678 (2010).
  • A. Ueki, Y. Takano, A. Kobayashi, Y. Nakahara, H. Hojo, Y. Nakahara Solid-phase synthesis of glycopeptide carrying a tetra-N-acetyllactosaminecontaining core 2 decasaccharide Tetrahedron, 66, 1742?1759 (2010).
  • H. Katayama, H. Hojo, T. Ohira, A. Ishii, T. Nozaki, K. Goto, T. Takahashi, Y. Hasegawa, H. Nagasawa, Y. Nakahara Correct disulfide pairing is required for the biological activity of crustacean androgenic gland hormone (AGH): Synthetic studies of AGH. Biochemistry, 49, 1798?1807 (2010)
  • Biochem. Biophys. Res. Commun., 391, 557?563 (2010)
  • Y. Nakahara, I. Matsuo, Y., Ito, R. Ubagai, H. Hojo, Y. Nakahara High-pressure-promoted Fmoc-aminoacylation of N-ethylcysteine: preparation of key devices for the solid-phase synthesis of peptide thioesters. Tetrahedron Lett., 51, 407?410 (2010)
  • K. Kawahira, H. Tanaka, A. Ueki, Y. Nakahara, H. Hojo, Y. Nakahara Solid-phase synthesis of O-sulfated glycopeptide by the benzyl-protected glycan strategy. Tetrahedron, 65, 8143?8153 (2009).
  • H. Katayama, T. Utsumi, C. Ozawa, Y. Nakahara, H. Hojo, Y. Nakahara Pyruvoyl, a novel amino protecting group on the solid phase peptide synthesis and the peptide condensation reaction. Tetrahedron Lett., 50, 818?821 (2009).
  • C. Ozawa, H. Katayama, H. Hojo, Y. Nakahara, Y. Nakahara Efficient sequential segment coupling using N-alkylcysteine-assisted thioesterification for glycopeptides dendrimer synthesis. Org. Lett., 10, 3531-3533 (2008)
  • H. Katayama, H. Hojo, T. Ohira, Y. Nakahara An efficient peptide ligation using azido-protected peptides via the thioester method. Tetrahedron Lett., 49, 5492-5494 (2008).
  • H. Hojo, Y. Murasawa, H. Katayama, T. Ohira, Y. Nakahara, Y. Nakahara Application of a novel thioesterification reaction to the synthesis of chemokine CCL27 by the modified thioester method. Org. Bioorg. Chem., 6, 1808-1813 (2008)
  • A. Ueki, M. Hirota, Y. Kobayashi, K. Komatsu, Y. Takano, M. Iwaoka, Y. Nakahara, H. Hojo, Y. Nakahara Stereoselective synthesis of benzyl-protected ?-galactosides by propionitrile-mediated glycosylation. Tetrahedron, 64, 2611-2618 (2008).
  • C. Ozawa, H. Hojo, Y. Nakahara, H. Katayama, K. Nabeshima, T. Akahane, Y. Nakahara Synthesis of glycopeptide dendrimer by a convergent method. Tetrahedron, 63, 9685?9690 (2007)
  • K. Nakamura, H. Mori, T. Kawakami, H. Hojo, Y. Nakahara, S. Aimoto Peptide Thioester Synthesis via an Auxiliary-Mediated N ? S Acyl Shift Reaction in Solution. Int. J. Pept. Res. Ther., 191-202 (2007)
  • T. Ishimizu, K. Sano, T. Uchida, H. Teshima, K. Omichi, H. Hojo, Y. Nakahara, S. Hase Purification and Substrate Specificity of UDP-D-xylose:?-D-Glucoside -1,3-D-Xylosyltransferase Involved in the Biosynthesis of the Xyl1-3Xyl1-3Glc?1-O-Ser on Epidermal Growth Factor-like Domains. J. Biochem., 141, 593 ? 600 (2007).
  • A. Ueki, Y. Nakahara, H. Hojo, Y. Nakahara Synthesis of biantennary LacNAc-linked O-glycan(core4) and glycopeptide thioester by benzyl protection strategy: rapid zinc reduction of GlcNTCA to GlcNAc by microwave irradiation. Tetrahedron, 63, 2170?2181 (2007).
  • Y. Nakahara, C. Ozawa, E. Tanaka, K. Ohtsuka, Y. Takano, H. Hojo, Y. Nakahara Solid-phase synthesis of core3 and core6 O-glycan-linked glycopeptides by benzyl-protection method. Tetrahedron, 63, 2161?2169 (2007)
  • H. Hojo, Y. Onuma, Y. Akimoto, Y. Nakahara, Y. Nakahara N-Alkyl cysteine-assisted thioesterification of peptides. Tetrahedron Lett., 48, 25-28 (2007).
  • E. Tanaka, Y. Nakahara, Y. Kuroda, Y. Takano, N. Kojima, H. Hojo, Y. Nakahara Chemoenzymatic synthesis of a MUC1 glycopeptide carrying non-natural sialyl Tf-? O-glycan. Biosci. Biotechnol. Biochem., 70, 2515-2522 (2006).
  • F. Nagaike, Y. Onuma, C. Kanazawa, H. Hojo, A. Ueki, Y. Nakahara, Y. Nakahara An Efficient Microwave-Assisted Tandem N to S Acyl Transfer and Thioester Exchange for the Preparation of Glycosylated Peptide Thioester. Org. Lett., 8, 4465-4468 (2006).
  • K. Nabeshima, H. Iwasaki, K. Koga, H. Hojo, J. Suzumiya, M. Kikuchi Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays a critical role in cancer progression. Pathol. Int., 56, 359-367 (2006).
  • E. Haginoya, H. Hojo, Y. Nakahara, Y. Nakahara, K. Nabeshima, B. P. Toole, and Y. Watanabe Synthesis of a glycosylated peptide thioester by the Boc strategy and its application to segment condensation. Biosci. Biotechnol. Biochem., 70, 1338-1349 (2006).
  • H. Hojo, Y. Matsumoto, Y. Nakahara, E. Ito, Y. Suzuki, M. Suzuki, A. Suzuki, and Y. Nakahara Chemical Synthesis of 23 kDa Glycoprotein by Repetitive Segment Condensation: A Synthesis of MUC2 Basal Motif Carrying Multiple O-GalNAc Moieties. J. Am. Chem. Soc., 127, 13720-13725 (2005).
  • M. Maemura, A. Ohgaki, Y. Nakahara, H. Hojo, Y. Nakahara Solid-phase synthesis of core 8 O-glycan-linked MUC5AC glycopeptide. Biosci. Biotechnol. Biochem., 69, 1575-1583 (2005)
  • M. Kitamura, H. Hojo, Y. Nakahara, T. Ishimizu, S. Hase Synthesis and conformational characterization of the epidermal growth factor-like domain of blood coagulation factor IX carrying xylosyl-glucose. Glycoconjugate J., 21, 197-203 (2004).
  • Y. Takano, H. Hojo, N. Kojima, Y. Nakahara Synthesis of a mimic for the heterogeneous surface of core 2 sialoglycan-linked glycoprotein. Org. Lett., 6, 3135-3138 (2004)
  • T. Takemura, H. Hojo, Y. Nakahara, T. Ishimizu, S. Hase Application of Fmoc-amino acid carrying an unmasked carbohydrate to the synthesis of the epidermal growth factor-like domain of bovine blood coagulation factor IX. Org. Biomol. Chem. 2, 133-136 (2004).
  • Y. Takano, N. Kojima, Y. Nakahara, H. Hojo, Y. Nakahara Solid-phase synthesis of core 2 O-linked glycopeptide and its enzymatic sialylation. Tetrahedron, 59, 8415-8427 (2003)
  • Y. Nakahara, T. Nonaka, H. Hojo, and Y. Nakahara Synthesis of an Unusual N-glycan-linked Dolichyl Pyrophosphate Precursor. Biosci. Biotechnol. Biochem., 67, 1761-1766 (2003).
  • K. Yamauchi, H. Hojo, Y. Yamamoto, T. Tanabe Enhanced cell adhesion on RGDS-carrying keratin film. Materials Science and Engineering C, 23, 467-472 (2003).
  • Y. Tanaka, Y. Nakahara, H. Hojo and Y. Nakahara Studies directed toward the synthesis of protein-bound GPI anchor. Tetrahedron, 59, 4059-4067 (2003)
  • H. Hojo, E. Haginoya, Y. Matsumoto, Y. Nakahara, K. Nabeshima, B. P. Toole and Y. Watanabe The first synthesis of peptide thioester carrying N-linked core pentasaccharide through modified Fmoc thioester preparation: synthesis of an N-glycosylated Ig domain of emmprin. Tetrahedron Lett., 44, 2961-2964 (2003).
  • Y. Takano, M. Habiro, M. Someya, H. Hojo and Y. Nakahara Preparation of core 2 type tetrasaccharide carrying decapeptide by benzyl protection-based solid-phase synthesis strategy. Tetrahedron Lett., 43, 8395-8399 (2002).
  • Ohlenschlager O, Hojo H, Ramachandran R, Gorlach M, Haris PI Three-dimensional structure of the s4-s5 segment of the shaker potassium channel. Biophys. J, 82, 2995-3002 (2002).
  • J. Watabe, L. Singh, Y. Nakahara, Y. Ito, H. Hojo, and Y. Nakahara Synthesis of Core-class 2 O-linked Glycopeptides: a Benzyl-protected Tetrasaccharyl Serine and its Derivative Carrying a Hydrophobic Cholestanyl Group. Biosci. Biotechnol. Biochem., 66, 1904-1914 (2002) .
  • T. Ichiyanagi, M. Takatani, K. Sakamoto, Y. Nakahara, Y. Ito, H. Hojo and Y. Nakahara Synthesis of mucin-type glycopeptide (bhCG 130-145) by on-resin fragment condensation of the glycopeptide segments carrying unmasked oligosaccharides. Tetrahedron Lett., 43, 3297-3300 (2002).
  • A. Ishii, H. Hojo, Y. Nakahara, Y. Ito, and Y. Nakahara Silyl Linker-based Approach to the Solid-phase Synthesis of Fmoc Glycopeptide Thioesters. Biosci. Biotechnol. Biochem., 66, 225-232 (2002)
  • Y. Hamanaka, M. Nakashima, M. Ito, A. Wada, H. Kurazono, H. Hojo, Y. Nakahara, S. Kohno, T. Hirayama and I. Sekine Expression of human ?-defensin-2 (hBD-2) in Helicobacter pylori-induced gastritis: antibacterial effect of hBD-2 against H. pylori. Gut., 49, 481-487 (2001).
  • K. Ogushi, A. Wada, T. Niidome, N. Mori, K. Oishi, T. Nagatake, A. Takahashi, H. Asakura, S. Makino, H. Hojo, Y. Nakahara, M. Ohsaki, T. Hatakeyama, H. Aoyagi, H. Kurazono, J. Moss and T. Hirayama Salmonella enteritidis Flic (Flagella Filament Protein) Induces Human ?-Defensin-2 mRNA Production by Caco-2 Cells. J. Biol. Chem., 276, 30521-30526 (2001)
  • Y. Nakahara, S. Ando, Y. Ito, H. Hojo and Y. Nakahara New allyl ester linker and solid-phase block synthesis of the serglycin core region. Biosci. Biotechnol. Biochem., 65, 1358-1368 (2001)
  • A. Wada, K. Ogushi, T. Kimura, H. Hojo, N. Mori, S. Suzuki, A. Kumatori, M. Se, Y. Nakahara, M. Nakamura, J. Moss and T. Hirayama Helicobacter pylori-mediated transcriptional regulation of the human b-defensin 2 gene requires NF-kB. Cell Microbiol, 3, 115-123 (2001).
  • K. Takahashi, T. Noguti, H. Hojo,T. Ohkubo and M. Go Conformational characterization of Designed Minibarnase. Biopolymers, 58, 260-267 (2001)
  • H. Hojo, J. Watabe, Y. Nakahara, Y. Nakahara, Y. Ito, K. Nabeshima and B.P. Toole Synthesis of the extracellular Ig domain I of Emmprin carrying a chitobiose unit. Tetrahedron Lett., 42, 3001-3004 (2001)
  • Y. Nakahara, S. Ando, M. Itakura, N. Kumabe, H. Hojo, Y. Ito and Y. Nakahara Solid-phase synthesis ofserglycine glycopeptides on a new allyl ester linker. Tetrahedron Lett., 41, 6489-6493 (2000).
  • A. Ishii, H. Hojo, A. Kobayashi, K. Nakamura, Y. Nakahara, Y. Ito and Y. Nakahara A Facile Silyl Linker Strategy for the Solid-Phase Synthesis of Protected Glycopeptide: Synthesis of an N-Terminal Fragment of IL-2 (1-10). Tetrahedron, 56, 6235-6243 (2000).
  • A Wada, N. Mori, K. Onishi, H. Hojo, Y. Nakahara, Y. Hamanaka, M. Nagashima, I. Sekine, K. Ogushi, T. Niidome, T. Nagatake, J. Moss and T. Hirayama Induction of human ?-defensin-2 mRNA Expression by Helicobacter pylori in Human Gastric Cell Line MKN45 Cells on cag Pathogenicity Island. Biochem. Biophys. Res. Commun., 263, 770-774 (1999).
  • K. Takahashi, T. Noguti, H. Hojo, K. Yamauchi, M. Kinoshita, S. Aimoto, T. Ohkubo and M. Go A mini-protein designed by removing a module from barnase: molecular modeling and NMR measurements of the conformation. Protein Engineering, 12, 673-679 (1999).
  • H. Hojo, Y. Akamatsu, K. Yamauchi, M. Kinoshita, S. Miki and Y. Nakamura Synthesis and Structural Characterization of Triple-Helical Peptides Which Mimic the Ligand Binding Site of the Human Macrophage Scavenger Receptor. Tetrahedron, 53, 14263-14274 (1997).
  • S. Futaki, K. Sogawa, J. Maruyama, T. Asahara, M. Niwa and H. Hojo Preparation of Peptide Thioesters using Fmoc Solid-Phase Peptide Synthesis and its Application to the Construction of a Template-Assembled Synthetic Protein (TASP). Tetrahedron Lett., 38, 6237-6240 (1997).
  • S. Miki, S. Tsukada, Y. Nakamura, S. Aimoto, H. Hojo, B. Sato, M. Yamamoto and Y. Miki Functional and Possible Physical Association of Scavenger Receptor with Cytoplasmic Tyrosine Kinase Lyn in Monocytic THP-1-Derived Macrophages. FEBS Letters, 399, 241-244 (1996).
  • H. Hojo, T. Kojima, K. Yamauchi and M. Kinoshita Synthesis and Liposome-Formation of a Thermostable Lipid Bearing Cell Adhesion Peptide Sequence. Tetrahedron Lett., 37, 7391-7394 (1996) .
  • Y. Kakuta, H. Hojo, S. Aimoto, I. Tanaka and K. Hikichi 13C-NMR Relaxation Study on Mobility of the DNA-Binding Arm of HU. J. Biochem., 116, 1153-1155 (1994).
  • H. Mihara, S. Maeda, R. Kurosaki, S. Ueno, S. Sakamoto, T. Niidome, H. Hojo, S. Aimoto and H. Aoyagi Peptide Synthesis Mediated by Thiolsubtilisin Using Peptide Thioester as Building Block. Chem. Lett., 397-398 (1995)
  • K. Ogata, S. Morikawa, H. Nakamura, H. Hojo, S. Yoshimura, R. Zhang, S. Aimoto, Y. Ametani, Z. Hirata, A. Sarai, S. Ishii and Y. Nishimura Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb. Nature structural biology, 2, 309-320 (1995).
  • H. Hojo, S. Yoshimura, M. Go and S. Aimoto Preparation of S-Protected Cysteine-Containing Peptide Thioester and Its Use for the Synthesis of the Barnase-Like Domain in DNA-Directed RNA Polymerase II of Saccharomyces cerevisiae. Bull. Chem. Soc. Jpn., 68, 330-336 (1995).
  • R.H. Zhang, X. Xu, Y. Q. Tang, H. Hojo, S. Aimoto Synthesis of C-Myb Protein (38-89)-NH2 Using a Partially Protected Peptide Thioester. Science in China Series B-Chemistry Life Sciences & Earth Sciences, 37, 932-939 (1994).
  • H. Hojo and S. Aimoto Synthesis of Barnase Site-Specifically Labelled with Two 13C Atoms Using Partially Protected Peptide Thioester Building Blocks. Bull. Chem. Soc. Jpn., 66, 3004-3008 (1993).
  • H. Hojo, Y. D. Kwon, Y. Kakuta, S. Tsuda, I. Tanaka, K. Hikichi and S. Aimoto Development of a Linker with an Enhanced Stability for the Preparation of Peptide Thioesters and Its Application to the Synthesis of a Stable Isotope-Labelled HU-Type DNA-Binding Protein. Bull. Chem. Soc. Jpn., 66, 2700-2706 (1993).
  • Y. D. Kwon, R. H. Zhang, M. P. Bemquerer, M. Tominaga, H. Hojo and S. Aimoto Preparation of Partially Protected Peptide Thioesters Containing a Cysteine Residue and Their Segment Condensation. Chem. Lett., 881-884 (1993).
  • Y. Nakamura, M. Takeda, S. Aimoto, H. Hojo, T. Takao, Y. Shimonishi, S. Hariguchi and T. Nishimura Assembly Regulatory Domain of Glial Fibrillary Acidic Protein. J. Biol. Chem., 267, 23269-23274 (1992).
  • H. Hojo and S. Aimoto Protein Synthesis Using S-Alkyl Thioester of Partially Protected Peptide Segments. Bull. Chem. Soc. Jpn., 65, 3055-3063 (1992).
  • K. Ogata, H. Hojo, S. Aimoto, T. Nakai, H. Nakamura, A. Sarai, S. Ishii and Y. Nishimura Solution Structure of a DNA-Binding Unit of Myb: a Helix-Turn-Helix-Related Motif with Conserved Tryptophans Forming a Hydrophobic Core. Proc. Natl. Acad. Sci. USA, 89, 6428-6432 (1992).
  • O. B. Peersen, S. Yoshimura, H. Hojo, S. Aimoto and S. O. Smith Rotational Resonance NMR Measurement of Internuclear Distances in an ?-Helical Peptide. J. Am. Chem. Soc., 114, 4332-4335 (1992).
  • Y. Kobayashi, A. Sato, H. Takashima, H. Tamaoki, S. Nishimura, Y. Kyogoku, K. Ikenaka, T. Kondo, K. Mikoshiba, H. Hojo, S. Aimoto and L. Moroder A New a-Helical Motif in Membrane Active Peptides. Neurochem. Int., 18, 525-534 (1991).
  • Y. Ohta, H. Hojo, S. Aimoto, T. Kobayashi, X. Zhu, F. Jordan and M. Inouye Pro-Peptide as an Intermolecular Chaperone: Renaturation of Denatured Subtilisin E with a Synthetic Pro-Peptide. Molecular Microbiology, 5, 1507-1510 (1991).
  • H. Hojo and S. Aimoto Polypeptide Synthesis Using the S-Alkyl Thioester of a Partially Protected Peptide Segment. Synthesis of the DNA-Binding Domain of c-Myb Protein(142-193)-NH2. Bull. Chem. Soc. Jpn., 64, 111-117 (1991).
  • S. Aimoto, H. Hojo and C. Takasaki Studies on the Disulfide Bridges of Sarafotoxins. Chemical Synthesis of Sarafotoxin S6b and Its Homologue with Different Disulfide Bridges. Biochemistry International, 21 (6), 1051-1057 (1990).
  • T. Kondo, K. Ikenaka, H. Kato, K. Ito, S. Aimoto, H. Hojo and K. Mikoshiba Long-Term Enhancement of Synaptic Transmission by Synthetic Mast Cell Degranulating Peptide and Its Localization of Binding Sites in Hippocampus. Neuroscience Research, 8, 147-157 (1990).
  • T. Ide, T. Taguchi, T. Morita, M. Sato, K. Ikenaka, S. Aimoto, T. Kondo, H. Hojo, M. Kasai and K. Mikoshiba Mast Cell Degranulating Peptide Forms Voltage Gated and Cation-Selective Channels in Lipid Bilayers. Biochem. Biophys. Res. Commun., 163, 155-160 (1989).
  • S. Aimoto, N. Mizoguchi, H. Hojo and S. Yoshimura Development of a Facile Method for Polypeptide Synthesis. Synthesis of Bovine Pancreatic Trypsin Inhibitor (BPTI). Bull. Chem. Soc. Jpn., 62, 524-531 (1989) .
  • 総説 H. Hojo, H. Katayama, Y. Nakahara Progress in the ligation chemistry for glycoprotein synthesis. Trends Glycosci. Glycotechnol., 22, 269-279 (2010) .
  • H. Hojo, Y. Nakahara Recent progress in the field of glycopeptide synthesis. Biopolymers: Peptide Science, 88, 308-324 (2007).
  • H. Hojo, Y. Nakahara Recent Progress in the Solid-phase Synthesis of Glycopeptide. Current Protein and Peptide Science, 1, 23-48 (2000)