(for reprint request, send e-mail to J. Takagi)
[2025]
- CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant
- Ikeda S, Hasegawa K, Kogue Y, Arimori T, Kawamoto R, Wibowo T, Yaga M, Inada Y, Uehara H, Matsubara M, Tachikawa M, Suga M, Kida S, Shibata K, Tsutsumi K, Fukushima K, Fujita J, Ueda T, Kusakabe S, Hino A, Ichii M, Hirose A, Nakamae H, Hino M, Nakao T, Inoue M, Yoshihara K, Yoshihara S, Ueda S, Tachi T, Kuroda H, Murakami K, Kijima N, Kishima H, Igashira E, Murakami M, Takiuchi T, Kimura T, Hiroshima T, Kimura T, Shintani Y, Imai C, Yusa K, Mori R, Ogino T, Eguchi H, Takeda K, Oji Y, Kumanogoh A, Takagi J, Hosen N.
Nature Cancer (2025) in press [Pubmed]
- Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement
- Chida S, Chiba T, Uchida Y, Matsushima T, Kurimoto R, Miyazaki T, Yagasaki L, Nakamura S, Mihara E, Takagi J, Moriyama K, Asahara H.
J. Bone Miner. Metab. (2025) in press [Pubmed]
[2024]
- Development of a new antibody drug to treat congenital tooth agenesis
- Takahashi K, Kiso H, Mihara E, Takagi J, Tokita Y, Murashima-Suginami A.
J. Oral Biosci. (2024) 66(4):1-9 [Pubmed]
- A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model
- Rojas-Chaverra NM, Imamura R, Sato H, Passioura T, Mihara E, Nishimura T, Takagi J, Suga H, Matsumoto K, Sakai K.
iScience (2024) 27(8):110426 [Pubmed]
- PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
- Franzolin G, Brundu S, Cojocaru CF, Curatolo A, Ponzo M, Mastrantonio R, Mihara E, Kumanogoh A, Suga H, Takagi J, Tamagnone L, Giraudo E.
Cancer Immunol Res. (2024) 12(9):1286-1301 [Pubmed]
- Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies
- Arimori T, Mihara E, Suzuki H, Ohishi T, Tanaka T, Kaneko MK, Takagi J, Kato Y.
Structure (2024) 32(5):536-549 [Pubmed]
- C-terminal amino acids in the type I transmembrane domain of L-type lectin VIP36 affect γ-secretase susceptibility
- Hua Z, Watanabe R, Fukunaga T, Matsui Y, Matsuoka M, Yamaguchi S, Tanabe S, Yamamoto M, Kawakami KT, Takagi J, Kajita M, Futai E, Shirakabe K.
Biochem Biophys Res Commun. (2024) 12:696:149504 [Pubmed]
- Anti-α6β4 integrin autoantibodies inhibit the binding of laminins to α6β4 integrin in patients with pemphigoid and affect the gastrointestinal tract
- Arase N, Sasaoka Y, Narita J, Kiyohara E, Hashimoto K, Shinzaki S, Nojima S, Takagi J, Fujimoto M.
J Eur Acad Dermatol Venereol. (2024) 38(2):404-412 [Pubmed]
[2023]
- An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models
- Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa J, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T.
Sci Transl Med. (2023) 15(711):eadi2623 [Pubmed]
- Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
- Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, Eerden F, Tulyeu J, Liu Y, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, Suzuki K.
Science Immunology (2023) 8(81):eadc9324 [Pubmed]
- Wnt 2022 EMBO | the Company of Biologists workshop and Yamada conference
- Kikuchi A, Takagi J, Takada S, Ishitani T, Minami Y.
Genes to Cells (2023) 28(4):249-257 [Pubmed]
- Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein
- Kuhn CC, Basnet N, Bodakuntla S, Alvarez-Brecht P, Nichols S, Martinez-Sanchez A, Agostini L, Soh YM, Takagi J, Biertümpfel C, Mizuno N.
Nat Commun. (2023) 14(1):620 [Pubmed]
- Advances in tooth agenesis and tooth regeneration
- Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K.
Regen Ther. (2023) 3:22:160-168 [Pubmed]
[2022]
- Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions
- Sakai K, Sugano-Nakamura N, Mihara E, Rojas-Chaverra NM, Watanabe S, Sato H, Imamura R, Voon DC, Sakai I, Yamasaki C, Tateno C, Shibata M, Suga H, Takagi J, Matsumoto K.
Nat Biomed Eng. (2022) 7(2):164-176 [Pubmed]
- Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy
- Zhang Q, Miyamoto A, Watanabe S, Arimori T, Sakai M, Tomisaki M, Kiuchi T, Takagi J, Watanabe N.
Cell Reports Methods (2022) 2(10):100301 [Pubmed]
- Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ3
- Sen S, Spasic A, Sinha A, Wang J, Bush M, Li J, Nešić D, Zhou Y, Angiulli G, Morgan P, Salas-Estrada L, Takagi J, Walz T, Coller BS, Filizola M.
J Chem Inf Model. (2022) 62(22):5607-5621 [Pubmed]
- Hybrid in vitro/in silico analysis of low-affinity protein-protein interactions that regulate signal transduction by Sema6D
- Tanaka T, Ekimoto T, Nagatomo M, Neyazaki M, Shimoji E, Yamane T, Kanagawa S, Oi R, Mihara E, Takagi J, Akashi S, Ikeguchi M, Nogi T.
Protein Sci. (2022) 31(11):e4452 [Pubmed]
- De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function
- Sugano-Nakamura N, Matoba K, Hirose M, Bashiruddin NK, Matsunaga Y, Yamashita K, Hirata K, Yamamoto M, Arimori T, Suga H, Takagi J.
Structure (2022) 30(10):1411-1423.e4 [Pubmed]
- Engineering ACE2 decoy receptors to combat viral escapability
- Arimori T, Ikemura N, Okamoto T, Takagi J, Standley DM, Hoshino A.
Trends Pharmacol Sci. (2022) 43(10):838-851. [Pubmed]
- Functional role of the Frizzled linker domain in the Wnt signaling pathway
- Ko SB, Mihara E, Park Y, Roh K, Kang C, Takagi J, Bang I, Choi HJ.
Commun Biol. (2022) 5(1):421. [Pubmed]
- An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo
- Ikemura N, Taminishi S, Inaba T, Arimori T, Motooka D, Katoh K, Kirita Y, Higuchi Y, Li S, Suzuki T, Itoh Y, Ozaki Y, Nakamura S, Matoba S, Standley DM, Okamoto T, Takagi J, Hoshino A.
Sci Transl Med. (2022) :eabn7737. [Pubmed]
- Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain
- Hasegawa K, Ikeda S, Yaga M, Watanabe K, Urakawa R, Iehara A, Iwai M, Hashiguchi S, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Yoshihara S, Manabe M, Ichihara H, Mugitani A, Aoyama Y, Nakao T, Hirose A, Hino M, Ueda S, Takenaka K, Masuko T, Akashi K, Maruno T, Uchiyama S, Takamatsu S, Wada N, Morii E, Nagamori S, Motooka D, Kanai Y, Oji Y, Nakagawa T, Kijima N, Kishima H, Ikeda A, Ogino T, Shintani Y, Kubo T, Mihara E, Yusa K, Sugiyama H, Takagi J, Miyoshi E, Kumanogoh A, Hosen N.
Sci Transl Med. (2022) 14(632):eaax7706. [Pubmed]
[2021]
- Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor-induced bullous pemphigoid
- Yamashita C, Arase N, Higuchi S, Arase H, Takagi J, Nojima S, Tanemura A, Fujimoto M.
JAAD Case Rep. (2021) 20:65-68. [Pubmed]
- De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist
- Komatsu Y, Terasaka N, Sakai K, Mihara E, Wakabayashi R, Matsumoto K, Hilvert D, Takagi J, Suga H.
iScience (2021) 24(11):103302. [Pubmed]
- Structural mechanism of laminin recognition by integrin
- Arimori T, Miyazaki N, Mihara E, Takizawa M, Taniguchi Y, Cabañas C, Sekiguchi K, Takagi J.
Nat. Commun. (2021) 12(1):4012. [Pubmed]
- Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2
- Higuchi Y, Suzuki T, Arimori T, Ikemura N, Mihara E, Kirita Y, Ohgitani E, Mazda O, Motooka D, Nakamura S, Sakai Y, Itoh Y, Sugihara F, Matsuura Y, Matoba S, Okamoto T, Takagi J, Hoshino A.
Nat. Commun. (2021) 12(1):3802. [Pubmed]
- Structural insights into integrin α5β1 opening by fibronectin ligand
- Schumacher S, Dedden D, Nunez RV, Matoba K, Takagi J, Biertümpfel C, Mizuno N.
Sci. Adv. (2021) 7(19):eabe9716. [Pubmed]
- Molecular recognition of a single-chain Fv antibody specific for GA-pyridine, an advanced glycation end-product (AGE), elucidated using biophysical techniques and synthetic antigen analogues
- Kobashigawa Y, Ohara T, Morita K, Toyota Y, Nakamura T, Kotani S, Arimori T, Yamauchi S, Liu C, Kitazaki M, Wakeyama-Miyazaki Y, Suwa Y, Uchida-Kamekura M, Fukuda N, Sato T, Nakajima M, Takagi J, Yamagata Y, Morioka H.
J. Biochem. (2021) 170(3):379-387. [Pubmed]
- Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
- Mihara E, Watanabe S, Bashiruddin NK, Nakamura N, Matoba K, Sano Y, Maini R, Yin Y, Sakai K, Arimori T, Matsumoto K, Suga H, Takagi J.
Nat. Commun. (2021) 12(1):1543. [Pubmed]
- Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling
- Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K.
Sci. Adv. (2021) 7(7):eabf1798. [Pubmed]
- A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems
- Sato N, Yogo R, Yanaka S, Martel A, Porcar L, Morishima K, Inoue R, Tominaga T, Arimori T, Takagi J, Sugiyama M, Kato K.
J. Biochem. (2021) 169(6):701-708. [Pubmed]
[2020]
- Structural studies of reelin N-terminal region provides insights into a unique structural arrangement and functional multimerization
- Nagae M, Suzuki K, Yasui N, Nogi T, Kohno T, Hattori M, Takagi J.
J. Biochem. (2020) 169(5):555-564. [Pubmed]
- Development of cyclic peptides with potent in vivo osteogenic activity through RaPID-based affinity maturation
- Bashiruddin NK, Hayashi M, Nagano M, Wu Y, Matsunaga Y, Takagi J, Nakashima T, Suga H.
Proc. Natl. Acad. Sci. U S A. (2020) 117(49):31070-31077. [Pubmed]
- Dissection of α4β7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β7 antibodies
- Sato T, Ishihara S, Marui R, Takagi J, Katagiri K.
Sci. Rep. (2020) 10(1):13221. [Pubmed]
- Negatively charged amino acids in the stalk region of membrane proteins reduce ectodomain shedding
- Iwagishi R, Tanaka R, Seto M, Takagi T, Norioka N, Ueyama T, Kawamura T, Takagi J, Ogawa Y, and Shirakabe K.
J. Biol. Chem. (2020) 295(35):12343-12352. [Pubmed]
- Site-specific epitope insertion into recombinant proteins using the MAP tag system
- Wakasa A, Kaneko MK, Kato Y, Takagi J, and Arimori T.
J. Biochem. (2020) 168(4):375-384. [Pubmed]
- Macrocyclic Peptides that Inhibit Wnt Signalling via interaction with Wnt3a
- Otero-Ramirez ME, Matoba K, Mihara E, Passioura T, Takagi J, and Suga H.
RSC Chemical Biol. (2020) 1, 26-34.
- The constitutive high affinity Met binding site in the kringle domain is dispensable for the signaling activity of hepatocyte growth factor
- Umitsu M, Sakai K, Tamura-Kawakami K, Matsumoto K, Takagi J.
J Biochem. (2020) 167(6):577-586. [Pubmed]
[2019]
- Novel Pure αVβ3 Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations
- Li J, Fukase Y, Shang Y, Zou W, Munoz-Felix JM, Buitrago L, van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA, Coller BS.
ACS Pharmacol. Transl. Sci (2019) 2, 387-401. [Pubmed]
- Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer
- Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K.
Cancer Sci. (2019) 110(10): 3340-3349. [Pubmed]
- Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach
- Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K.
Int J Mol Sci. (2019) 20(12). pii: E2955. [Pubmed]
- Crystal structure of mammalian Wnt-frizzled complex
- Hirai H, Matoba K, Mihara E, Arimori T, and Junichi Takagi J
Nature Struct. Mol. Biol. (2019) 26(5):372-379. [Pubmed]
- Structural basis of sarco/endoplasmic reticulum Ca2+-ATPase 2b regulation via transmembrane helix interplay
- Inoue M, Sakuta N, Watanabe S, Yoshikaie K, Tanaka Y, Ushioda R, Kato Y, Takagi J, Tsukazaki T, Nagata K, and Inaba K
Cell Rep. (2019) 27(4):1221-1230.e3. [Pubmed]
- Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
- Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Yano S, Shibata M, Suga H, and Matsumoto K
Nature Chem. Biol. (2019) 15 (6):598-606. [Pubmed]
- Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2
- Nagamura R, Fukuda M, Kawamoto A, Matoba K, Naoshi Dohmae N, Ishitani R, Takagi J, and Nureki O
Acta Crystallogr. F (2019) 75(Pt 5):348-358. [Pubmed]
- Advances in domain and subunit localization technology for electron microscopy
- Brown ZP, Takagi J.
Biophys Rev. (2019) 11(2):149-155. [Pubmed]
[2018]
- The PA Ttag: A versatile peptide tagging system in the era of integrative structural biology
- Brown ZP, Takagi J.
Adv Exp Med Biol. (2018) 1105:59-76. [Pubmed]
- Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
- Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, Morioka T, Umitsu M, Takagi J, Suga H, and Matsumoto K.
Sci Rep. (2018) 8(1):16492. [Pubmed]
- Off-axis rotor in Enterococcus hirae V-ATPase visualized by Zernike phase plate single-particle cryo-electron microscopy
- Tsunoda J, Song C, Imai FL, Takagi J, Ueno H, Murata T, Iino R, and Murata K.
Sci Rep. (2018) 8(1):15632. [Pubmed]
- Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
- Nagae M, Kizuka Y, Mihara E, Kitago Y, Hanashima S, Ito Y, Takagi J, Taniguchi N, and Yamaguchi Y.
Nat Commun. (2018) 9(1): 3380. [Pubmed]
- Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization
- Kang S, Nakanishi Y, Kioi Y, Okuzaki D, Kimura T, Takamatsu H, Koyama S, Nojima S, Nishide M, Hayama Y, Kinehara Y, Kato Y, Nakatani T, Shimogori T, Takagi J, Toyofuku T, and Kumanogoh A.
Nature Immunology (2018) 19 (6): 561-570. [Pubmed]
- Facile synthesis of dimeric thioether-macrocyclic peptides with antibody-like affinity against Plexin-B1
- Bashiruddin N, Matsunaga Y, Nagano M, Takagi J, and Suga H.
Bioconjug Chem. (2018) 29(6): 1847-1851. [Pubmed]
- Systematic survey of conformational states in 1 and 4 integrins by negative-stain electron microscopy
- Miyazaki N, Iwasaki K, and Takagi J.
J. Cell Sci. (2018) 131(10): jcs.216754. [Pubmed]
- Yeast inner-subunit PA-NZ-1 labeling strategy for accurate subunit identification in a macromolecular complex through cryo-EM analysis
- Wang H, Han W, Takagi J, and Cong Y.
J. Mol. Biol. (2018) 430 (10), 1417-1425. [Pubmed]
- Foreword to 'Multiscale structural biology: biophysical principles and mechanisms underlying the action of bio-nanomachines', a special issue in Honour of Fumio Arisaka's 70th birthday
- Hall D, Takagi J, and Nakamura H.
Biophys. Rev. (2018) 10(2):105-129. [Pubmed]
- An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system
- Tabata S, Kitago Y, Fujii Y, Mihara E, Tamura-Kawakami K, Norioka N, Takahashi K, Kaneko MK, Kato Y, and Takagi J.
Protein Expr Purif. (2018) 147, 94-99. [Pubmed]
- Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression
- Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, Ohta Y, Matano M, Nanki K, Kawasaki K, Takahashi S, Sugimoto S, Iwasaki E, Takagi J, Itoi T, Kitago M, Kitagawa Y, Kanai T, and Sato T.
Cell Stem Cell (2018) 22(3), 454-467. [Pubmed]
- Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy
- Brown ZP, Arimori T, Iwasaki K, and Takagi J.
J. Struct. Biol. (2018) 201, 247-251. [Pubmed]
[2017]
- Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus
- Sakakibara S, Arimori T, Yamashita K, Jinzai H, Motooka D, Nakamura S, Li S, Takeda K, Katayama J, Hussien MAE, Narazaki M, Tanaka T, Standley D, Takagi J, and Kikutani H.
Scientific Rep. (2017) 7: 16428. [Pubmed]
- Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
- Saito F, Hirayasu K, Satoh T, Wang CW3, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, and Arase H.
Nature (2017) 552(7683): 101-105. [Pubmed]
- Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag type IV secretion system
- Koelblen T, Berge C, Cherrier MV, Brillet K, Jimenez-Soto L, Ballut L, Takagi J, Montserret R, Rousselle P, Fischer W, Haas R, Fronzes R, and Terradot L.
FEBS J. (2017) 284(23): 4143-4157. [Pubmed]
- The activated conformation of integrin β7 as a target for multiple myeloma-specific chimeric antigen receptor T-cell therapy
- Hosen N, Matsunaga Y, Hasegawa K, Matsuno H, Nakamura Y, Makita M, Watanabe K, Yoshida M, Satoh K, Morimoto S, Fujiki F, Nakajima H, Nakata J, Nishida S, Tsuboi A, Oka Y, Manabe M, Ichihara H, Aoyama Y, Mugitani A, Nakao T, Hino M, Uchibori R, Ozawa K, Baba Y, Terakura S, Wada N, Morii E, Nishimura J, Takeda K, Oji Y, Sugiyama H, Takagi J, and Kumanogoh A.
Nature Medicine (2017) 23: 1436-1443. [Pubmed]
- Fv-clasp: An artificially designed small antibody fragment with improved production compatibility, stability, and crystallizability
- Arimori, T, Kitago, Y, Umitsu, M, Fujii, Y, Asaki, R, Tamura-Kawakami, K, and Takagi, J.
Structure (2017) 25: 1611-1622. [Pubmed]
- Mechanistic basis for the recognition of laminin-511 by a6b1 integrin
- Takizawa, M, Arimori, T, Taniguchi, Y, Kitago, Y, Yamashita, E, Takagi, J, and Sekiguchi, K.
Science Advances (2017) 3(9): e1701497. [Pubmed]
- Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
- Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N.
Nature Commun. (2017) 8: 15500. [Pubmed]
- Structural basis for perception of diverse chemical substances by T1r taste receptors
- Nuemket N, Yasui N, Kusakabe Y, Nomura Y, Atsumi N, Akiyama S, Nango E, Kato Y, Kaneko M.K, Takagi J, Hosotani M, Yamashita A.
Nature Commun. (2017) 8: 15530. [Pubmed]
- Structural basis for ligand capture and release by the endocytic receptor ApoER2
- Hirai H, Yasui N, Yamashita K, Tabata S, Yamamoto M, Takagi J, Nogi T.
EMBO Rep. (2017) pii: e201643521. [Pubmed]
- Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation
- Shirakabe K, Omura T, Shibagaki Y, Mihara E, Homma K, Kato Y, Yoshimura A, Murakami Y, Takagi J, Hattori S, Ogawa Y.
Scientific Rep. (2017) 7:46174. [Pubmed]
- The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2
- Fukuda S, Kita S, Obata Y, Fujishima Y, Nagao H, Masuda S, Tanaka Y, Nishizawa H, Funahashi T, Takagi J, Maeda N, and Shimomura I.
J Biol Chem. (2017) 292 (19), 7840-7849. [Pubmed]
- 2D hybrid analysis: Approach for building three-dimensional atomic model by electron microscopy image matching
- Matsumoto A, Miyazaki N, Takagi J, and Iwasaki K.
Scientific Rep. (2017) 7(1):377. [Pubmed]
- Conformational freedom of the LRP6 ectodomain is regulated by N-glycosylation and the binding of the Wnt antagonist Dkk1
- Matoba K, Mihara E, Tamura-Kawakami K, Miyazaki N, Maeda S, Hirai H, Thompson S, Iwasaki K, and Takagi J.
Cell Reports (2017) 18, 32-40. [Pubmed]
[2016]
- Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide
- Matsunaga Y, Bashiruddin NK, Kitago Y, Takagi J* and Suga H.
Cell Chem. Biol. (2016) 23:1341-1350. [Pubmed]
- Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies
- Umitsu M, Ogasawara S, Sakai K, Kaneko M, Asaki R, Tamura-Kawakami K, Kato Y, Matsumoto K, and Takagi J.
Scientific Rep. (2016) 9 (6):33149. [Pubmed]
- Redox-assisted regulation of Ca2+ homeostasis in the endoplasmic reticulum by ERdj5
- Ushioda R, Miyamoto A, Inoue M, Watanabe S, Okumura M, Maegawa K, Uegaki K, Fujii S, Fukuda Y, Umitsu M, Takagi J, Inaba K, Mikoshiba K, and Nagata K.
Proc. Natl. Acad. Sci. USA (2016) 113(41):E6055-E6063. [Pubmed]
- Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1
- Kitago Y, Kaneko MK, Ogasawara S, Kato Y, and Takagi J.
Biochem Biophys Res Commun. (2016) 478(3):1274-9. [Pubmed]
- Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin
- Ozawa A, Sato Y, Imabayashi T, Uemura T, Takagi J, and Sekiguchi K.
J Biol Chem. (2016) 291(22):11551-65. [Pubmed]
- Structure of the plexin ectodomain bound by semaphorin-mimicking antibodies
- Suzuki K, Tsunoda H, Omiya R, Matoba K, Baba T, Suzuki S, Segawa H, Kumanogoh A, Iwasaki K, Hattori K, Takagi J.
PLoS One (2016) 11 (6):e0156719. [Pubmed]
- Tailored placement of a turn-forming PA tag into the structured domain of a protein to probe its conformational state
- Fujii Y, Matsunaga Y, Arimori T, Kitago Y, Ogasawara S, Kaneko M, Kato Y, and Takagi J.
J. Cell Science (2016) 129:1512-1522. [Pubmed]
- Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin
- Mihara E, Hirai H, Yamamoto H, Tamura-Kawakami K, Matano M, Kikuchi A, Sato T, and Takagi J.
eLife (2016) 5:e11621. [Pubmed]
- Structural and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
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