2025
- 2025.04.02News
Ikumi Kurita joined our lab. She will take part in the joint project with Matrixome, Inc., on the evaluation of laminin-511 E8 fragment-coated microspheres as culture substrates for expansion of human iPS cells. Welcome Ikumi!
2024
- 2025.01.29News
Yukimasa Taniguchi presented our recent progress on laminin-functionalized fibrin gels at the first Multimodal ECM Fusion Workshop entitled “Designer Matrix and Organoid” to be held in Kobe on January 29, 2025.
- 2024.11.08News
Kiyotoshi Sekiguchi overviewed the mechanistic basis for laminin-integrin interactions at the symposium "Revitalization of extracellular matrix research: molecular entities of the extracellular environment that govern cell fate and behavior" organized by the 97th annual meeting of the Japanese Biochemical Society to be held in Yokohama.
- 2024.09.26News
Kiyotoshi Sekiguchi presented a web seminar titled 'Why Cells Need Their Adhesive Substrates?' for the members of the Multimordal ECM Project, part of the MEXT KAKENHI Transformative Research Area (A).
- 2024.07.20News
Kiyotoshi Sekiguchi delivered a lecture titled 'Why Cells Need Their Adhesive Substrates?' at the opening ceremony of Jikei Nakanoshima Center, Jikei University of Health Care Sciences, held at Nakanoshima Qross, Osaka, on July 20.
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- 2024.07.30News
We had a get-together to welcome two groups led by Madoka Suzuki and Satoshi Toda, both established in IPR's Joint Research Building this April.
- 2024.07.22News
Kakeru Sugiyama joined our lab. He will take part in the joint project with Matrixome, Inc., on the evaluation of laminin-511 E8 fragment-coated microspheres as culture substrates for expansion of human iPS cells. Welcome Kakeru!
- 2024.06.17Press Release
A collaborative work with Takafumi Hasegawa of Tohoku University has been published online in Cell Death Discovery. This paper reports the evidence for the involvement of RME-8/DNAJC13, a protein involved in endosomal transport and originally found in our lab, in pathogenesis of Parkinson's disease.
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Click here for the publication site of Cell Death Discovery.
- 2024.06.13News
Professor Yoshihiro Ishikawa visited our lab and gave a lecture on "Structure, function, and biosynthesis of type IV collagens". Thank you, Yoshi, for very inspiring talk!
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- 2024.05.30Press Release
A collaborative work with Prof. Hironobu Hojo of our Institute has been published online in Frontiers in Chemistry. This paper reports the synthesis and characterization of the cyclic RGD-containing peptides derivatized from cysteinyl RGD-peptidyl cysteinyl prolyl esters by the native chemical ligation method.
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Click here for the publication site of Frontiers in Chemistry.
- 2024.05.28News
The paper reporting the enhanced myogenic induction from human iPS cells on heparan sulfate chain-attached laminin 421 E8 fragment was featured in the online edition of Nikkei Newspaper.
- 2024.04.29Press Release
A paper reporting the enhanced myogenic induction from human iPS cells on heparan sulfate chain-attached laminin 421 E8 fragment, the achievement of the collaborative work with Prof. Hidetoshi Sakurai of Center for iPS Cell Research and Application, Kyoto University, has been published in Advanced Science online.
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Click here for the publication site of Advanced Science.
- 2024.04.26News
Fumi Ebisu, a senior researcher who has been in charge of our human iPSCs group, retired from our team on April 30. Thank you, Fumi, for your dedication and many contributions to our team!
- 2024.04.11Award
Kiyotoshi Sekiguchi gave a keynote lecture titled "Mechanistic Basis for Laminin-Integrin Interaction" at ASMB (American Society for Matrix Biology) Basement Membrane Workshop held at Wellcome Centre for Cell-Matrix Research, University of Manchester, on April 11.
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- 2024.04.02News
We held a cherry blossom viewing event for the first time in a while.
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- 2024.04.02News
Haruka Kawaguchi joined our lab. She will take part in the joint project with Matrixome, Inc., on the evaluation of laminin-511 E8 fragment-coated microspheres as culture substrates for expansion of human iPS cells. Welcome Haruka!
- 2024.03.26Award
Yukimasa Taniguchi received "Excellent Presentation Award" at 23rd Annual Meeting of the Japanese Society for Regenerative Medicine.
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- 2024.03.21-22News
Yukimasa Taniguchi and Kohei Minobe presented their results at the 23rd Annual Meeting of the Japanese Society for Regenerative Medicine to be held in Niigata from March 21-23, 2024.
- 2024.03.16News
Shaoliang Li, an alumnus of our lab, has returned and takes part in our project on fabrication of chemically defined basement membrane-like gels. Welcome Shaoliang!
- 2024.03.15News
Ko Tsutsui, an alumnus of our laboratory and currently at University of Manchester, presented the results of our collaboration at the 7th International Workshop on Alport Syndrome to be held in Cyprus from March 14-16, 2024.
- 2023.12.26News
A farewell party was held for Ryoko Sato-Nishiuchi.
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- 2023.12.25Press Release
A collaborative work with Masato Nakagawa of CiRA, Kyoto University, has been published in Regenerative Therapy. This paper addresses the dual binding specificity of bFGF towards bFGFR and integrin alpha6beta1 in pluripotency of iPS cells.
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Click here for the publication site of Regenerative Therapy
- 2023.12.15News
Sekiguchi Laboratory's year-end party was held for the first time in five years.
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- 2023.11.25News
- Kiyotoshi Sekiguchi gave a Keynote Plenary Lecture at the 7th Annual Symposium of the Consortium for Advancement of Stem Cell Manipulation on November 25, 2023.
- 2023.11.22News
Kiyotoshi Sekiguchi was awarded a plaque of the certificate of Distinguished Professorship from the President of Osaka University.
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- 2023.11.21News
- Yukimasa Taniguchi presented our recent progress on the development of the fibrin gel functionalized with the laminin-511 E8 fragment at IPR Retreat 2023.
- 2023.11.18Press Release
A collaborative work on live imaging of human eccrine sweat glands with Kie Nakashima, Hiroko Kato, Fumitaka Fujita, and other members of Laboratory of Advanced Cosmetic Science, Graduate School of pharmaceutical Sciences, Osaka University, Fumihiro Okada of Mandom Corporation, Hiroyuki Murota (currently Nagasaki University), Yukinobu Nakagawa, Atsushi Tanemura, and Ichiro Katayama of Graduate School of Medicine, Osaka University was published in Communications Biology. This is the first paper that reports the dynamic contractile motions of isolated eccrine sweat glands that propel peristaltic transport of sweat.
The movie here
Click here for the publication site of Communications Biology
- 2023.10.06News
Group photos of Sekiguchi Lab for the past quarter century are uploaded as a YouTube movie.
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- 2023.09.09News
A celebration party for Kiyotoshi Sekiguchi’s Medal with Purple Ribbon was held at Centra Grand Hotel Osaka.
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Click here for details of the celebration party
- 2023.09.04Press Release
A paper coauthored with Yoriko Sugiyama-Nakagiri of Kao Corporation was published online in Scientific Reports. This paper reports that perlecan-conjugated laminin E8 fragments promote the differentiation of human iPS cells into skin-derived precursor cells that have the ability to differentiate into adipocytes, osteocytes, and Schwann cells.
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Click here for the publication site of pubmed website
- 2023.09.04Press Release
Ryoko Sato-Nishiuchi’s paper reporting the interaction of Polydom/SVEP1 with Tie1 was published in J Cell Biol.
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Click here for the publication site of Journal of Cell Biology
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2023
- 2023.04.29Award
Osaka University awarded the title of "Osaka University Distinguished Professor" to Kiyotoshi Sekiguchi.
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Click here for a list of Osaka University Distinguished Professors
- 2023.04.28Award
Kiyotoshi Sekiguchi was awarded the Medal with Purple Ribbon in the spring of 2023.
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Click here for photos at the award ceremony
- 2023.04.21Press Release
- Sugiko Futaki's paper reporting in vivo imaging of basement membranes using a nidogen-EGFP reporter mouse was published online in Matrix Biology Plus.
- 2023.03.23News
- Kohei Minobe presented his work at the annual meeting of Japanese Society for Regenerative Medicine held in Kyoto.
- 2023.03.15News
- Our website has been renewed.
2022
- 2022.08.11Press Release
- Sugiko Futaki's paper reporting the live imaging of the basement membrane of mouse salivary glands was published in Microscopy.
This work was conducted in collaboration with Yuichi Kadoya of Kitasato University.
- 2022.08.01News
- Publications page has been updated.
- 2022.07.22Press Release
- First paper reporting the perlecan-conjugated laminin E8 fragments was published in Stem Cells Translational Medicine.
Our collaborative work with Jun Takahashi at CiRA, Kyoto University demonstrates that the perlecan-conjugated laminin-511/521 E8 fragments enhance maturation of hiPSC-derived dopaminergic progenitors grafted to Parkinson's disease model.
- 2022.01.07Press Release
- A paper reporting immortalized myoepithelial cells of human eccrine sweat glands was published in Scientific Reports.
This work was conducted in collaboration with Mandom, Inc.
2021
- 2021.10.15Press Release
- A paper reporting LAMA5 gene biallelic variants in steroid-resistant nephrotic syndrome patients was published in Kidney360.
This work was conducted in collaboration with Kandai Nozu of Kobe University.
- 2021.06.29Press Release
- A paper reporting the structure of a complex between laminin511E8 and integrin alpha6beta1 as revealed by cryo-electron microscopy was published in Nature Communications.
The work was conducted in collaboration with Junichi Takagi and Takao Arimori of our Institute.