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PUBLICATION LIST for T. ARIMORI（有森貴夫） Aug 2025
- Structural insights into cancer cell-specific recognition by H2Mab-214, a novel anti-HER2 antibody
- Arimori T#
SPring-8/SACLA Research Frontiers 2024 (2025) :26-27 [Link]
- Neutron and time-resolved X-ray crystallography reveal the substrate recognition and catalytic mechanism of human Nudix hydrolase MTH1
- Hirata K, Fujimiya K, Ostermann A, Schrader TE, Hiromoto T, Goto M, Arimori T, Hirano Y, Kusaka K, Tamada T, Nakamura T
Proc Natl Acad Sci U S A. (2025) 122(29):e2510085122 [Pubmed]
- Preferential tumor targeting of HER2 by iPSC-derived CAR T cells engineered to overcome multiple barriers to solid tumor efficacy
- Hosking MP, Shirinbak S, Omilusik K, Chandra S, Kaneko MK, Gentile A, Yamamoto S, Shrestha B, Grant J, Boyett M, Cardenas D, Keegan H, Ibitokou S, Pavon C, Mizoguchi T, Ihara T, Nakayama D, Abujarour R, Lee TT, Clarke R, Goodridge J, Peralta E, Maeda T, Takagi J, Arimori T, Kato Y, Valamehr B
Cell Stem Cell (2025) 32(7):1087-1101.e4 [Pubmed]
- CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
- Ikeda S, Hasegawa K, Kogue Y, Arimori T, Kawamoto R, Wibowo T, Yaga M, Inada Y, Uehara H, Matsubara M, Tachikawa M, Suga M, Kida S, Shibata K, Tsutsumi K, Fukushima K, Fujita J, Ueda T, Kusakabe S, Hino A, Ichii M, Hirose A, Nakamae H, Hino M, Nakao T, Inoue M, Yoshihara K, Yoshihara S, Ueda S, Tachi T, Kuroda H, Murakami K, Kijima N, Kishima H, Igashira E, Murakami M, Takiuchi T, Kimura T, Hiroshima T, Kimura T, Shintani Y, Imai C, Yusa K, Mori R, Ogino T, Eguchi H, Takeda K, Oji Y, Kumanogoh A, Takagi J, Hosen N
Nat. Cancer (2025) 6(4):595-611 [Pubmed]
- Engineered DPP4 decoy confers broad-spectrum inhibition of MERS-CoV infection
- Nishioka K, Sakai Y#, Motooka D, Yoshikawa NI, Tojo H, Matoba S, Nagata N, Nakaya T, Arimori T#, Hoshino A#
Cell Biomaterials (2025) 1(2):100018 #corresponding authors [Link]
- The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains
- Liu Y, Mori T, Ito Y, Kuroki K, Hayashi S, Kohda D, Shimizu T, Ishida T, Roffler SR, Kaneko MK, Kato Y, Arimori T, Teramoto T, Takemura K, Ishibashi K, Katayama Y, Maenaka K, Kakuta Y, Kitao A, Mori T
Journal of Controlled Release (2025) 380(10):396-403 [Pubmed]
- タンパク質立体構造の乱れを標的とするがん特異的抗HER2抗体
- 有森貴夫
バイオサイエンスとインダストリー (2024) 82(5):470-473
- Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies
- Arimori T#, Mihara E, Suzuki H, Ohishi T, Tanaka T, Kaneko MK, Takagi J, Kato Y#
Structure (2024) 32(5):536-549 #corresponding authors [Pubmed] [関連動画]
- 次世代型Fc融合法による超効率的な疾病関連蛋白質の生産
- 有森貴夫、高木淳一
実験医学 (2024) 43(2):82-88
- Deep mutational scanning of whole SARS-CoV-2 spike in an inverted infection system
- Taminishi S, Li S, Higuchi Y, Kirita Y, Motooka D, Ozaki Y, Arimori T, Ikemura N, Itoh Y, Matoba S, Okamoto T, Takagi J, Standley DM, Hoshino A
bioRxiv (2023) [Link]
- Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
- Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, Eerden F, Tulyeu J, Liu Y, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K
Science Immunology (2023) 8(81):eadc9324 [Pubmed]
- Structural basis for neutralization of SARS-CoV-2 Omicron variant using engineered ACE2 decoy
- Arimori T# and Takagi J
SPring-8/SACLA Research Frontiers 2022 (2023) :22-23 [Link]
- Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy
- Zhang Q, Miyamoto A, Watanabe S, Arimori T, Sakai M, Tomisaki M, Kiuchi T, Takagi J, Watanabe N
Cell Reports Methods (2022) 2(10):100301 [Pubmed]
- De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function
- Sugano-Nakamura N, Matoba K, Hirose M, Bashiruddin NK, Matsunaga Y, Yamashita K, Hirata K, Yamamoto M, Arimori T, Suga H, Takagi J
Structure (2022) 30(10):1411-1423.e4 [Pubmed]
- Engineering ACE2 decoy receptors to combat viral escapability
- Arimori T, Ikemura N, Okamoto T, Takagi J, Standley DM, Hoshino A
Trends Pharmacol Sci. (2022) 43(10):838-851 [Pubmed]
- An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo
- Ikemura N*, Taminishi S*, Inaba T*, Arimori T*, Motooka D*, Katoh K*, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T, Takagi J, Hoshino A
Sci Transl Med. (2022) eabn7737 *equally contributed [Pubmed]
- Engineered ACE2 counteracts vaccine-evading SARS-CoV-2 Omicron variant
- Ikemura N*, Taminishi S*, Inaba T*, Arimori T*, Motooka D*, Katoh K*, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T, Takagi J, Hoshino A
bioRxiv (2022) *equally contributed [Link]
- Crystal structure of engineered ACE2 complexed with SARS-CoV-2 Spike RBD
- Arimori T# and Takagi J
SPring-8/SACLA Research Frontiers 2021 (2022) :20-21 [Link]
- Structural mechanism of laminin recognition by integrin
- Arimori T, Miyazaki N, Mihara E, Takizawa M, Taniguchi Y, Cabañas C, Sekiguchi K, Takagi J
Nat. Commun. (2021) 12(1):4012 [Pubmed]
- 指向性進化法による高親和性ACE2創出とCOVID-19創薬展開
- 星野温、有森貴夫
医学のあゆみ (2021) 278(6):588-595
- タンパク質結晶化に応用可能な新規小型抗体フォーマットFv-claspの開発
- 有森貴夫
日本結晶学会誌 (2021) 63:113-120 [Link]
- Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
- Higuchi Y*, Suzuki T*, Arimori T*, Ikemura N*, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T, Takagi J, Hoshino A
Nat. Commun. (2021) 12(1):3802 *equally contributed [Pubmed]
- Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues
- Kobashigawa Y, Ohara T, Morita K, Toyota Y, Nakamura T, Kotani S, Arimori T, Yamauchi S, Liu C, Kitazaki M, Wakeyama-Miyazaki Y, Suwa Y, Uchida-Kamekura M, Fukuda N, Sato T, Nakajima M, Takagi J, Yamagata Y, Morioka H
J. Biochem. (2021) 170(3):379-387 [Pubmed]
- Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
- Mihara E, Watanabe S, Bashiruddin NK, Nakamura N, Matoba K, Sano Y, Maini R, Yin Y, Sakai K, Arimori T, Matsumoto K, Suga H, Takagi J
Nat. Commun. (2021) 12(1):1543 [Pubmed]
- A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems
- Sato N, Yogo R, Yanaka S, Martel A, Porcar L, Morishima K, Inoue R, Tominaga T, Arimori T, Takagi J, Sugiyama M, Kato K
J. Biochem. (2021) 169(6):701-708 [Pubmed]
- High affinity modified ACE2 receptors protect from SARS-CoV-2 infection in hamsters
- Higuchi Y*, Suzuki T*, Arimori T*, Ikemura N*, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T, Takagi J, Hoshino A
bioRxiv (2020) *equally contributed [Link]
- Site-specific epitope insertion into recombinant proteins using the MAP tag system
- Wakasa A, Kaneko MK, Kato Y, Takagi J, Arimori T#
J. Biochem. (2020) 168(4):375-384 #corresponding author [Pubmed]
- Crystal structure of mammalian Wnt-frizzled complex
- Hirai H, Matoba K, Mihara E, Arimori T, Takagi J
Nat. Struct. Mol. Biol. (2019) 26(5):372-379 [Pubmed]
- X-ray Structure Analysis of Human Oxidized Nucleotide Hydrolase MTH1 using Crystals Obtained under Microgravity
- Nakamura T, Hirata K, Fujimiya K, Chirifu M, Arimori T, Tamada T, Ikemizu S, Yamagata Y
Int. J. Microgravity Sci. Appl. (2019) 36:360103 [Link]
- ラミニン3量体の立体構造解析とインテグリンとの相互作用
- 瀧沢士、有森貴夫、谿口征雅、高木淳一、関口清俊
生物物理 (2019) 59(2):091-093 [Link]
- Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy
- Brown ZP, Arimori T, Iwasaki K, Takagi J
J Struct Biol. (2018) 201(3):247-251 [Pubmed]
- 小型抗体の作製技術（特集 次世代抗体医薬の衝撃）
- 有森貴夫、高木淳一
実験医学 (2018) 36:1849-1853
- 新規小型抗体「Fv-clasp」の開発
- 有森貴夫、高木淳一
バイオサイエンスとバイオインダストリー (2018) 76:132-133
- Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
- Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H
Nature (2017) 552(7683):101-105 [Pubmed]
- Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus
- Sakakibara S, Arimori T, Yamashita K, Jinzai H, Motooka D, Nakamura S, Li S, Takeda K, Katayama J, El Hussien MA, Narazaki M, Tanaka T, Standley DM, Takagi J, Kikutani H
Sci. Rep. (2017) 7(1):16428 [Pubmed]
- Fv-clasp: An artificially designed small antibody fragment with improved production compatibility, stability, and crystallizability
- Arimori T, Kitago Y, Umitsu M, Fujii Y, Asaki R, Tamura-Kawakami K, Takagi J
Structure (2017) 25(10):1611-1622 [Pubmed]
- Mechanistic basis for the recognition of laminin-511 by α6β1 integrin
- Takizawa M*, Arimori T*, Taniguchi Y*, Kitago Y, Yamashita E, Takagi J, Sekiguchi K
Science Advances (2017) 3(9):e1701497 [Pubmed]
- Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
- Waz S, Nakamura T, Hirata K, Koga-Ogawa Y, Chirifu M, Arimori T, Tamada T, Ikemizu S, Nakabeppu Y, Yamagata Y
J. Biol. Chem. (2017) 292(7):2785-2794 [Pubmed]
- 結晶構造から読み解く PA タグシステムの原理とタンパク質ループ構造への挿入
- 松永幸子、有森貴夫、高木淳一
和光純薬時報 (2017) 85(1):2-4 [Link]
- Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state
- Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kato-Kaneko M, Kato Y, Takagi J
J. Cell Sci. (2016) 129(7):1512-1522 [Pubmed]
- GHファミリー23に属する新奇キチナーゼの構造と機能
- 有森貴夫、玉田太郎
日本結晶学会誌 (2014) 56:201-206 [Link]
- Crystal structure of endo-1,4-β-glucanase from Eisenia fetida
- Arimori T, Ito A, Nakazawa M, Ueda M, Tamada T
J. Synchrotron Radiat. (2013) 20(Pt 6):884-889 [Pubmed]
- Crystal structures of the catalytic domain of a novel glycohydrolase family 23 chitinase from Ralstonia sp. A-471 reveals a unique arrangement of the catalytic residues for inverting chitin hydrolysis
- Arimori T, Kawamoto N, Okazaki N, Nakazawa M, Miyatake K, Shinya S, Fukamizo T, Ueda M, Tamada T
J. Biol. Chem. (2013) 288(26):18696-18706 [Pubmed]
- Mechanistic insight into hydrolysis of oxidized nucleotide diphosphates by human NUDT5
- Arimori T, Yamagata Y
Fukuoka Acta Medica (2011) 102(11):303－312 [Pubmed]
- Diverse Substrate Recognition and Hydrolysis Mechanisms of Human NUDT5
- Arimori T, Tamaoki H, Nakamura T, Kamiya H, Ikemizu S, Takagi Y, Ishibashi T, Harashima H, Sekiguchi M, Yamagata Y
Nucleic Acids Research (2011) 39(20):8972-8983 [Pubmed]
- Crystallization and preliminary X-ray diffraction studies of the catalytic domain of novel chitin-ase, a member of GH family 23, from the moderately thermophilic bacterium Ralstonia sp. A-471
- Okazaki N, Arimori T, Nakazawa M, Miyatake K, Kuroki R, Ueda M, Tamada T
Acta Crystallogr Sect F Struct Biol Cryst Commun. (2011) 67(Pt 4):494-497 [Pubmed]
- The crystal structure of the green tea polyphenol (-)-epigallocatechin gallate-transthyretin complex reveals a novel binding site distinct from the thyroxine binding site
- Miyata M, Sato T, Kugimiya M, Sho M, Nakamura T, Ikemizu S, Chirifu M, Mizuguchi M, Nabeshima Y, Suwa Y, Morioka H, Arimori T, Suico MA, Shuto T, Sako Y, Momohara M, Koga T, Morino-Koga S, Yamagata Y, Kai H
Biochemistry (2010) 49(29):6104-6114 [Pubmed]
- NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity
- Kamiya H, Hori M, Arimori T, Sekiguchi M, Yamagata Y, Harashima H
DNA repair (2009) 8(10):1250-1254 [Pubmed]
受賞
- 6. 大阪大学賞若手教員部門 (2022)
- 5. 日本結晶学会 進歩賞 (2020)
- 4. 第15回日本蛋白質科学会年会 若手奨励賞 (2015)
- 3. 第9回次世代を担う若手のためのフィジカル・ファーマフォーラム 若手研究者奨励賞 (2011)
- 2. 第26回日本薬学会九州支部大会 優秀発表賞 (2009)
- 1. 第8回日本蛋白質科学会年会 ポスター賞 (2008)
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